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Ordered Mesoporous Silica for the Delivery of Poorly Soluble Drugs

  • Michiel Van Speybroeck
  • Randy Mellaerts
  • Johan Adriaan Martens
  • Pieter Annaert
  • Guy Van den Mooter
  • Patrick Augustijns
Chapter
Part of the Advances in Delivery Science and Technology book series (ADST)

Abstract

Ordered mesoporous silica (OMS) materials offer much promise as carriers for poorly soluble drugs because of their high porosity, large specific surface area, and uniform pore shape and dimensions. Liquid as well as solid type phases of drugs, confined and stabilized in the pores of OMS, can exhibit special physicochemical properties and enhanced dissolution rates compared to crystalline forms. The ability to design mesopore size precisely provides the formulation scientist with the potential to readily attain and closely control drug release. Absorption enhancement may require stable supersaturation of released drug. If this can be effected (viz. drug precipitation attenuated by suitable formulation adjuvants), systemic absorption can be enhanced. In vivo proof of concept of OMS as a dissolution-enhancing technology has been demonstrated in various animal species. The findings are promising and suggest that adsorption on OMS can successfully enhance and control absorption of poorly soluble drugs.

Keywords

Drug Release Fumed Silica Solid Dispersion Silica Surface Soluble Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors acknowledge the Flemish Government for financial support from the Industrial Research Fund (IOF). MVS acknowledges the Flemish Institute for the Promotion of Innovation through Science and Technology (IWT-Vlaanderen) for a PhD grant. RM acknowledges the Research Fund-Flanders (FWO- Vlaanderen) for a postdoctoral research fellowship. JAM acknowledges the Flemish Government for long-term structural funding (Methusalem).

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Copyright information

© Controlled Release Society 2011

Authors and Affiliations

  • Michiel Van Speybroeck
    • 1
  • Randy Mellaerts
    • 2
  • Johan Adriaan Martens
    • 2
  • Pieter Annaert
    • 1
  • Guy Van den Mooter
    • 1
  • Patrick Augustijns
    • 1
  1. 1.Laboratory for Pharmacotechnology and BiopharmacyKatholieke Universiteit LeuvenLeuvenBelgium
  2. 2.Center for Surface Chemistry and CatalysisKatholieke Universiteit LeuvenLeuvenBelgium

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