Abstract
Some foreign compounds are acutely or potentially toxic, and others initially exhibit no intrinsic toxicity, but become harmful after metabolic conversion. Although foreign compound-metabolizing enzymes aim to produce water soluble metabolites, facilitating the excretion of foreign compounds from the body, however in many cases, metabolic conversion produces reactive intermediates. As a result of this, many toxic effects of foreign compounds do not result from the parent compounds, instead from reactive intermediates or metabolites that are formed inside cells.
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Chen, CH. (2012). Reactive Intermediate Formation. In: Activation and Detoxification Enzymes. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1049-2_6
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DOI: https://doi.org/10.1007/978-1-4614-1049-2_6
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