Skip to main content
SpringerLink
Log in

Glutathione Peroxidase 1 and Diabetes

  • Chapter
  • First Online:
Selenium

Abstract

Discovery of development of type 2 diabetes-like phenotypes in glutathione peroxidase-1 (GPx1) overexpressing mice reveals a novel function of this “oldest” and most abundant selenoprotein in the body. The finding signifies an exciting progress in Se biology, and helps understand metabolic impacts of Se supplementation on human health. While its dual role in coping with reactive oxygen and nitrogen species has received broad recognition, unique functions and mechanisms of GPx1 in β cell physiology, insulin synthesis and secretion, and body glucose homeostasis are just being unveiled. By modulating intracellular redox status, the GPx1 overproduction or knockout is able to regulate functional expressions of key transcriptional factors or protein in pancreatic islet and insulin-responsive tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rotruck JT, Pope AL, Ganther HE et al (1973) Science 179:588

    Article  PubMed  CAS  Google Scholar 

  2. Flohe L, Gunzler WA, Schock HH (1973) FEBS Lett 32:132

    Article  PubMed  CAS  Google Scholar 

  3. Lei XG, Cheng WH (2005) J Nutr 135:2295

    PubMed  CAS  Google Scholar 

  4. Cheng WH, Ho YS, Valentine BA et al (1998) J Nutr 128:070

    Google Scholar 

  5. Fu Y, Cheng WH, Porres JM et al (1999) Free Radic Biol Med 27:605

    Article  PubMed  CAS  Google Scholar 

  6. Cheng WH, Valentine BA, Lei XG (1999) J Nutr 129:1951

    PubMed  CAS  Google Scholar 

  7. Cheng WH, Ho Y-S, Ross D et al (1997) J Nutr 127:675

    PubMed  CAS  Google Scholar 

  8. Fu Y, Sies H, Lei XG (2001) J Biol Chem 276:43004

    Article  PubMed  CAS  Google Scholar 

  9. Fu Y, Porres J, Lei XG (2001) Biochem J 359:687

    Article  PubMed  CAS  Google Scholar 

  10. Lei XG, Zhu JH, McClung JP et al (2006) Biochem J 399:455

    Article  PubMed  CAS  Google Scholar 

  11. Lei XG, Cheng WH, McClung JP (2007) Annu Rev Nutr 27:41

    Article  PubMed  CAS  Google Scholar 

  12. Asayama K, Kooy N, Burr I (1986) J Lab Clin Med 107:459

    PubMed  CAS  Google Scholar 

  13. Forgione MA, Cap A, Liao R et al (2002) Circulation 106:1154

    Article  PubMed  CAS  Google Scholar 

  14. Hu JY, Korotkov KV, Mehta R et al (2001) Cancer Res 61:2307

    PubMed  CAS  Google Scholar 

  15. Kuzuya M, Ando F, Iguchi A et al (2008) Am J Clin Nutr 87:1939

    PubMed  CAS  Google Scholar 

  16. Rosen PP, Nawroth P, King G et al (2001) Diabetes Metab Res Rev 17:189

    Article  PubMed  CAS  Google Scholar 

  17. Brownlee M, Cerami A, Vlassara H (1988) N Engl J Med 318:1315

    Article  PubMed  CAS  Google Scholar 

  18. Takasu N, Asawa T, Komiya I et al (1991) J Biol Chem 266:2112

    PubMed  CAS  Google Scholar 

  19. Lebovitz RM, Zhang H, Vogel H et al (1996) Proc Natl Acad Sci USA 93:9782

    Article  PubMed  CAS  Google Scholar 

  20. Chu FF, Esworthy RS, Doroshow JH et al (1992) Blood 79:3233

    PubMed  CAS  Google Scholar 

  21. Tomas E, Lin YS, Dagher Z et al (2002) Ann NY Acad Sci 967:43

    Article  PubMed  CAS  Google Scholar 

  22. Like A, Rossini A (1976) Science 193:415

    Article  PubMed  CAS  Google Scholar 

  23. Takasu N, Komiya I, Asawa T et al (1991) Diabetes 40:1141

    Article  PubMed  CAS  Google Scholar 

  24. Evans JL, Goldfine ID, Maddux BA et al (2002) Endocr Rev 23:599

    Article  PubMed  CAS  Google Scholar 

  25. Hansen LL, Ikeda Y, Olsen GS et al (1999) J Biol Chem 274:25078

    Article  PubMed  CAS  Google Scholar 

  26. Lei XG, Vatamaniuk MZ (2011) Antioxid Redox Signal 14:489

    Article  PubMed  CAS  Google Scholar 

  27. Tremblay F, Lavigne C, Jacques H et al (2001) Diabetes 50:1901

    Article  PubMed  CAS  Google Scholar 

  28. Mahadev K, Zilbering A, Zhu L et al (2001) J Biol Chem 276:21938

    Article  PubMed  CAS  Google Scholar 

  29. Esposito F, Chirico G, Gesualdi NM et al (2003) J Biol Chem 278:20828

    Article  PubMed  CAS  Google Scholar 

  30. Leloup C, Tourrel-Cuzin CC, Magnan C et al (2009) Diabetes 58:673

    Article  PubMed  CAS  Google Scholar 

  31. Mueller AS, Pallauf J (2006) J Nutr Biochem 17:548

    Article  PubMed  CAS  Google Scholar 

  32. Salsman HK, Floyd SJ (2005) Antioxid Redox Signal 7:1078

    Article  PubMed  CAS  Google Scholar 

  33. Mueller DB, Koczwara K, Mueller AS et al (2009) Ann Nutr Metab 54:208

    Article  PubMed  CAS  Google Scholar 

  34. Roman M, Lapolla A, Jitaru P et al (2010) Transl Res 156:242

    Google Scholar 

  35. Adachi T, Inoue M, Hara H et al (2004) J Endocrinol 181:413

    Article  PubMed  CAS  Google Scholar 

  36. Kimura F, Hasegawa G, Obayashi H et al (2003) Diabetes Care 26:1246

    Article  PubMed  CAS  Google Scholar 

  37. Tamai M, Furuta H, Kawashima H et al (2006) Diabetes Res Clin Pract 71:140

    Article  PubMed  CAS  Google Scholar 

  38. Mollsten A, Marklund SL, Wessman M et al (2007) Diabetes 56:265

    Article  PubMed  Google Scholar 

  39. Douillet C, Tabib A, Bost M et al (1996) Proc Soc Exp Biol Med 211:323

    PubMed  CAS  Google Scholar 

  40. McClung JP, Roneker CA, Mu W et al (2004) Proc Natl Acad Sci USA 101:8852

    Article  PubMed  CAS  Google Scholar 

  41. Pepper MP, Vatamaniuk MZ, Yan X et al (2011) Antioxid Redox Signal 14:83

    Article  Google Scholar 

  42. Wang X, Vatamaniuk MZ, Roneker CA et al (2011) Antioxid Redox Signal 14:391

    Article  PubMed  Google Scholar 

  43. Chen X, Scholl TO, Leskiw MJ et al (2003) J Clin Endocrinol Metab 88:5963

    Article  PubMed  CAS  Google Scholar 

  44. Li X, Chen H, Epstein PN (2006) Diabetes 55:1592

    Article  PubMed  CAS  Google Scholar 

  45. Speckmann B, Sies H, Steinbrenner H (2009) Biochem Biophys Res Commun 387:158

    Article  PubMed  CAS  Google Scholar 

  46. Stranges S, Marshall JR, Natarajan R et al (2007) Ann Intern Med 147:217

    PubMed  Google Scholar 

  47. Lippman SM, Klein EA, Goodman PJ et al (2009) JAMA 301:39

    Article  PubMed  CAS  Google Scholar 

  48. Stranges S, Sieri S, Vinceti M et al (2010) BMC Public Health 10:564

    Google Scholar 

  49. Bleys J, Navas-Acien A, Guallar E (2007) Ann Intern Med 147:271

    PubMed  Google Scholar 

  50. Laclaustra M, Navas-Acien A, Stranges S et al (2009) Environ Health Perspect 117:1409

    PubMed  CAS  Google Scholar 

  51. Bleys J, Navas-Acien A, Stranges S et al (2008) Am J Clin Nutr 88:416

    PubMed  CAS  Google Scholar 

  52. Laclaustra M, Stranges S, Navas-Acien A et al (2010) Atherosclerosis 210:643

    Google Scholar 

  53. Stranges S, Laclaustra M, Ji C et al (2010) J Nutr 140:81

    Article  PubMed  CAS  Google Scholar 

  54. Yang KC, Lee LT, Lee YS et al (2010) Nutr Metab (Lond) 7:38

    Article  Google Scholar 

  55. Akbaraly TN, Arnaud J, Rayman MP et al (2010) Nutr Metab (Lond) 7:21

    Article  Google Scholar 

  56. Coudray C, Roussel AM, Mainard F et al (1997) J Am Coll Nutr 16:584

    PubMed  CAS  Google Scholar 

  57. Czernichow S, Couthouis A, Bertrais S et al (2006) Am J Clin Nutr 84:395

    PubMed  CAS  Google Scholar 

  58. Kljai K, Runje R (2001) Biol Trace Elem Res 83:223

    Article  PubMed  CAS  Google Scholar 

  59. Navarro-Alarcon M, Lopez G, Perez-Valero V et al (1999) Sci Total Environ 228:79

    Article  PubMed  CAS  Google Scholar 

  60. Rajpathak S, Rimm E, Morris JS et al (2005) J Am Coll Nutr 24:250

    PubMed  CAS  Google Scholar 

  61. Wang XD, Vatamaniuk MZ, Wang SK et al (2008) Diabetologia 51:1515

    Article  PubMed  CAS  Google Scholar 

  62. Rhodes C (2005) Science 307:380

    Article  PubMed  CAS  Google Scholar 

  63. Ahlgren U, Jonsson J, Jonsson L et al (1998) Genes Dev 12:763

    Article  Google Scholar 

  64. Zhao L, Guo M, Matsuoka TA et al (2005) J Biol Chem 280:11887

    Article  PubMed  CAS  Google Scholar 

  65. Olson LK, Sharma A, Peshavaria M et al (1995) Proc Natl Acad Sci USA 92:9127

    Article  PubMed  CAS  Google Scholar 

  66. Kawamori D, Kajimoto Y, Kaneto H et al (2003) Diabetes 52:2896

    Article  PubMed  CAS  Google Scholar 

  67. Boucher MJ, Selander L, Carlsson L et al (2006) J Biol Chem 281:6395

    Article  PubMed  CAS  Google Scholar 

  68. Cross DA, Alessi DR, Cohen P et al (1995) Nature 378:785

    Article  PubMed  CAS  Google Scholar 

  69. Kaytor MD, Orr HT (2002) Curr Opin Neurobiol 12:275

    Article  PubMed  CAS  Google Scholar 

  70. Mosley AL, Corbett JA, Ozcan S (2004) Mol Endocrinol (Baltimore) 18:2279

    Article  CAS  Google Scholar 

  71. Offield MF, Jetton TL, Labosky PA et al (1996) Development 122:983

    PubMed  CAS  Google Scholar 

  72. Ohneda K, Mirmira RG, Wang J et al (2000) Mol Cell Biol 20:900

    Article  PubMed  CAS  Google Scholar 

  73. An W, Palhan VB, Karymov MA et al (2002) Mol Cell 9:811

    Article  PubMed  CAS  Google Scholar 

  74. Lee DY, Hayes JJ, Pruss D et al (1993) Cell 72:73

    Article  PubMed  CAS  Google Scholar 

  75. Norton VG, Marvin KW, Yau P et al (1990) J Biol Chem 265:19848

    PubMed  CAS  Google Scholar 

  76. Lee CS, Sund NJ, Vatamaniuk MZ et al (2002) Diabetes 51:2546

    Article  PubMed  CAS  Google Scholar 

  77. Butler AE, Janson J, Soeller WC et al (2003) Diabetes 52:2304

    Article  PubMed  CAS  Google Scholar 

  78. Federici M, Hribal M, Perego L et al (2001) Diabetes 50:1290

    Article  PubMed  CAS  Google Scholar 

  79. Maechler P, Jornot L, Wollheim CB (1999) J Biol Chem 274:27905

    Article  PubMed  CAS  Google Scholar 

  80. Xu B, Moritz JT, Epstein PN (1999) Free Radic Biol Med 27:830

    Article  PubMed  CAS  Google Scholar 

  81. Chen H, Carlson EC, Pellet L et al (2001) Diabetes 50:2040

    Article  PubMed  CAS  Google Scholar 

  82. Chen H, Li X, Epstein PN (2005) Diabetes 54:1437

    Article  PubMed  CAS  Google Scholar 

  83. Mysore TB, Shinkel TA, Collins J et al (2005) Diabetes 54:2109

    Article  PubMed  CAS  Google Scholar 

  84. Maechler P, Kennedy ED, Pozzan T et al (1997) EMBO J 16:3833

    Article  PubMed  CAS  Google Scholar 

  85. Krauss S, Zhang CY, Scorrano L et al (2003) J Clin Invest 112:1831

    PubMed  CAS  Google Scholar 

  86. Zhang CY, Baffy G, Perret P et al (2001) Cell 105:745

    Article  PubMed  CAS  Google Scholar 

  87. Simon AR, Rai U, Fanburg BL et al (1998) Am J Physiol 275:C1640

    PubMed  CAS  Google Scholar 

  88. Storz G, Tartaglia LA, Ames BN (1990) Science 248:189

    Article  PubMed  CAS  Google Scholar 

  89. Zheng M, Aslund F, Storz G (1998) Science 279:1718

    Article  PubMed  CAS  Google Scholar 

  90. Hayes G, Lockwood D (1987) Proc Natl Acad Sci USA 84:8115

    Article  PubMed  CAS  Google Scholar 

  91. Loh K, Deng H, Fukushima A et al (2009) Cell Metab 10:260

    Article  PubMed  CAS  Google Scholar 

  92. Harmon JS, Bogdani M, Parazzoli SD et al (2009) Endocrinology 150:4855

    Article  PubMed  CAS  Google Scholar 

  93. Mueller AS, Mueller K, Wolf NM et al (2009) Free Radic Res 43:1029

    Article  PubMed  CAS  Google Scholar 

  94. Bravenboer B, Kappelle AC, Hamers FP et al (1992) Diabetologia 35:813

    Article  PubMed  CAS  Google Scholar 

  95. Greene DA, Stevens MJ, Obrosova I et al (1999) Eur J Pharmacol 375:217

    Article  PubMed  CAS  Google Scholar 

  96. Vincent AM, Brownlee M, Russell JW (2002) Ann NY Acad Sci 959:368

    Article  PubMed  CAS  Google Scholar 

  97. Stevens MJ, Obrosova I, Cao X et al (2000) Diabetes 49:1006

    Article  PubMed  CAS  Google Scholar 

  98. Askwith T, Zeng W, Eggo MC et al (2009) Am J Physiol Endocrinol Metab 297:E620

    Article  PubMed  CAS  Google Scholar 

  99. Ayo SH, Radnik RA, Glass WF II et al (1991) Am J Physiol 260:F185

    PubMed  CAS  Google Scholar 

  100. Kunisaki M, Bursell SE, Umeda F et al (1994) Diabetes 43:1372

    Article  PubMed  CAS  Google Scholar 

  101. Obrosova IG, Fathallah L, Stevens MJ (2001) Exp Neurol 172:211

    Article  PubMed  CAS  Google Scholar 

  102. Kakkar R, Kalra J, Mantha SV et al (1995) Mol Cell Biochem 151:113

    Article  PubMed  CAS  Google Scholar 

  103. Chew P, Yuen DY, Stefanovic N et al (2010) Diabetes 59:3198

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgement

The research in the lead author’s laboratory was in part supported by NIH grant DK53018.

Author information

Authors and Affiliations

  1. Department of Animal Science, Cornell University, Ithaca, NY, 14853, USA

    Xin Gen Lei

  2. Department of Medicine, Section on Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA, 02215, USA

    Xiaodan Wang

Authors
  1. Xin Gen Lei
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaodan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xin Gen Lei .

Editor information

Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Lei, X.G., Wang, X. (2011). Glutathione Peroxidase 1 and Diabetes. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_20

Download citation

Publish with us

Policies and ethics

Search

Navigation