Selenium pp 249-259 | Cite as

Selenoproteins in Cardiovascular Redox Pathology



Redox-active selenoproteins, such as the mammalian glutathione peroxidases (GPxs), are essential components of the antioxidant defense systems that serve to limit the damaging accumulation of intracellular and extracellular oxidants. Accumulating evidence from epidemiological and experimental studies indicates that deficiencies in these key antioxidant proteins promote cardiovascular disease and that their excess is often protective against injury and stress. In this chapter, we will examine the role of GPxs in cardiovascular diseases, highlighting their role in modulating vascular function, thrombosis, and atherogenesis.


Keshan Disease Arterial Ischemic Stroke Cerebral Sinovenous Thrombosis Mouse Aortic Endothelial Cell Follow Middle Cerebral Artery Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by NIH grants HL 61795, HV 28178, HL 81587, and HL48743.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Cardiovascular Division, Department of MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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