Biomedical and Biochemical Effects
Potential toxic foreign compounds or metabolites are capable of interacting with an endogenous target, triggering perturbation in cellular functions, and mediating a biochemical or biomedical effect. The cells initially respond to such perturbation with repair and adaptive mechanisms. When the induced perturbation exceeds the repair and adaptive capacity, toxic effects occur. In most cases, foreign compounds are absorbed and distributed to target organs, where they exert harmful effects. Liver and kidneys are frequent target organs of toxicity. The exhibition of foreign compound toxicity including biomedical and biochemical effects may occur under the following circumstances.
KeywordsReactive Oxygen Species Cardiac Muscle Cell Nickel Compound CYP450 Isozyme Oxidative Protein Damage
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