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Antiphospholipid Syndrome

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Lupus Erythematosus

Abstract

The antiphospholipid syndrome (APS) is a disorder that is characterized by the presence of antibodies directed against phospholipid moieties in conjunction with venous and/or arterial thromboembolic events and/or obstetrical complications. There are other associated features including but not limited to seizures, thrombocytopenia and autoimmune hemolytic anemia, livedo reticularis, and renal disease. Rare complications include the catastrophic APS in which multiple clotting events occur simultaneously or in rapid succession. The antiphospholipid antibody syndrome can be seen by itself; primary APS, or in conjunction with other diseases such as systemic lupus erythematosus (SLE); secondary APS. This chapter will discuss the clinical manifestations and the management of the APS.

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Author information

Authors and Affiliations

  1. Division of Rheumatology, Lupus and Antiphospholipid Center, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Bonnie L. Bermas M.D. (Director)

  2. Harvard Medical School, Boston, MA, USA

    Bonnie L. Bermas M.D. (Director)

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  1. Bonnie L. Bermas M.D.
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Correspondence to Bonnie L. Bermas M.D. .

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Editors and Affiliations

  1. Brigham and Women's Hospital, Harvard Medical School, Div. of Rheumatology/Immunology/Allergy, Francis Street 75, Boston, 02115, USA

    Peter H. Schur

  2. Div. of Rheumatology/Immunology/Allergy, Brigham and Women's Hospital, Lupus Center, Francis Street 75, Boston, 02115, Massachusetts, USA

    Elena M. Massarotti

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Bermas, B.L. (2012). Antiphospholipid Syndrome. In: Schur, P., Massarotti, E. (eds) Lupus Erythematosus. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1189-5_15

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  • DOI: https://doi.org/10.1007/978-1-4614-1189-5_15

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-1188-8

  • Online ISBN: 978-1-4614-1189-5

  • eBook Packages: MedicineMedicine (R0)

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