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An Emerging Picture of the Biological Roles of Selenoprotein K

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Abstract

Recent insight has been made regarding the biological role(s) for selenoprotein K (SelK) in humans and other organisms. Suggested functions for mammalian SelK include protection against oxidative stress in cardiomyocytes, regulation of endoplasmic reticulum (ER) stress in HepG2 cells, and facilitation of calcium flux in immune cells during receptor-mediated activation. The data supporting these functions as well as other aspects of SelK are summarized in this chapter.

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Author information

Authors and Affiliations

  1. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI, 96816, USA

    Peter R. Hoffmann

Authors
  1. Peter R. Hoffmann
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Correspondence to Peter R. Hoffmann .

Editor information

Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

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Hoffmann, P.R. (2011). An Emerging Picture of the Biological Roles of Selenoprotein K. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_26

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