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Variations in Selenium Metabolism in Males and Females

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Abstract

Selenium elicits its effects on human health mainly in the form of selenoproteins, even though some selenocompound-specific effects have been described. The physiological roles of certain selenoproteins have been characterized in transgenic mice, and epidemiological analyses have indicated associations of selenoprotein genotypes with common pathologies. Supplementation studies yielded promising results indicating that selenium can reduce cancer risk, autoimmune disease, subfertility, or mortality risk in severe illness. General conclusions are drawn and discussed vividly in science, health politics, and elsewhere. But studies in experimental rodents indicate that selenium metabolism and selenoprotein expression patterns differ between the sexes. Similarly, the selenium-dependent reduction of cancer risk, subfertility, or mortality in sepsis is mainly observed in males but not in females. Selenium-dependent health effects in thyroiditis are described in females only, and associations of selenium status and goiter, thyroid nodules or cardiovascular disease are sexually dimorphic. Even the major side effect, i.e., increased diabetes risk, appears to be male-specific. Therefore, selenium metabolism and selenium health effects differ between females and males, and generalizations should not be made across the sexes.

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References

  1. Schmucker DL, Vesell ES (1993) Clin Pharmacol Ther 54:11

    Article  PubMed  CAS  Google Scholar 

  2. Hankins C (2008) Curr Opin HIV AIDS 3:514

    Article  PubMed  Google Scholar 

  3. Rademaker M (2001) Am J Clin Dermatol 2:349

    Article  PubMed  CAS  Google Scholar 

  4. Harris RZ, Benet LZ, Schwartz JB (1995) Drugs 50:222

    Article  PubMed  CAS  Google Scholar 

  5. Tanaka E (1999) J Clin Pharm Ther 24:339

    Article  PubMed  CAS  Google Scholar 

  6. Block G, Jensen CD, Norkus EP et al (2007) Nutr J 6:30

    Article  PubMed  Google Scholar 

  7. Rock CL (2007) Am J Clin Nutr 85:277S

    PubMed  CAS  Google Scholar 

  8. Klinge I (2008) Pharmacol Res 58:183

    Article  PubMed  Google Scholar 

  9. Bjelakovic G, Nikolova D, Gluud LL et al (2008) Cochrane Database Syst Rev:CD007176

    Google Scholar 

  10. Waters DJ, Chiang EC, Cooley DM et al (2004) Mutat Res 551:91

    Article  PubMed  CAS  Google Scholar 

  11. Schomburg L, Schweizer U (2009) Biochim Biophys Acta 1790:1453

    Article  PubMed  CAS  Google Scholar 

  12. Schwarz K, Foltz CM (1958) J Biol Chem 233:245

    PubMed  CAS  Google Scholar 

  13. McCoy KE, Weswig PH (1969) J Nutr 98:383

    PubMed  CAS  Google Scholar 

  14. Dickson RC, Tomlinson RH (1967) Clin Chim Acta 16:311

    Article  PubMed  CAS  Google Scholar 

  15. Brown DG, Burk RF (1973) J Nutr 103:102

    PubMed  CAS  Google Scholar 

  16. Kryukov GV, Castellano S, Novoselov SV et al (2003) Science 300:1439

    Article  PubMed  CAS  Google Scholar 

  17. Behne D, Weiler H, Kyriakopoulos A (1996) J Reprod Fertil106:291

    Article  PubMed  CAS  Google Scholar 

  18. Behne D, Hofer T, von Berswordt-Wallrabe R et al (1982) J Nutr 112:1682

    PubMed  CAS  Google Scholar 

  19. Flohé L (2007) Biol Chem 388:987

    Article  PubMed  Google Scholar 

  20. Olson GE, Winfrey VP, Hill KE et al (2008) J Biol Chem 283:6854

    Article  PubMed  CAS  Google Scholar 

  21. Chiu-Ugalde J, Theilig F, Behrends T et al (2010) Biochem J 431:103

    Article  PubMed  CAS  Google Scholar 

  22. Burk RF, Hill KE, Olson GE et al (2007) J Neurosci 27:6207

    Article  PubMed  CAS  Google Scholar 

  23. Olson GE, Winfrey VP, Nagdas SK et al (2007) J Biol Chem 282:12290

    Article  PubMed  CAS  Google Scholar 

  24. Olson GE, Winfrey VP, Nagdas SK et al (2005) Biol Reprod 73:201

    Article  PubMed  CAS  Google Scholar 

  25. Conrad M (2009) Biochim Biophys Acta 1790:1575

    Article  PubMed  CAS  Google Scholar 

  26. Schneider M, Forster H, Boersma A et al (2009) Faseb J 23:3233

    Article  PubMed  CAS  Google Scholar 

  27. Maiorino M, Bosello V, Ursini F et al (2003) Biol Reprod 68:1134

    Article  PubMed  CAS  Google Scholar 

  28. Kehr S, Malinouski M, Finney L et al (2009) J Mol Biol 389:808

    Article  PubMed  CAS  Google Scholar 

  29. Ursini F, Heim S, Kiess M et al (1999) Science 285:1393

    Article  PubMed  CAS  Google Scholar 

  30. Hawkes WC, Turek PJ (2001) J Androl 22:764

    PubMed  CAS  Google Scholar 

  31. Hatfield DL, Gladyshev VN (2002) Mol Cell Biol 22:3565

    Article  PubMed  CAS  Google Scholar 

  32. Pang ST, Dillner K, Wu X et al (2002) Endocrinology 143:4897

    Article  PubMed  CAS  Google Scholar 

  33. Riese C, Michaelis M, Mentrup B et al (2006) Endocrinology 147:5883

    Article  PubMed  CAS  Google Scholar 

  34. Roveri A, Casasco A, Maiorino M et al (1992) J Biol Chem 267:6142

    PubMed  CAS  Google Scholar 

  35. Maiorino M, Wissing JB, Brigelius-Flohe R et al (1998) Faseb J 12:1359

    PubMed  CAS  Google Scholar 

  36. Conrad M, Schneider M, Seiler A et al (2007) Biol Chem 388:1019

    Article  PubMed  CAS  Google Scholar 

  37. Ufer C, Borchert A, Kuhn H (2003) Nucleic Acids Res 31:4293

    Article  PubMed  CAS  Google Scholar 

  38. Ufer C, Wang CC, Fahling M et al (2008) Genes Dev 22:1838

    Article  PubMed  CAS  Google Scholar 

  39. Méplan C, Crosley LK, Nicol F et al (2008) Am J Clin Nutr 87:1019

    PubMed  CAS  Google Scholar 

  40. Hesketh J (2008) Annu Rev Nutr 28:157

    Article  PubMed  CAS  Google Scholar 

  41. Schomburg L, Riese C, Renko K et al (2007) Biol Chem 388:1035

    Article  PubMed  CAS  Google Scholar 

  42. Shamberger RJ, Willis CE (1971) CRC Crit Rev Clin Lab Sci 2:211

    Article  PubMed  CAS  Google Scholar 

  43. Combs GF Jr (2005) J Nutr 135:343

    PubMed  CAS  Google Scholar 

  44. Clark LC, Combs GF Jr, Turnbull BW et al (1996) Jama 276:1957

    Article  PubMed  CAS  Google Scholar 

  45. Duffield-Lillico AJ, Reid ME, Turnbull BW et al (2002) Cancer Epidemiol Biomarkers Prev 11:630

    PubMed  CAS  Google Scholar 

  46. Klein EA, Thompson IM, Lippman SM et al (2001) J Urol 166:1311

    Article  PubMed  CAS  Google Scholar 

  47. Galan P, Briancon S, Favier A et al (2005) Br J Nutr 94:125

    Article  PubMed  CAS  Google Scholar 

  48. Kok FJ, de Bruijn AM, Hofman A et al (1987) Am J Epidemiol 125:12

    PubMed  CAS  Google Scholar 

  49. Knekt P, Aromaa A, Maatela J et al (1990) J Natl Cancer Inst 82:864

    Article  PubMed  CAS  Google Scholar 

  50. Amaral AF, Cantor KP, Silverman DT et al (2010) Cancer Epidemiol Biomarkers Prev 19:2407

    Article  PubMed  CAS  Google Scholar 

  51. Michaud DS, De Vivo I, Morris JS et al (2005) Br J Cancer 93:804

    Article  PubMed  CAS  Google Scholar 

  52. Maehira F, Luyo GA, Miyagi I et al (2002) Clin Chim Acta 316:137

    Article  PubMed  CAS  Google Scholar 

  53. Hawker FH, Stewart PM, Snitch PJ (1990) Crit Care Med 18:442

    Article  PubMed  CAS  Google Scholar 

  54. Forceville X, Vitoux D, Gauzit R et al (1998) Crit Care Med 26:1536

    Article  PubMed  CAS  Google Scholar 

  55. Sakr Y, Reinhart K, Bloos F et al (2007) Br J Anaesth 98:775

    Article  PubMed  CAS  Google Scholar 

  56. Wang Z, Forceville X, Van Antwerpen P et al (2009) Shock 32:140

    Article  PubMed  CAS  Google Scholar 

  57. Schomburg L (2010) Shock 33:554

    PubMed  Google Scholar 

  58. Angstwurm MW, Engelmann L, Zimmermann T et al (2007) Crit Care Med35:118

    Article  PubMed  CAS  Google Scholar 

  59. Schomburg L (2007) Crit Care Med 35:995

    Article  PubMed  Google Scholar 

  60. Stoedter M, Renko K, Hog A et al (2010) Biochem J 429:43

    Article  PubMed  CAS  Google Scholar 

  61. Baum MK, Shor-Posner G, Lai S et al (1997) J Acquir Immune Defic Syndr Hum Retrovirol 15:370

    Article  PubMed  CAS  Google Scholar 

  62. Rousseau MC, Molines C, Moreau J et al (2000) Ann Nutr Metab 44:212

    Article  PubMed  CAS  Google Scholar 

  63. Feldkamp J (2009) Dtsch Med Wochenschr 134:2504

    Article  PubMed  CAS  Google Scholar 

  64. Erdal M, Sahin M, Hasimi A et al (2008) Biol Trace Elem Res 123:1

    Article  PubMed  CAS  Google Scholar 

  65. Schomburg L, Köhrle J (2008) Mol Nutr Food Res 52:1235

    Article  PubMed  CAS  Google Scholar 

  66. Toulis KA, Anastasilakis AD, Tzellos TG et al (2010) Thyroid 20:1163

    Article  PubMed  CAS  Google Scholar 

  67. Duntas LH, Mantzou E, Koutras DA (2003) Eur J Endocrinol 148:389

    Article  PubMed  CAS  Google Scholar 

  68. Derumeaux H, Valeix P, Castetbon K et al (2003) Eur J Endocrinol 148:309

    Article  PubMed  CAS  Google Scholar 

  69. Rasmussen L, Schomburg L, Kohrle J et al (2011) Eur J Endocrinol 164:585

    Google Scholar 

  70. Blankenberg S, Rupprecht HJ, Bickel C et al (2003) N Engl J Med 349:1605

    Article  PubMed  CAS  Google Scholar 

  71. Nawrot TS, Staessen JA, Roels HA et al (2007) Eur Heart J 28:628

    Article  PubMed  CAS  Google Scholar 

  72. Schomburg L (2007) Eur Heart J 28:2043

    Article  PubMed  Google Scholar 

  73. Navas-Acien A, Bleys J, Guallar E (2008) Curr Opin Lipidol 19:43

    Article  PubMed  CAS  Google Scholar 

  74. Blum A, Blum N (2009) Gend Med 6:410

    Article  PubMed  Google Scholar 

  75. Anand SS, Islam S, Rosengren A et al (2008) Eur Heart J 29:932

    Article  PubMed  Google Scholar 

  76. Flores-Mateo G, Navas-Acien A, Pastor-Barriuso R et al (2006) Am J Clin Nutr 84:762

    PubMed  CAS  Google Scholar 

  77. Lubos E, Sinning CR, Schnabel RB et al (2010) Atherosclerosis 209:271

    Article  PubMed  CAS  Google Scholar 

  78. Renko K, Hofmann PJ, Stoedter M et al (2009) Faseb J 23:1758

    Article  PubMed  CAS  Google Scholar 

  79. Sutter ME, Thomas JD, Brown J et al (2008) Ann Intern Med 148:970

    PubMed  Google Scholar 

  80. Stranges S, Marshall JR, Natarajan R et al (2007) Ann Intern Med 147:217

    PubMed  Google Scholar 

  81. Bleys J, Navas-Acien A, Guallar E (2007) Diabetes Care 30:829

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledegments

Work in the author’s lab is supported by the German Research Foundation (DFG; GraKo 1208, Scho 849/2-2) and German Cancer Aid (Deutsche Krebshilfe, 10–1792 Scho2).

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Authors and Affiliations

  1. Institute for Experimental Endocrinology, Südring 10 CVK, Charité-University Medicine Berlin, Berlin, 13353, Germany

    Lutz Schomburg

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  1. Lutz Schomburg
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Correspondence to Lutz Schomburg .

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Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

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Schomburg, L. (2011). Variations in Selenium Metabolism in Males and Females. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_33

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