The Role of Caveolin-1 in Skin Cancer
Caveolin-1 (Cav-1) expression in human cancer has extensively been documented in cell lines and primary tumors. Type and stage of tumor often modulates Cav-1 levels, which results in either down or upregulation depending on cancer types. Among all skin cancers, melanoma is by far the most regulated by Cav-1. The role of Cav-1 in tumor progression of primary and metastatic melanoma appears discordant since it can stimulate or inhibit tumor growth. Studies on Cav-1 signaling in different tumor types can reveal exploitable analogies useful to better interpret the behavior of Cav-1 in melanoma. We have originally characterized Cav-1-containing exosomes in human melanoma cell lines, described their fusion ability with target cells, and their adaptability to low micro enviromental pH. These nano scale cell-secreted vesicles contain Cav-1 and a number of melanoma progression markers, which can also be traced into the plasma of poor prognosis patients affected by melanoma.
KeywordsMigration Tyrosine Acidity Integrin Cytosol
We thank G. Loreto for preparation of the figures. This work was partially supported by the Italian Ministry of Health (to MS and AC) and by the Italian Association for Cancer Research to AC.