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Selenium pp 531–544Cite as

Selenium and Adverse Health Conditions of Human Pregnancy

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Abstract

There is evidence that selenium affects a number of adverse pregnancy health conditions. While higher selenium status has been associated with a lower risk of miscarriage and preterm birth, the level of evidence is stronger for a benefit of higher selenium intake/status in preeclampsia and autoimmune thyroid disease characterized by raised thyroid peroxidase antibodies. The ability of selenium to reduce oxidative stress, endoplasmic reticulum stress, and inflammation, to protect the endothelium, to control eicosanoid production, to regulate vascular tone, and to reduce infection is likely to be important in the context of these conditions.

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Acknowledgements

I gratefully acknowledge helpful collaborations with Prof. Victor Pop and Prof. Chris Redman and financial support from the Wellcome Trust, the Waterloo Foundation, Pharma Nord, and Wassen International.

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Authors and Affiliations

  1. University of Surrey, Guildford, GU2 7XH, UK

    Margaret P. Rayman

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  1. Margaret P. Rayman
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Correspondence to Margaret P. Rayman .

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Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

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Rayman, M.P. (2011). Selenium and Adverse Health Conditions of Human Pregnancy. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_42

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