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Tissue Colonization in Biomaterial-Associated Infection

  • Sebastian A. J. ZaatEmail author
Chapter

Abstract

Biomedical devices made of biomaterials predispose to infection as they provide surfaces for biofilm formation by microorganisms. Moreover, their presence in host tissue also compromises the local host immune response, allowing bacteria to persist in the vicinity of medical devices to cause infection. Biofilm formation, particularly by staphylococci, has been described in depth in  Chaps. 2 and  Chaps. 6. This chapter therefore focuses on the colonization of peri-biomaterial tissue and host cells by bacteria, particularly staphylococci, on the characteristics of staphylococci residing intracellularly, the efficacy of antibiotics against intracellular staphylococci, and the pathogenic process leading to peri-implant tissue ­colonization and how immune modulation can contribute to prevent this.

Keywords

Colony Form Unit Intracellular Activity Intracellular Survival Foreign Body Response Small Colony Variant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The research on biomaterial-associated infection at our Department builds on the work of Professor Jacob Dankert, who passed away much too early. Much of our own research described in this chapter has been performed by Corine Broekhuizen and Jaap Jan Boelens during their PhD periods, with excellent support of Leonie de Boer, Kim Schipper, Jean Luc Murk, and Jan Meeldijk.

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA)University of AmsterdamAmsterdamThe Netherlands

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