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Atherosclerosis, Caveolae and Caveolin-1

  • Stephanos Pavlides
  • Jorge L. Gutierrez-Pajares
  • Christiane Danilo
  • Michael P. Lisanti
  • Philippe G. Frank
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 729)

Abstract

Atherosclerosis is a disease of the blood vessel characterized by the development of an arterial occlusion containing lipid and cellular deposits. Caveolae are 50–100 nm cell surface plasma membrane invaginations that are believed to play an important role in the regulation of cellular signaling and transport of molecules among others. These organelles are enriched in sphingolipids and cholesterol and are characterized by the presence of the protein caveolin-1. Caveolin-1 and caveolae are present in most of the cells involved in the development of atherosclerosis. The current literature suggests a rather complex role for caveolin-1 in this disease, with evidence of either pro- or anti-atherogenic functions depending on the cell type examined. In the present chapter, the various roles of caveolae and caveolin-1 in the development of atherosclerosis are examined.

Keywords

Atherosclerosis Development Striate Muscle Cell Smooth Muscle Cell Migration Macrophage Apoptosis Vascular Smooth Muscle Cell Migration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  • Stephanos Pavlides
    • 1
  • Jorge L. Gutierrez-Pajares
    • 1
  • Christiane Danilo
    • 1
  • Michael P. Lisanti
    • 1
  • Philippe G. Frank
    • 1
  1. 1.Departments of Cancer Biology and Stem Cell Biology and Regenerative MedicineThomas Jefferson UniversityPhiladelphiaUSA

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