Caveolae and the Regulation of Endocytosis

  • Anna L. Kiss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 729)

Abstract

Although clathrin-mediated endocytosis constitutes the main pathway for internalization of extracellular ligands and plasma membrane components it has generally been accepted that other uptake mechanisms—caveolae-mediated and noncaveolar raft-dependent endocytosis—also exist. During the last 20 years many papers have been published about caveolar endocytosis. These studies have fundamentally changed our view about the endocytotic role of caveolae. Views that caveolae are permanently static structures1 have been extensively considered and rejected. Although the initial steps leading to the pinching off of caveolae from the plasma membrane have been studied in details, there are still contradictory data about the intracellular trafficking of caveolae. It is still not entirely clear whether caveolar endocytosis represents an uptake pathway with distinct cellular compartments to avoid lysosomal degradation or ligands taken up by caveolae can also be targeted to late endosomes/lysosomes.

In this chapter, we summarize the data available about caveolar endocytosis focusing on the intracellular route of caveolae and we provide data supporting that caveolar endocytosis can join the classical endocytotic pathway.

Keywords

Tyrosine Serine Ceramide Cholera Adapter 

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  • Anna L. Kiss
    • 1
  1. 1.Department of Human Morphology and Developmental BiologySemmelweis UniversityBudapestHungary

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