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Selenium and Male Reproduction

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Selenium

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Abstract

Selenium (Se) has long been known to be important for male reproduction as severe Se deficiency causes impaired male fertility in livestock, laboratory animals, and humans. In the last decade, the role of Se in male reproduction was elucidated at the molecular level, establishing the roles of specific selenoproteins in this process. Using protein- and isoform-specific knockout mice, it was found that at least two selenoproteins are responsible for the effect of Se: Selenoprotein P, a protein secreted from the liver and serving as the main source of Se for testes, and a mitochondrial form of glutathione peroxidase 4 that has two functions: a peroxidase specific for phospholipid hydroperoxides and a structural component in the midpiece of sperm. Clinical studies further showed that the compromised glutathione peroxidase 4 function in testes is associated with male infertility. In addition, application of X-ray fluorescent microscopy allowed direct visualization of Se distribution in testis and sperm, defining the roles of individual selenoproteins during spermatogenesis. Finally, recent identification of individuals with SBP2 mutations characterized by impaired fertility and azoospermia provided further evidence for importance of Se and selenoproteins in male reproduction.

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Acknowledgement

This work was supported by National Institutes of Health grants (to VNG).

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Authors and Affiliations

  1. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Anton A. Turanov, Mikalai Malinouski & Vadim N. Gladyshev

Authors
  1. Anton A. Turanov
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  2. Mikalai Malinouski
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  3. Vadim N. Gladyshev
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Corresponding author

Correspondence to Vadim N. Gladyshev .

Editor information

Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

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Turanov, A.A., Malinouski, M., Gladyshev, V.N. (2011). Selenium and Male Reproduction. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_32

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