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Selenium pp 355–367Cite as

Schizophrenia, Oxidative Stress and Selenium

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Abstract

Schizophrenia is a complex, crippling mental illness that is influenced by multiple environmental and genetic factors. Oxidative stress is among the most prominent factors implicated in schizophrenia. Many components of the oxidative stress pathways influence cell-signaling cascades that regulate several neurotransmitter systems. One of the characteristic features of schizophrenia is altered dopaminergic, glutamatergic, and GABAergic neurotransmission, which is influenced by oxidative stress and exacerbated by certain drugs of abuse. Selenoproteins play critical roles in defense against oxidative stress and include glutathione peroxidases, thioredoxin reductases, and iodothyronine deiodinases. Based upon their integral function in protection against oxidative stress, impaired selenoprotein synthesis and function may contribute to the pathogenesis of schizophrenia.

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Acknowledgement

Supported by NIH funding to MJB.

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Authors and Affiliations

  1. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, 96813, USA

    Matthew W. Pitts, Arjun V. Raman & Marla J. Berry

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  1. Matthew W. Pitts
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  2. Arjun V. Raman
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  3. Marla J. Berry
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Correspondence to Matthew W. Pitts .

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Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

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Pitts, M.W., Raman, A.V., Berry, M.J. (2011). Schizophrenia, Oxidative Stress and Selenium. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_28

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