Skip to main content
SpringerLink
Log in

Functional Aspects of the Genomics of Selenoproteins and Selenocysteine Incorporation Machinery

  • Chapter
  • First Online:
Selenium

Abstract

Functional genetic variants have been identified in selenoprotein and related genes. These include mutations in the selenoprotein N and SECIS-binding protein 2 genes as well as single nucleotide polymorphisms in genes encoding selenoproteins P and S, selenoprotein 15 and glutathione peroxidases 1, 3, and 4. Disease-association studies suggest that genotype for these SNPs may affect risk for several disorders. There is evidence for epigenetic regulation of selenoprotein expression and regulation of epigenetic mechanisms by Se supply. DNA microarray studies have identified both selenoproteins and downstream pathways that are sensitive to Se intake. Genomics (transcriptomics, proteomics, data mining and genetics) is providing useful approaches for exploring the roles of selenoproteins in cell function and human health with an integrated perspective.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Allamand V, Richard P, Lescure A et al (2006) EMBO Rep 7:450

    PubMed  CAS  Google Scholar 

  2. Maiti B, Arbogast S, Allamand V et al (2009) Hum Mutat 30:411

    Article  PubMed  CAS  Google Scholar 

  3. Schoenmakers E, Agostini M, Mitchell C et al (2010) J Clin Invest 120:4220

    Article  PubMed  CAS  Google Scholar 

  4. Schomburg L, Dumitrescu AM, Liao XH et al (2009) Thyroid 19:277

    Article  PubMed  CAS  Google Scholar 

  5. Burk RF, Hill KE (2009) Biochim Biophys Acta 1790:1441

    Article  PubMed  CAS  Google Scholar 

  6. Al-Taie OH, Seufert J, Mork H et al (2002) Eur J Hum Genet 10:499

    Article  PubMed  CAS  Google Scholar 

  7. Méplan C, Crosley LK, Nicol F et al (2007) FASEB J 21:3063

    Article  PubMed  CAS  Google Scholar 

  8. Méplan C, Nicol F, Burtle BT et al (2009) Antioxid Redox Signal 11:2631

    Article  PubMed  CAS  Google Scholar 

  9. Forsberg L, de Faire U, Marklund SL et al (2000) Blood Cells Mol Dis 26:423

    Article  PubMed  CAS  Google Scholar 

  10. Jablonska E, Gromadzinska J, Reszka E et al (2009) Eur J Nutr 48:383

    Article  PubMed  CAS  Google Scholar 

  11. Bermano G, Pagmantidis V, Holloway N et al (2007) Genes Nutr 2:225

    Article  PubMed  CAS  Google Scholar 

  12. Méplan C, Crosley LK, Nicol F et al (2008) Am J Clin Nutr 87:1019

    PubMed  CAS  Google Scholar 

  13. Voetsch B, Jin RC, Bierl C et al (2007) Stroke 38:41

    Article  PubMed  CAS  Google Scholar 

  14. Hu YJ, Korotkov KV, Mehta R et al (2001) Cancer Res 61:2307

    PubMed  CAS  Google Scholar 

  15. Curran JE, Jowett JB, Elliott KS et al (2005) Nat Genet 37:1234

    Article  PubMed  CAS  Google Scholar 

  16. Cox DG, Hankinson SE, Kraft P et al (2004) Cancer Epidemiol Biomarkers Prev 13:1821

    PubMed  CAS  Google Scholar 

  17. Cox DG, Tamimi RM, Hunter DJ (2006) BMC Cancer 6:217

    Article  PubMed  Google Scholar 

  18. Hu YJ, Diamond AM (2003) Cancer Res 63:3347

    PubMed  CAS  Google Scholar 

  19. Ichimura Y, Habuchi T, Tsuchiya N et al (2004) J Urol 172:728

    Article  PubMed  CAS  Google Scholar 

  20. Ratnasinghe D, Tangrea JA, Andersen MR et al (2000) Cancer Res 60:6381

    PubMed  CAS  Google Scholar 

  21. Ravn-Haren G, Olsen A, Tjonneland A et al (2006) Carcinogenesis 27:820

    Article  PubMed  CAS  Google Scholar 

  22. Steinbrecher A, Méplan C, Hesketh JE et al (2010) Cancer Epidemiol Biomarkers Prev 19:2958

    Article  PubMed  CAS  Google Scholar 

  23. Cooper ML, Adami HO, Gronberg H et al (2008) Cancer Res 68:10171

    Article  PubMed  CAS  Google Scholar 

  24. Méplan C, Hughes DJ, Pardini B et al (2010) Carcinogenesis 31:1074

    Article  PubMed  CAS  Google Scholar 

  25. Sutherland A, Kim DH, Relton C et al (2010) Genes Nutr 5:215

    Article  PubMed  CAS  Google Scholar 

  26. Udler M, Maia AT, Cebrian A et al (2007) J Clin Oncol 25:3015

    Article  PubMed  CAS  Google Scholar 

  27. Penney KL, Schumacher FR, Li H et al (2010) Cancer Prevent Res 3:604

    Article  CAS  Google Scholar 

  28. Shibata T, Arisawa T, Tahara T et al (2009) BMC Gastroenterol 9:2

    Article  PubMed  Google Scholar 

  29. Jaenisch R, Bird A (2003) Nat Genet 33(Suppl):245

    Article  PubMed  CAS  Google Scholar 

  30. Ballestar E, Esteller M (2008) Adv Genet 61:247

    Article  PubMed  Google Scholar 

  31. Esteller M (2008) N Engl J Med 358:1148

    Article  PubMed  CAS  Google Scholar 

  32. Feinberg AP, Ohlsson R, Henikoff S (2006) Nat Rev Genet 7:21

    Article  PubMed  CAS  Google Scholar 

  33. Lodygin D, Epanchintsev A, Menssen A et al (2005) Cancer Res 65:4218

    Article  PubMed  CAS  Google Scholar 

  34. Yu YP, Paranjpe S, Nelson J et al (2005) Carcinogenesis 26:471

    Article  PubMed  CAS  Google Scholar 

  35. Yu YP, Yu G, Tseng G et al (2007) Cancer Res 67:8043

    Article  PubMed  CAS  Google Scholar 

  36. He Y, Wang Y, Li P et al (2011) Dig Dis Sci 56:681–688

    Article  PubMed  CAS  Google Scholar 

  37. Lee OJ, Schneider-Stock R, McChesney PA et al (2005) Neoplasia 7:854

    Article  PubMed  CAS  Google Scholar 

  38. De Luca A, Sacchetta P, Nieddu M et al (2007) BMC Mol Biol 8:39

    Article  PubMed  Google Scholar 

  39. Fomenko DE, Novoselov SV, Natarajan SK et al (2009) J Biol Chem 284:5986

    Article  PubMed  CAS  Google Scholar 

  40. Novoselov SV, Kim HY, Hua D et al (2010) Antioxid Redox Signal 12:829

    Article  PubMed  CAS  Google Scholar 

  41. Davis CD, Uthus EO (2003) J Nutr 133:2907

    PubMed  CAS  Google Scholar 

  42. Connelly-Frost A, Poole C, Satia JA et al (2009) Nutr Cancer 61:165

    Article  PubMed  CAS  Google Scholar 

  43. Hoffmann PR, Hoge SC, Li PA et al (2007) Nucleic Acids Res 35:3963

    Article  PubMed  CAS  Google Scholar 

  44. Kipp A, Banning A, van Schothorst EM et al (2009) Mol Nutr Food Res 53:1561

    Article  PubMed  CAS  Google Scholar 

  45. Pagmantidis V, Méplan C, van Schothorst EM et al (2008) Am J Clin Nutr 87:181

    PubMed  CAS  Google Scholar 

  46. Dong Y, Ganther HE, Stewart C et al (2002) Cancer Res 62:708

    PubMed  CAS  Google Scholar 

  47. Dong Y, Zhang H, Hawthorn L et al (2003) Cancer Res 63:52

    PubMed  CAS  Google Scholar 

  48. Zhao H, Whitfield ML, Xu T et al (2004) Mol Biol Cell 15:506

    Article  PubMed  CAS  Google Scholar 

  49. Müller M, Banning A, Brigelius-Flohé R et al (2010) Genes Nutr 5:297

    Article  PubMed  Google Scholar 

  50. Zhang H, Dong Y, Zhao H et al (2005) Cancer Genomics Proteomics 2:97

    PubMed  CAS  Google Scholar 

  51. Zhang J, Wang L, Anderson LB et al (2010) Cancer Prevent Res 3:994

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Work in JEH’s laboratory has been supported by BBSRC, Wellcome Trust, NuGO, Food Standards Agency and Newcastle Healthcare Charity.

Author information

Authors and Affiliations

  1. Institute for Cell and Molecular Biosciences and Human Nutrition Research Centre, The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK

    Catherine Méplan & John Hesketh

Authors
  1. Catherine Méplan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John Hesketh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to John Hesketh .

Editor information

Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Méplan, C., Hesketh, J. (2011). Functional Aspects of the Genomics of Selenoproteins and Selenocysteine Incorporation Machinery. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_40

Download citation

Publish with us

Policies and ethics

Search

Navigation