Abstract
Breast cancer and melanoma are among the most common conditions treated by surgeons. For both disorders, surgeons must be familiar with the diagnosis, evaluation, and treatment of related benign conditions and with all aspects of the multidisciplinary care of these cancers. This is critical so that surgeons who are often the initial provider for these cancers appropriately integrate surgery with all aspects of care including adjuvant systemic and radiation therapy. For breast cancer, needle biopsy is the proper initial biopsy in virtually all cases. For both ductal carcinoma in situ and invasive cancer, breast-conserving therapy (BCT) provides equivalent outcome to mastectomy and is the most common treatment. Radiation is required in most cases of BCT and in cases of large cancers and/or positive nodes with mastectomy. Recently reported clinical trials with sentinel node biopsy have refined lymph node surgery by eliminating the need for axillary dissection in women with negative nodes and many with positive nodes. For melanoma, critical issues include understanding the optimal margin width necessary for resection based on the characteristics of the primary lesion. In addition, a thorough understanding of the risk and therapeutic impact of lymph node metastasis is necessary to allow proper planning of lymph node surgery with SLNB and completion node dissection. This chapter addresses these and other key issues in surgical management of these diseases.
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References
Allegra CJ, Aberle DR, Ganschow P, et al. National institutes of health state-of-the-science conference statement: diagnosis and management of ductal carcinoma in situ September 22-24, 2009. J Natl Cancer Inst. 2010;102(3):161–9.
Andtbacka RH, Gershenwald JE. Role of sentinel lymph node biopsy in patients with thin melanoma. J Natl Compr Canc Netw. 2009;7(3):308–17.
Balch CM, Soong SJ, Smith T, et al. Long-term results of a prospective surgical trial comparing 2 cm vs. 4 cm excision margins for 740 patients with 1–4 mm melanomas. Ann Surg Oncol. 2001;8(2):101–8.
Balch CM, Gershenwald JE, Soong SJ, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 2009;27(36):6199–206.
Bear HD. Neoadjuvant chemotherapy for operable breast cancer: individualizing locoregional and systemic therapy. Surg Oncol Clin N Am. 2010;19(3):607–26.
Brachtel EF, Rusby JE, Michaelson JS, et al. Occult nipple involvement in breast cancer: clinicopathologic findings in 316 consecutive mastectomy specimens. J Clin Oncol. 2009;27(30):4948–54.
Chang YW, Kwon KH, Goo DE, et al. Sonographic differentiation of benign and malignant cystic lesions of the breast. J Ultrasound Med. 2007;26(1):47–53.
NCCN Clinical practice guidelines 2011 – melanoma. http://www.nccn.org/professionals/physician_gls/pdf/melanoma.pdf. Accessed 24 Oct 2011.
Cohn-Cedermark G, Rutqvist LE, Andersson R, et al. Long term results of a randomized study by the Swedish Melanoma Study Group on 2-cm versus 5-cm resection margins for patients with cutaneous melanoma with a tumor thickness of 0.8–2.0 mm. Cancer. 2000;89(7):1495–501.
Dixon JM, Khan LR. Treatment of breast infection. BMJ. 2011;342(11):d396.
Eberl MM, Fox CH, Edge SB, et al. BI-RADS classification for management of abnormal mammograms. J Am Board Fam Med. 2006;19(2):161–4.
Fisher B, Dignam J, Wolmark N, et al. Tamoxifen in treatment of intraductal breast cancer: national surgical adjuvant breast and bowel project B-24 randomised controlled trial. Lancet. 1999;353(9169):1993–2000.
Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233–41.
Giuliano AE, Kirgan DM, Guenther JM, Morton DL. Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg. 1994;220(3):391–8. discussion 398–401.
Giuliano AE, Hunt KK, Ballman KV, et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA. 2011;305(6):569–75.
Gnerlich J, Jeffe DB, Deshpande AD, et al. Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988–2003 SEER data. Ann Surg Oncol. 2007;14(8):2187–94.
Gollapalli V, Liao J, Dudakovic A, et al. Risk factors for development and recurrence of primary breast abscesses. J Am Coll Surg. 2010;211(1):41–8.
Karabakhtsian RG, Johnson R, Sumkin J, Dabbs DJ. The clinical significance of lobular neoplasia on breast core biopsy. Am J Surg Pathol. 2007;31(5):717–23.
Kaufmann M, Morrow M, von Minckwitz G, Harris JR, Biedenkipf Expert Panel Members. Locoregional treatment of primary breast cancer: consensus recommendations from an international expert panel. Cancer. 2010;116(5):1184–91.
Khayat D, Rixe O, Martin G, et al. Surgical margins in cutaneous melanoma (2 cm versus 5 cm for lesions measuring less than 2.1-mm thick). Cancer. 2003;97(8):1941–6.
Krag DN, Anderson SJ, Julian TB, et al. Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial. Lancet Oncol. 2007;8(10):881–8.
Li S, Grant CS, Degnim A, Donohue J. Surgical management of recurrent subareolar breast abscesses: mayo clinic experience. Am J Surg. 2006;192(4):528–9.
McMasters KM, Reintgen DS, Ross MI, et al. Sentinel lymph node biopsy for melanoma: controversy despite widespread agreement. J Clin Oncol. 2001;19(11):2851–5.
Morton DL, Wen DR, Wong JH, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg. 1992;127(4):392–9.
Morton DL, Thompson JF, Essner R, et al. Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: a multicenter trial. Multicenter Selective Lymphadenectomy Trial Group. Ann Surg. 1999;230(4):453–63. discussion 463–455.
Morton DL, Cochran AJ, Thompson JF, et al. Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-I, an international multicenter trial. Ann Surg. 2005;242(3):302–11. discussion 311–303.
Morton DL, Thompson JF, Cochran AJ, et al. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med. 2006;355(13):1307–17.
National Cancer Institute. http://www.cancer.gov/cancertopics/types/melanoma. Accessed 24 Oct 2011.
Neuman HB, Morrogh M, Gonen M, et al. Stage IV breast cancer in the era of targeted therapy: does surgery of the primary tumor matter? Cancer. 2010;116(5):1226–33.
Pandit-Taskar N, Dauer LT, Montgomery L, et al. Organ and fetal absorbed dose estimates from 99mTc-sulfur colloid lymphoscintigraphy and sentinel node localization in breast cancer patients. J Nucl Med. 2006;47(7):1202–8.
Rashaan ZM, Bastiaannet E, Portielje JE, et al. Surgery in metastatic breast cancer: patients with a favorable profile seem to have the most benefit from surgery. Eur J Surg Oncol. 2012;38(1):52–6.
Saslow D, Boetes C, Burke W, et al. American cancer society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin. 2007;57(2):75–89.
SEER Cancer Statistics Review. http://seer.cancer.gov/csr/1975_2007/. Accessed 24 Oct 2011.
Smith RA, Cokkinides V, Brooks D, et al. Cancer screening in the United States, 2011: a review of current American cancer society guidelines and issues in cancer screening. CA Cancer J Clin. 2011;61(1):8–30.
Spillane AJ, Cheung BL, Stretch JR, et al. Proposed quality standards for regional lymph node dissections in patients with melanoma. Ann Surg. 2009;249(3):473–80.
Thomas JM, Newton-Bishop J, A’Hern R, et al. Excision margins in high-risk malignant melanoma. N Engl J Med. 2004;350(8):757–66.
Thompson JF, Kam PC, Waugh RC, Harman CR. Isolated limb infusion with cytotoxic agents: a simple alternative to isolated limb perfusion. Semin Surg Oncol. 1998;14(3):238–47.
Veronesi U, Cascinelli N, Adamus J, et al. Thin stage I primary cutaneous malignant melanoma. Comparison of excision with margins of 1 or 3 cm. N Engl J Med. 1988;318(18):1159–62.
Weaver DL, Ashikaga T, Krag DN, et al. Effect of occult metastases on survival in node-negative breast cancer. N Engl J Med. 2011;364(5):412–21.
Wrightson WR, Wong SL, Edwards MJ, et al. Complications associated with sentinel lymph node biopsy for melanoma. Ann Surg Oncol. 2003;10(6):676–80.
Acknowledgement
The chapter on Concepts in Breast Surgery was contributed by Alison Estabrook, MD, in the previous edition.
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Gutierrez, L.A., Sanghera, S.S., Skitzki, J.J., Edge, S.B. (2014). Concepts in Breast and Melanoma Surgery. In: Scott-Conner, C. (eds) Chassin's Operative Strategy in General Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1393-6_109
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DOI: https://doi.org/10.1007/978-1-4614-1393-6_109
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