Solid-State Techniques for Improving Solubility

Chapter
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 3)

Abstract

Poor aqueous solubility of a drug substance can often be attributed to strong intermolecular forces within its crystal lattice which, in turn, prevent molecules from escaping in solution. Through the use of solid-state chemistry, it is possible to modify the crystal structure in such a way that mitigates intermolecular forces, thus improving aqueous solubility and increasing rates of dissolution. Solid-state techniques utilized for solubility enhancement include the formation of salts, polymorphic or amorphous forms, and co-crystals. Each technique has specific advantages and, in some cases, disadvantages that may prevent its successful use. The purpose of this chapter is to describe each of the methods, allowing the reader to gain an understanding of solid-state modifications available for solubility enhancement.

Keywords

Entropy Crystallization Recrystallization Indomethacin Carbamazepine 

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Copyright information

© American Association of Pharmaceutical Scientists 2012

Authors and Affiliations

  1. 1.Division of Pharmaceutics, College of PharmacyThe University of Texas at AustinAustinUSA

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