Skip to main content
SpringerLink
Log in

Selenium Transport in Mammals: Selenoprotein P and Its Receptors

  • Chapter
  • First Online:
Selenium

Abstract

Selenoprotein P (SePP) is a unique selenoprotein in many respects. It carries up to ten selenocysteine moieties, which have been inserted cotranslationally with the help of two separate SECIS elements in its mRNA. The majority of serum SePP is secreted by the liver where hepatocytes convert nutritional selenocompounds into SePP for transport and distribution. Therefore, serum concentration of SePP is a useful biomarker for the selenium status of an individual. Recently, two endocytic receptors, i.e., Lrp2/megalin and Lrp8/ApoE receptor 2, have been identified which participate in target cell-specific SePP uptake and retention. A SePP-cycle has been proposed based on a tissue-specific sequence of reversible biosynthesis, secretion, and reuptake. Brain, testes, and kidney appear to use the SePP-cycle in order to preserve tissue selenium in times of poor nutritional supply. In how far individual genotype differences and common disease signals impair this pathway and disturb normal selenium metabolism and its hierarchical distribution by affecting SePP biosynthesis, secretion of isoforms and reuptake is a central research issue in basic science and biomedicine.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Burk RF, Hill KE (2009) Biochim Biophys Acta 1790:1441

    Article  PubMed  CAS  Google Scholar 

  2. Flohé L (2009) Biochim Biophys Acta 1790:1389

    Article  PubMed  Google Scholar 

  3. Burk RF, Hill KE (2005) Annu Rev Nutr 25:215

    Article  PubMed  CAS  Google Scholar 

  4. Schomburg L, Schweizer U, Köhrle J (2004) Cell Mol Life Sci 61:1988

    Article  PubMed  CAS  Google Scholar 

  5. Moschos MP (2000) Cell Mol Life Sci 57:1836

    Article  PubMed  CAS  Google Scholar 

  6. Mostert V (2000) Arch Biochem Biophys 376:433

    Article  PubMed  CAS  Google Scholar 

  7. Motsenbocker MA, Tappel AL (1982) Biochim Biophys Acta 719:147

    Article  PubMed  CAS  Google Scholar 

  8. Gomez B Jr, Tappel AL (1989) Biochim Biophys Acta 979:20

    Article  PubMed  CAS  Google Scholar 

  9. Yang JG, Hill KE, Burk RF (1989) J Nutr 119:1010

    PubMed  CAS  Google Scholar 

  10. Hill KE, Lloyd RS, Yang JG et al (1991) J Biol Chem 266:10050

    PubMed  CAS  Google Scholar 

  11. Lobanov AV, Hatfield DL, Gladyshev VN (2008) Genome Biol 9:R62

    Article  PubMed  Google Scholar 

  12. Suzuki KT, Ishiwata K, Ogra Y (1999) Analyst 124:1749

    Article  PubMed  CAS  Google Scholar 

  13. Saito Y, Takahashi K (2002) Eur J Biochem 269:5746

    Article  PubMed  CAS  Google Scholar 

  14. Yan J, Barrett JN (1998) J Neurosci 18:8682

    PubMed  CAS  Google Scholar 

  15. Hill KE, Zhou J, McMahan WJ et al (2003) J Biol Chem 278:13640

    Article  PubMed  CAS  Google Scholar 

  16. Schomburg L, Schweizer U, Holtmann B et al (2003) Biochem J 370:397

    Article  PubMed  CAS  Google Scholar 

  17. Olson GE, Winfrey VP, Hill KE et al (2008) J Biol Chem 283:6854

    Article  PubMed  CAS  Google Scholar 

  18. Olson GE, Winfrey VP, Nagdas SK et al (2007) J Biol Chem 282:12290

    Article  PubMed  CAS  Google Scholar 

  19. Burk RF, Hill KE, Olson GE et al (2007) J Neurosci 27:6207

    Article  PubMed  CAS  Google Scholar 

  20. Herz J, Bock HH (2002) Annu Rev Biochem 71:405

    Article  PubMed  CAS  Google Scholar 

  21. Willnow TE, Nykjaer A (2010) Mol Cell Endocrinol 316:93

    Article  PubMed  CAS  Google Scholar 

  22. Christensen EI, Birn H (2002) Nat Rev Mol Cell Biol 3:256

    PubMed  CAS  Google Scholar 

  23. Andreassen TK (2006) Horm Metab Res 38:279

    Article  PubMed  CAS  Google Scholar 

  24. Negri AL (2006) Nephrology (Carlton) 11:510

    Article  CAS  Google Scholar 

  25. Adams JS (2005) Cell 122:647

    Article  PubMed  CAS  Google Scholar 

  26. Homer 800BC Greek Epic Poetry 1

    Google Scholar 

  27. Chiu-Ugalde J, Theilig F, Behrends T et al (2010) Biochem J 431:103

    Article  PubMed  CAS  Google Scholar 

  28. Hirotsune S, Takahara T, Sasaki N et al (1995) Nat Genet 10:77

    Article  PubMed  CAS  Google Scholar 

  29. Trommsdorff M, Gotthardt M, Hiesberger T et al (1999) Cell 97:689

    Article  PubMed  CAS  Google Scholar 

  30. D’Arcangelo G, Miao GG, Chen SC et al (1995) Nature 374:719

    Article  PubMed  Google Scholar 

  31. Schweizer U, Michaelis M, Köhrle J et al (2004) Biochem J 378:21

    Article  PubMed  CAS  Google Scholar 

  32. Olson GE, Winfrey VP, Nagdas SK et al (2005) Biol Reprod 73:201

    Article  PubMed  CAS  Google Scholar 

  33. Renko K, Werner M, Renner-Müller I et al (2008) Biochem J 409:741

    Article  PubMed  CAS  Google Scholar 

  34. Hill KE, Zhou J, McMahan WJ et al (2004) J Nutr 134:157

    PubMed  CAS  Google Scholar 

  35. Schweizer U, Schomburg L, Savaskan NE (2004) J Nutr 134:707

    PubMed  CAS  Google Scholar 

  36. Burk RF, Hill KE, Motley AK et al (2006) Biochim Biophys Acta 1760:1789

    Article  PubMed  CAS  Google Scholar 

  37. Suzuki KT, Kurasaki K, Okazaki N et al (2005) Toxicol Appl Pharmacol 206:1

    Article  PubMed  CAS  Google Scholar 

  38. Willnow TE, Hilpert J, Armstrong SA et al (1996) Proc Natl Acad Sci USA 93:8460

    Article  PubMed  CAS  Google Scholar 

  39. Zarbalis K, May SR, Shen Y et al (2004) PLoS Biol 2:E219

    Article  PubMed  Google Scholar 

  40. Andersen OM, Yeung CH, Vorum H et al (2003) J Biol Chem 278:23989

    Article  PubMed  CAS  Google Scholar 

  41. Ursini F, Heim S, Kiess M et al (1999) Science 285:1393

    Article  PubMed  CAS  Google Scholar 

  42. Kehr S, Malinouski M, Finney L et al (2009) J Mol Biol 389:808

    Article  PubMed  CAS  Google Scholar 

  43. Saito Y, Sato N, Hirashima M et al (2004) Biochem J 381:841

    Article  PubMed  CAS  Google Scholar 

  44. Takebe G, Yarimizu J, Saito Y et al (2002) J Biol Chem 277:41254

    Article  PubMed  CAS  Google Scholar 

  45. Hill KE, Zhou J, Austin LM et al (2007) J Biol Chem 282:10972

    Article  PubMed  CAS  Google Scholar 

  46. Burk RF, Hill KE, Read R et al (1991) Am J Physiol 261:E26

    PubMed  CAS  Google Scholar 

  47. Burk RF, Early DS, Hill KE et al (1998) Hepatology 27:794

    Article  PubMed  CAS  Google Scholar 

  48. Dreher I, Schmutzler C, Jakob F et al (1997) J Trace Elem Med Biol 11:83

    Article  PubMed  CAS  Google Scholar 

  49. Carlson BA, Novoselov SV, Kumaraswamy E et al (2004) J Biol Chem 279:8011

    Article  PubMed  CAS  Google Scholar 

  50. Schweizer U, Streckfuss F, Pelt P et al (2005) Biochem J 386:221

    Article  PubMed  CAS  Google Scholar 

  51. Scharpf M, Schweizer U, Arzberger T et al (2007) J Neural Transm 114:877

    Article  PubMed  CAS  Google Scholar 

  52. Bellinger FP, He QP, Bellinger MT et al (2008) J Alzheimers Dis 15:465

    PubMed  CAS  Google Scholar 

  53. Willnow TE, Nykjaer A, Herz J (1999) Nat Cell Biol 1:E157

    Article  PubMed  CAS  Google Scholar 

  54. Leheste JR, Melsen F, Wellner M et al (2003) FASEB J 17:247

    PubMed  CAS  Google Scholar 

  55. Dreher I, Jakobs TC, Köhrle J (1997) J Biol Chem 272:29364

    Article  PubMed  CAS  Google Scholar 

  56. Speckmann B, Pinto A, Winter M et al (2010) Free Radic Biol Med 49:777

    Article  PubMed  CAS  Google Scholar 

  57. Mostert V, Dreher I, Köhrle J et al (2001) Biofactors 14:135

    Article  PubMed  CAS  Google Scholar 

  58. Speckmann B, Walter PL, Alili L et al (2008) Hepatology 48:1998

    Article  PubMed  CAS  Google Scholar 

  59. Speckmann B, Sies H, Steinbrenner H (2009) Biochem Biophys Res Commun 387:158

    Article  PubMed  CAS  Google Scholar 

  60. Misu H, Takamura T, Takayama H et al (2010) Cell Metab 12:483

    Article  PubMed  CAS  Google Scholar 

  61. McClung JP, Roneker CA, Mu W et al (2004) Proc Natl Acad Sci USA 101:8852

    Article  PubMed  CAS  Google Scholar 

  62. Ashton K, Hooper L, Harvey LJ et al (2009) Am J Clin Nutr 89:2025S

    Article  PubMed  CAS  Google Scholar 

  63. Xia Y, Hill KE, Byrne DW et al (2005) Am J Clin Nutr 81:829

    PubMed  CAS  Google Scholar 

  64. Burk RF, Norsworthy BK, Hill KE et al (2006) Cancer Epidemiol Biomarkers Prev 15:804

    Article  PubMed  CAS  Google Scholar 

  65. Méplan C, Crosley LK, Nicol F et al (2007) FASEB J 21:3063

    Article  PubMed  CAS  Google Scholar 

  66. Peters U, Chatterjee N, Hayes RB et al (2008) Cancer Epidemiol Biomarkers Prev 17:1144

    Article  PubMed  CAS  Google Scholar 

  67. Cooper ML, Adami HO, Gronberg H et al (2008) Cancer Res 68:10171

    Article  PubMed  CAS  Google Scholar 

  68. Méplan C, Hughes DJ, Pardini B et al (2010) Carcinogenesis 31:1074

    Article  PubMed  CAS  Google Scholar 

  69. Steinbrecher A, Méplan C, Hesketh J et al (2010) Cancer Epidemiol Biomarkers Prev

    Google Scholar 

  70. Mörk H, al-Taie OH, Bähr K et al (2000) Nutr Cancer 37:108

    Article  PubMed  Google Scholar 

  71. Calvo A, Xiao N, Kang J et al (2002) Cancer Res 62:5325

    PubMed  CAS  Google Scholar 

  72. Al-Taie OH, Uceyler N, Eubner U et al (2004) Nutr Cancer 48:6

    Article  PubMed  CAS  Google Scholar 

  73. Li CL, Nan KJ, Tian T et al (2007) World J Gastroenterol 13:2363

    PubMed  CAS  Google Scholar 

  74. Lippman SM, Klein EA, Goodman PJ et al (2009) JAMA 301:39

    Article  PubMed  CAS  Google Scholar 

  75. Hercberg S, Preziosi P, Briancon S et al (1998) Control Clin Trials 19:336

    Article  PubMed  CAS  Google Scholar 

  76. Schnabel R, Lubos E, Messow CM et al (2008) Am Heart J 156(1201):e1

    PubMed  Google Scholar 

  77. Zhang S, Rocourt C, Cheng WH (2010) Mech Ageing Dev 131:253

    Article  PubMed  CAS  Google Scholar 

  78. Tonelli M, Wiebe N, Hemmelgarn B et al (2009) BMC Med 7:25

    Article  PubMed  Google Scholar 

  79. Geoghegan M, McAuley D, Eaton S et al (2006) Curr Opin Crit Care 12:136

    Article  PubMed  Google Scholar 

  80. Dumitrescu AM, Liao XH, Abdullah MS et al (2005) Nat Genet 37:1247

    Article  PubMed  CAS  Google Scholar 

  81. Azevedo MF, Barra GB, Naves LA et al (2010) J Clin Endocrinol Metab 95:4066

    Article  PubMed  CAS  Google Scholar 

  82. Schoenmakers E, Agostini M, Mitchell C et al (2010) J Clin Invest 120:4220

    Article  PubMed  CAS  Google Scholar 

  83. Agamy O, Ben Zeev B, Lev D et al (2010) Am J Hum Genet 87:538

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

Work in the authors’ labs is supported by the German Research Foundation (DFG: GraKo 1208/2, Scho 849/2-2) and German Cancer Aid (Deutsche Krebshilfe, 10-1792 Scho2, 108 426).

Author information

Authors and Affiliations

  1. Institute for Experimental Endocrinology, Campus Virchow-Klinikum, Charité-University Medicine Berlin, 13353, Berlin, Germany

    Josef Köhrle, Ulrich Schweizer & Lutz Schomburg

Authors
  1. Josef Köhrle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ulrich Schweizer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lutz Schomburg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Josef Köhrle .

Editor information

Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Köhrle, J., Schweizer, U., Schomburg, L. (2011). Selenium Transport in Mammals: Selenoprotein P and Its Receptors. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_16

Download citation

Publish with us

Policies and ethics

Search

Navigation