Aminoglycosides are derivatives of naturally occurring organisms and several aminoglycosides have been introduced for clinical use since the discovery of streptomycin in 1947. Amikacin, gentamicin, kanamycin, netilmicin, neomycin, streptomycin, paromomycin, and tobramycin are currently approved by the FDA for use in the United States. Among these, amikacin, gentamicin, and tobramycin are most frequently used. Because of the availability of less toxic agents, aminoglycosides have been used less often in recent years (Fig. 9.1).


Ideal Body Weight Single Daily Dose Burkholderia Cepacia Complicated Urinary Tract Infection Estimate Creatinine Clearance 
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Further Reading

  1. Nicolau, D., Quintiliani, R., & Nightingale, C. H. (1992). Once-daily aminoglycosides. Conn Med, 56(10), 561–563.PubMedGoogle Scholar
  2. Nicolau, D. P., Freeman, C. D., Belliveau, P. P., Nightingale, C. H., Ross, J. W., & Quintiliani, R. (1995). Experience with a once-daily aminoglycoside program administered to 2,184 adult patients. Antimicrob Agents Chemother, 39(3), 650–655.PubMedCrossRefGoogle Scholar
  3. Siber, G. R., Echeverria, P., Smith, A. L., Paisley, J. W., & Smith, D. H. (1975). Pharmacokinetics of gentamicin in children and adults. J Infect Dis, 132(6), 637–651.PubMedCrossRefGoogle Scholar
  4. Zaske, D. E., Cipolle, R. J., Rotschafer, J. C., Solem, L. D., Mosier, N. R., & Strate, R. G. (1982). Gentamicin pharmacokinetics in 1,640 patients: method for control of serum concentrations. Antimicrob Agents Chemother, 21(3), 407–411.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of MedicineUniversity of Massachusetts Medical SchoolWorcesterUSA
  2. 2.UMass Memorial Health Care Clinical Professor of MedicineUniversity of Massachusetts Medical SchoolWorcesterUSA

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