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Ptosis in Neurologic Disease

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Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery

Abstract

“Ptosis,” derived from the Greek word “fall,” is the abnormal lowering or prolapse of a structure; blepharoptosis refers to a lowering of the upper eyelid [1]. The normal position of the upper eyelid is dependent on the gender and ethnicity of each individual [2, 3]. The true frequency of ptosis and its particular subtypes is not known. A recent review of 484 cases of ptosis repair, excluding pseudoptosis, cited myogenic as the most common subgroup (42%), followed closely by aponeurotic (35.3%), and then “mixed” (15.9%). Neurogenic etiologies made up a minority of cases (6.8%) [4].

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References

  1. The American Heritage Dictionary of the English Language. 4th ed. Boston: Houghton Mifflin; 2000.

    Google Scholar 

  2. Murchison AP, Sires BA, Jian-Amadi A. Margin reflex distance in different ethnic groups. Arch Facial Plast Surg. 2009;11(5):303–5.

    PubMed  Google Scholar 

  3. Price KM, Gupta PK, Woodward JA, et al. Eyebrow and eyelid dimensions: an anthropometric analysis of African Americans and Caucasians. Plast Reconstr Surg. 2009;124(2):615–23.

    CAS  PubMed  Google Scholar 

  4. Baggio E, Ruban JM, Boizard Y. Etiologic causes of ptosis about a serie of 484 cases. To a new classification? J Fr Ophthalmol. 2002;25(10):1015–20.

    CAS  Google Scholar 

  5. Nerad J. Evaluation and treatment of the patient with ptosis. In: Krachner JH, editor. Oculoplastic surgery the requisites in ophthalmology. St. Louis: Mosby; 2001.

    Google Scholar 

  6. Putman JR, Nunery WR, Tanenbaum M, McCord Jr CD. Blepharoptosis. In: McCord Jr CD, Tanebaum M, Nunery WR, editors. Oculoplastic surgery. New York: Raven Press; 1995.

    Google Scholar 

  7. Lam BL, Thompson HS, Corbett JJ. The prevalence of simple anisocoria. Am J Ophthalmol. 1987;104(1):69–73.

    CAS  PubMed  Google Scholar 

  8. Moeller JJ, Maxner CE. The dilated pupil: an update. Curr Neurol Neurosci Rep. 2007;7(5):417–22.

    PubMed  Google Scholar 

  9. Bartley GB. The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota. Trans Am Ophthalmol Soc. 1994;92:477–588.

    CAS  PubMed Central  PubMed  Google Scholar 

  10. Bartley GB. The differential diagnosis and classification of eyelid retraction. Ophthalmology. 1996;103(1):168–76.

    CAS  PubMed  Google Scholar 

  11. Chang EL, Rubin PA. Upper and lower eyelid retraction. Int Ophthalmol Clin. 2002;42(2):45–59.

    PubMed  Google Scholar 

  12. Bartley GB, Fatourechi V, Kadrmas EF, et al. Chronology of Graves’ ophthalmopathy in an incidence cohort. Am J Ophthalmol. 1996;121(4):426–34.

    CAS  PubMed  Google Scholar 

  13. Rubin PA, Rumelt S. Functional indications for enophthalmos repair. Ophthal Plast Reconstr Surg. 1999;15(4):284–92.

    CAS  PubMed  Google Scholar 

  14. Cline RA, Rootman J. Enophthalmos: a clinical review. Ophthalmology. 1984;91(3):229–37.

    CAS  PubMed  Google Scholar 

  15. Mattacks CA, Pond CM. The effects of dietary restriction and exercise on the volume of adipocytes in two intra-orbital depots in the guinea-pig. Br J Nutr. 1985;53(2):207–13.

    CAS  PubMed  Google Scholar 

  16. Athanasiov PA, Prabhakaran VC, Selva D. Non-traumatic enophthalmos: a review. Acta Ophthalmol. 2008;86(4):356–64.

    PubMed  Google Scholar 

  17. Shields CL, Stopyra GA, Marr BP, et al. Enophthalmos as initial manifestation of occult, mammogram-negative carcinoma of the breast. Ophthalmic Surg Lasers Imaging. 2004;35(1):56–7.

    PubMed  Google Scholar 

  18. Goldberg RA, Rootman J. Clinical characteristics of metastatic orbital tumors. Ophthalmology. 1990;97(5):620–4.

    CAS  PubMed  Google Scholar 

  19. Soparkar CN, Patrinely JR, Cuaycong MJ, et al. The silent sinus syndrome. A cause of spontaneous enophthalmos. Ophthalmology. 1994;101(4):772–8.

    CAS  PubMed  Google Scholar 

  20. Ficker LA, Collin JR, Lee JP. Management of ipsilateral ptosis with hypotropia. Br J Ophthalmol. 1986;70(10):732–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  21. Hallett M, Evinger C, Jankovic J, Stacy M. Update on blepharospasm: report from the BEBRF international workshop. Neurology. 2008;71(16):1275–82.

    PubMed Central  PubMed  Google Scholar 

  22. Frueh BR, Musch DC. Treatment of facial spasm with botulinum toxin. An interim report. Ophthalmology. 1986;93(7):917–23.

    CAS  PubMed  Google Scholar 

  23. Etgen T, Muhlau M, Gaser C, Sander D. Bilateral grey-matter increase in the putamen in primary blepharospasm. J Neurol Neurosurg Psychiatry. 2006;77(9):1017–20.

    CAS  PubMed Central  PubMed  Google Scholar 

  24. Obermann M, Yaldizli O, De Greiff A, et al. Morphometric changes of sensorimotor structures in focal dystonia. Mov Disord. 2007;22(8):1117–23.

    PubMed  Google Scholar 

  25. Colosimo C, Pantano P, Calistri V, et al. Diffusion tensor imaging in primary cervical dystonia. J Neurol Neurosurg Psychiatry. 2005;76(11):1591–3.

    CAS  PubMed Central  PubMed  Google Scholar 

  26. Kerrison JB, Lancaster JL, Zamarripa FE, et al. Positron emission tomography scanning in essential blepharospasm. Am J Ophthalmol. 2003;136(5):846–52.

    PubMed  Google Scholar 

  27. Suzuki Y, Mizoguchi S, Kiyosawa M, et al. Glucose hypermetabolism in the thalamus of patients with essential blepharospasm. J Neurol. 2007;254(7):890–6.

    PubMed  Google Scholar 

  28. Nakashima K, Kusumi M, Inoue Y, Takahashi K. Prevalence of focal dystonias in the western area of Tottori Prefecture in Japan. Mov Disord. 1995;10(4):440–3.

    CAS  PubMed  Google Scholar 

  29. Nutt JG, Muenter MD, Aronson A, et al. Epidemiology of focal and generalized dystonia in Rochester, Minnesota. Mov Disord. 1988;3(3):188–94.

    CAS  PubMed  Google Scholar 

  30. Epidemiological Study of Dystonia in Europe (ESDE) Collaborative Group. A prevalence study of primary dystonia in eight European countries. J Neurol. 2000;247(10):787–92.

    Google Scholar 

  31. Epidemiologic Study of Dystonia in Europe (ESDE) Collaborative Group. Sex-related influences on the frequency and age of onset of primary dystonia. Neurology. 1999;53(8):1871–3.

    Google Scholar 

  32. Defazio G, Berardelli A, Abbruzzese G, et al. Possible risk factors for primary adult onset dystonia: a case-control investigation by the Italian movement disorders study group. J Neurol Neurosurg Psychiatry. 1998;64(1):25–32.

    CAS  PubMed Central  PubMed  Google Scholar 

  33. Hallett M, Daroff RB. Blepharospasm: report of a workshop. Neurology. 1996;46(5):1213–8.

    CAS  PubMed  Google Scholar 

  34. Defazio G, Martino D, Aniello MS, et al. A family study on primary blepharospasm. J Neurol Neurosurg Psychiatry. 2006;77(2):252–4.

    CAS  PubMed Central  PubMed  Google Scholar 

  35. Seiff SR, Zwick OM. Botulinum toxin management of upper facial rhytidosis and blepharospasm. Otolaryngol Clin North Am. 2005;38(5):887–902.

    PubMed  Google Scholar 

  36. Defazio G, Berardelli A, Abbruzzese G, et al. Risk factors for spread of primary adult onset blepharospasm: a multicentre investigation of the Italian movement disorders study group. J Neurol Neurosurg Psychiatry. 1999;67(5):613–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  37. Kanazawa M, Shimohata T, Sato M, et al. Botulinum toxin A injections improve apraxia of eyelid opening without overt blepharospasm associated with neurodegenerative diseases. Mov Disord. 2007;22(4):597–8.

    PubMed  Google Scholar 

  38. Lamberti P, De Mari M, Zenzola A, et al. Frequency of apraxia of eyelid opening in the general population and in patients with extrapyramidal disorders. Neurol Sci. 2002;23(Suppl 2):S81–2.

    PubMed  Google Scholar 

  39. Krack P, Marion MH. “Apraxia of lid opening”, a focal eyelid dystonia: clinical study of 32 patients. Mov Disord. 1994;9(6):610–5.

    CAS  PubMed  Google Scholar 

  40. Boghen D. Apraxia of lid opening: a review. Neurology. 1997;48(6):1491–4.

    CAS  PubMed  Google Scholar 

  41. Defazio G, Livrea P, Lamberti P, et al. Isolated so-called apraxia of eyelid opening: report of 10 cases and a review of the literature. Eur Neurol. 1998;39(4):204–10.

    CAS  PubMed  Google Scholar 

  42. Cherian V, Foroozan R. Benign unilateral apraxia of eyelid opening. Ophthalmology. 2010;117(6):1265–8.

    PubMed  Google Scholar 

  43. Jordan DR, Anderson RL, Digre KB. Apraxia of lid opening in blepharospasm. Ophthalmic Surg. 1990;21(5):331–4.

    CAS  PubMed  Google Scholar 

  44. Kerty E, Eidal K. Apraxia of eyelid opening: clinical features and therapy. Eur J Ophthalmol. 2006;16(2):204–8.

    CAS  PubMed  Google Scholar 

  45. Holds JB, Anderson RL, Jordan DR, Patrinely JR. Bilateral hemifacial spasm. J Clin Neuroophthalmol. 1990;10(2):153–4.

    CAS  PubMed  Google Scholar 

  46. Auger RG, Whisnant JP. Hemifacial spasm in Rochester and Olmsted County, Minnesota, 1960 to 1984. Arch Neurol. 1990;47(11):1233–4.

    CAS  PubMed  Google Scholar 

  47. Bernardi B, Zimmerman RA, Savino PJ, Adler C. Magnetic resonance tomographic angiography in the investigation of hemifacial spasm. Neuroradiology. 1993;35(8):606–11.

    CAS  PubMed  Google Scholar 

  48. Hosoya T, Watanabe N, Yamaguchi K, et al. Three-dimensional-MRI of neurovascular compression in patients with hemifacial spasm. Neuroradiology. 1995;37(5):350–2.

    CAS  PubMed  Google Scholar 

  49. Nielsen VK, Jannetta PJ. Pathophysiology of hemifacial spasm: III. Effects of facial nerve decompression. Neurology. 1984;34(7):891–7.

    CAS  PubMed  Google Scholar 

  50. Nielsen VK. Pathophysiology of hemifacial spasm: II. Lateral spread of the supraorbital nerve reflex. Neurology. 1984;34(4):427–31.

    CAS  PubMed  Google Scholar 

  51. Nielsen VK. Pathophysiology of hemifacial spasm: I. Ephaptic transmission and ectopic excitation. Neurology. 1984;34(4):418–26.

    CAS  PubMed  Google Scholar 

  52. Matsuura N, Kondo A. Trigeminal neuralgia and hemifacial spasm as false localizing signs in patients with a contralateral mass of the posterior cranial fossa. Report of three cases. J Neurosurg. 1996;84(6):1067–71.

    CAS  PubMed  Google Scholar 

  53. Nagata S, Matsushima T, Fujii K, et al. Hemifacial spasm due to tumor, aneurysm, or arteriovenous malformation. Surg Neurol. 1992;38(3):204–9.

    CAS  PubMed  Google Scholar 

  54. Wang A, Jankovic J. Hemifacial spasm: clinical findings and treatment. Muscle Nerve. 1998;21(12):1740–7.

    CAS  PubMed  Google Scholar 

  55. Koutsis G, Kokotis P, Sarrigiannis P, et al. Spastic paretic hemifacial contracture in multiple sclerosis: a neglected clinical and EMG entity. Mult Scler. 2008;14(7):927–32.

    CAS  PubMed  Google Scholar 

  56. Krauss JK, Wakhloo AK, Scheremet R, Seeger W. Facial myokymia and spastic paretic facial contracture as the result of anaplastic pontocerebellar glioma. Neurosurgery. 1993;32(6):1031–4.

    CAS  PubMed  Google Scholar 

  57. Savino PJ, Maus M. Botulinum toxin therapy. Neurol Clin. 1991;9(1):205–24.

    CAS  PubMed  Google Scholar 

  58. Simpson DM, Blitzer A, Brashear A, et al. Assessment: botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American academy of neurology. Neurology. 2008;70(19):1699–706.

    CAS  PubMed  Google Scholar 

  59. Blackburn MK, Lamb RD, Digre KB, et al. FL-41 tint improves blink frequency, light sensitivity, and functional limitations in patients with benign essential blepharospasm. Ophthalmology. 2009;116(5):997–1001.

    PubMed Central  PubMed  Google Scholar 

  60. Chapman KL, Bartley GB, Waller RR, Hodge DO. Follow-up of patients with essential blepharospasm who underwent eyelid protractor myectomy at the Mayo Clinic from 1980 through 1995. Ophthal Plast Reconstr Surg. 1999;15(2):106–10.

    CAS  PubMed  Google Scholar 

  61. Grivet D, Robert PY, Thuret G, et al. Assessment of blepharospasm surgery using an improved disability scale: study of 138 patients. Ophthal Plast Reconstr Surg. 2005;21(3):230–4.

    PubMed  Google Scholar 

  62. Nicoletti AG, Pereira IC, Matayoshi S. Browlifting as an alternative procedure for apraxia of eyelid opening. Ophthal Plast Reconstr Surg. 2009;25(1):46–7.

    PubMed  Google Scholar 

  63. Fante RG, Frueh BR. Differential section of the seventh nerve as a tertiary procedure for the treatment of benign essential blepharospasm. Ophthal Plast Reconstr Surg. 2001;17(4):276–80.

    CAS  PubMed  Google Scholar 

  64. Barker 2nd FG, Jannetta PJ, Bissonette DJ, et al. Microvascular decompression for hemifacial spasm. J Neurosurg. 1995;82(2):201–10.

    PubMed  Google Scholar 

  65. Artz GJ, Hux FJ, Larouere MJ, et al. Endoscopic vascular decompression. Otol Neurotol. 2008;29(7):995–1000.

    PubMed  Google Scholar 

  66. Pfaffenbach DD, Cross HE, Kearns TP. Congenital anomalies in Duane’s retraction syndrome. Arch Ophthalmol. 1972;88(6):635–9.

    CAS  PubMed  Google Scholar 

  67. DeRespinis PA, Caputo AR, Wagner RS, Guo S. Duane’s retraction syndrome. Surv Ophthalmol. 1993;38(3):257–88.

    CAS  PubMed  Google Scholar 

  68. Raab EL. Clinical features of Duane’s syndrome. J Pediatr Ophthalmol Strabismus. 1986;23(2):64–8.

    CAS  PubMed  Google Scholar 

  69. Huber A. Electrophysiology of the retraction syndromes. Br J Ophthalmol. 1974;58(3):293–300.

    CAS  PubMed Central  PubMed  Google Scholar 

  70. Alexandrakis G, Saunders RA. Duane retraction syndrome. Ophthalmol Clin North Am. 2001;14(3):407–17.

    CAS  PubMed  Google Scholar 

  71. Fowler AM, Dutton JJ. Floppy eyelid syndrome as a subset of lax eyelid conditions: relationships and clinical relevance (an ASOPRS thesis). Ophthal Plast Reconstr Surg. 2010;26(3):195–204.

    PubMed  Google Scholar 

  72. Taban M, Perry JD. Plasma leptin levels in patients with floppy eyelid syndrome. Ophthal Plast Reconstr Surg. 2006;22(5):375–7.

    PubMed  Google Scholar 

  73. Schlotzer-Schrehardt U, Stojkovic M, Hofmann-Rummelt C, et al. The pathogenesis of floppy eyelid syndrome: involvement of matrix metalloproteinases in elastic fiber degradation. Ophthalmology. 2005;112(4):694–704.

    PubMed  Google Scholar 

  74. Goldberg R, Seiff S, McFarland J, et al. Floppy eyelid syndrome and blepharochalasis. Am J Ophthalmol. 1986;102(3):376–81.

    CAS  PubMed  Google Scholar 

  75. McNab AA. Floppy eyelid syndrome and obstructive sleep apnea. Ophthal Plast Reconstr Surg. 1997;13(2):98–114.

    CAS  PubMed  Google Scholar 

  76. Langford JD, Linberg JV. A new physical finding in floppy eyelid syndrome. Ophthalmology. 1998;105(1):165–9.

    CAS  PubMed  Google Scholar 

  77. Culbertson WW, Tseng SC. Corneal disorders in floppy eyelid syndrome. Cornea. 1994;13(1):33–42.

    CAS  PubMed  Google Scholar 

  78. Dutton JJ. Surgical management of floppy eyelid syndrome. Am J Ophthalmol. 1985;99(5):557–60.

    CAS  PubMed  Google Scholar 

  79. Katusic SK, Beard CM, Wiederholt WC, et al. Incidence, clinical features, and prognosis in Bell’s palsy, Rochester, Minnesota, 1968–1982. Ann Neurol. 1986;20(5):622–7.

    CAS  PubMed  Google Scholar 

  80. Kimura J, Rodnitzky RL, Okawara SH. Electrophysiologic analysis of aberrant regeneration after facial nerve paralysis. Neurology. 1975;25(10):989–93.

    CAS  PubMed  Google Scholar 

  81. Celik M, Forta H, Vural C. The development of synkinesis after facial nerve paralysis. Eur Neurol. 2000;43(3):147–51.

    CAS  PubMed  Google Scholar 

  82. Yamamoto E, Nishimura H, Hirono Y. Occurrence of sequelae in Bell’s palsy. Acta Otolaryngol Suppl. 1988;446:93–6.

    CAS  PubMed  Google Scholar 

  83. Moran CJ, Neely JG. Patterns of facial nerve synkinesis. Laryngoscope. 1996;106(12 Pt 1):1491–6.

    CAS  PubMed  Google Scholar 

  84. Rijntjes M, Tegenthoff M, Liepert J, et al. Cortical reorganization in patients with facial palsy. Ann Neurol. 1997;41(5):621–30.

    CAS  PubMed  Google Scholar 

  85. Valls-Sole J, Montero J. Movement disorders in patients with peripheral facial palsy. Mov Disord. 2003;18(12):1424–35.

    PubMed  Google Scholar 

  86. Keegan DJ, Geerling G, Lee JP, et al. Botulinum toxin treatment for hyperlacrimation secondary to aberrant regenerated seventh nerve palsy or salivary gland transplantation. Br J Ophthalmol. 2002;86(1):43–6.

    PubMed Central  PubMed  Google Scholar 

  87. Lee V, Currie Z, Collin JR. Ophthalmic management of facial nerve palsy. Eye (Lond). 2004;18(12):1225–34.

    CAS  Google Scholar 

  88. VanSwearingen JM, Brach JS. Changes in facial movement and synkinesis with facial neuromuscular reeducation. Plast Reconstr Surg. 2003;111(7):2370–5.

    PubMed  Google Scholar 

  89. Cronin GW, Steenerson RL. The effectiveness of neuromuscular facial retraining combined with electromyography in facial paralysis rehabilitation. Otolaryngol Head Neck Surg. 2003;128(4):534–8.

    PubMed  Google Scholar 

  90. Demer JL, Clark RA, Engle EC. Magnetic resonance imaging evidence for widespread orbital dysinnervation in congenital fibrosis of extraocular muscles due to mutations in KIF21A. Invest Ophthalmol Vis Sci. 2005;46(2):530–9.

    PubMed  Google Scholar 

  91. Engle EC, Goumnerov BC, McKeown CA, et al. Oculomotor nerve and muscle abnormalities in congenital fibrosis of the extraocular muscles. Ann Neurol. 1997;41(3):314–25.

    CAS  PubMed  Google Scholar 

  92. Engle EC. The genetic basis of complex strabismus. Pediatr Res. 2006;59(3):343–8.

    PubMed  Google Scholar 

  93. Egan RA, Kerrison JB. Survey of genetic neuro-ophthalmic disorders. Ophthalmol Clin North Am. 2003;16(4):595–605, vii.

    PubMed  Google Scholar 

  94. Engle EC, Kunkel LM, Specht LA, Beggs AH. Mapping a gene for congenital fibrosis of the extraocular muscles to the centromeric region of chromosome 12. Nat Genet. 1994;7(1):69–73.

    CAS  PubMed  Google Scholar 

  95. Wang SM, Zwaan J, Mullaney PB, et al. Congenital fibrosis of the extraocular muscles type 2, an inherited exotropic strabismus fixus, maps to distal 11q13. Am J Hum Genet. 1998;63(2):517–25.

    CAS  PubMed Central  PubMed  Google Scholar 

  96. Engle EC, Marondel I, Houtman WA, et al. Congenital fibrosis of the extraocular muscles (autosomal dominant congenital external ophthalmoplegia): genetic homogeneity, linkage refinement, and physical mapping on chromosome 12. Am J Hum Genet. 1995;57(5):1086–94.

    CAS  PubMed Central  PubMed  Google Scholar 

  97. Aubourg P, Krahn M, Bernard R, et al. Assignment of a new congenital fibrosis of extraocular muscles type 3 (CFEOM3) locus, FEOM4, based on a balanced translocation t(2;13) (q37.3;q12.11) and identification of candidate genes. J Med Genet. 2005;42(3):253–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  98. Doherty EJ, Macy ME, Wang SM, et al. CFEOM3: a new extraocular congenital fibrosis syndrome that maps to 16q24.2-q24.3. Invest Ophthalmol Vis Sci. 1999;40(8):1687–94.

    CAS  PubMed  Google Scholar 

  99. Heidary G, Engle EC, Hunter DG. Congenital fibrosis of the extraocular muscles. Semin Ophthalmol. 2008;23(1):3–8.

    PubMed  Google Scholar 

  100. Harley RD, Rodrigues MM, Crawford JS. Congenital fibrosis of the extraocular muscles. J Pediatr Ophthalmol Strabismus. 1978;15(6):346–58.

    CAS  PubMed  Google Scholar 

  101. MOxley 3rd RT. Proximal myotonic myopathy: mini-review of a recently delineated clinical disorder. Neuromuscul Disord. 1996;6(2):87–93.

    PubMed  Google Scholar 

  102. Day JW, Ricker K, Jacobsen JF, et al. Myotonic dystrophy type 2: molecular, diagnostic and clinical spectrum. Neurology. 2003;60(4):657–64.

    CAS  PubMed  Google Scholar 

  103. Ranum LP, Day JW. Myotonic dystrophy: RNA pathogenesis comes into focus. Am J Hum Genet. 2004;74(5):793–804.

    CAS  PubMed Central  PubMed  Google Scholar 

  104. Mathieu J, Allard P, Potvin L, et al. A 10-year study of mortality in a cohort of patients with myotonic dystrophy. Neurology. 1999;52(8):1658–62.

    CAS  PubMed  Google Scholar 

  105. Brais B, Xie YG, Sanson M, et al. The oculopharyngeal muscular dystrophy locus maps to the region of the cardiac alpha and beta myosin heavy chain genes on chromosome 14q11.2-q13. Hum Mol Genet. 1995;4(3):429–34.

    CAS  PubMed  Google Scholar 

  106. Blumen SC, Nisipeanu P, Sadeh M, et al. Epidemiology and inheritance of oculopharyngeal muscular dystrophy in Israel. Neuromuscul Disord. 1997;7(Suppl 1):S38–40.

    PubMed  Google Scholar 

  107. Brunet G, Tome FM, Eymard B, et al. Genealogical study of oculopharyngeal muscular dystrophy in France. Neuromuscul Disord. 1997;7(Suppl 1):S34–7.

    PubMed  Google Scholar 

  108. Grewal RP, Karkera JD, Grewal RK, Detera-Wadleigh SD. Mutation analysis of oculopharyngeal muscular dystrophy in Hispanic American families. Arch Neurol. 1999;56(11):1378–81.

    CAS  PubMed  Google Scholar 

  109. Becher MW, Morrison L, Davis LE, et al. Oculopharyngeal muscular dystrophy in Hispanic New Mexicans. JAMA. 2001;286(19):2437–40.

    CAS  PubMed  Google Scholar 

  110. Bouchard JP, Brais B, Brunet D, et al. Recent studies on oculopharyngeal muscular dystrophy in Quebec. Neuromuscul Disord. 1997;7(Suppl 1):S22–9.

    PubMed  Google Scholar 

  111. Victor M, Hayes R, Adams RD. Oculopharyngeal muscular dystrophy. A familial disease of late life characterized by dysphagia and progressive ptosis of the eyelids. N Engl J Med. 1962;267:1267–72.

    CAS  PubMed  Google Scholar 

  112. Murphy SF, Drachman DB. The oculopharyngeal syndrome. JAMA. 1968;203(12):1003–8.

    CAS  PubMed  Google Scholar 

  113. Hill ME, Creed GA, McMullan TF, et al. Oculopharyngeal muscular dystrophy: phenotypic and genotypic studies in a UK population. Brain. 2001;124(Pt 3):522–6.

    CAS  PubMed  Google Scholar 

  114. Brais B, Bouchard JP, Xie YG, et al. Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy. Nat Genet. 1998;18(2):164–7.

    CAS  PubMed  Google Scholar 

  115. Blumen SC, Brais B, Korczyn AD, et al. Homozygotes for oculopharyngeal muscular dystrophy have a severe form of the disease. Ann Neurol. 1999;46(1):115–8.

    CAS  PubMed  Google Scholar 

  116. Ruegg S, Lehky Hagen M, Hohl U, et al. Oculopharyngeal muscular dystrophy – an under-diagnosed disorder? Swiss Med Wkly. 2005;135(39–40):574–86.

    PubMed  Google Scholar 

  117. Rodrigue D, Molgat YM. Surgical correction of blepharoptosis in oculopharyngeal muscular dystrophy. Neuromuscul Disord. 1997;7(Suppl 1):S82–4.

    PubMed  Google Scholar 

  118. Codere F. Oculopharyngeal muscular dystrophy. Can J Ophthalmol. 1993;28(1):1–2.

    CAS  PubMed  Google Scholar 

  119. Caron MJ, Girard F, Girard DC, et al. Cisatracurium pharmacodynamics in patients with oculopharyngeal muscular dystrophy. Anesth Analg. 2005;100(2):393–7.

    CAS  PubMed  Google Scholar 

  120. Edmond JC. Mitochondrial disorders. Int Ophthalmol Clin. 2009;49(3):27–33.

    PubMed  Google Scholar 

  121. Greaves LC, Yu-Wai-Man P, Blakely EL, et al. Mitochondrial DNA defects and selective extraocular muscle involvement in CPEO. Invest Ophthalmol Vis Sci. 2010;51(7):3340–6.

    PubMed Central  PubMed  Google Scholar 

  122. Finsterer J. Mitochondrial disorder mimicking ocular myasthenia. Acta Neurol Belg. 2010;110(1):110–2.

    PubMed  Google Scholar 

  123. Lelli Jr GJ, Musch DC, Frueh BR, Nelson CC. Outcomes in silicone rod frontalis suspension surgery for high-risk noncongenital blepharoptosis. Ophthal Plast Reconstr Surg. 2009;25(5):361–5.

    PubMed  Google Scholar 

  124. Almousa R, Charlton A, Rajesh ST, et al. Optimizing muscle biopsy for the diagnosis of mitochondrial myopathy. Ophthal Plast Reconstr Surg. 2009;25(5):366–70.

    PubMed  Google Scholar 

  125. Lopez-Gallardo E, Lopez-Perez MJ, Montoya J, Ruiz-Pesini E. CPEO and KSS differ in the percentage and location of the mtDNA deletion. Mitochondrion. 2009;9(5):314–7.

    CAS  PubMed  Google Scholar 

  126. Yesil M, Bayata S, Postaci N, Arikan E. Progression of conduction system disease in a paced patient with Kearns-Sayre syndrome. Clin Cardiol. 2009;32(6):E65–7.

    PubMed  Google Scholar 

  127. Gronlund MA, Honarvar AK, Andersson S, et al. Ophthalmological findings in children and young adults with genetically verified mitochondrial disease. Br J Ophthalmol. 2010;94(1):121–7.

    CAS  PubMed  Google Scholar 

  128. Snyder LA, Rismondo V, Miller NR. The Fisher variant of Guillain–Barre syndrome (Fisher syndrome). J Neuroophthalmol. 2009;29(4):312–24.

    PubMed  Google Scholar 

  129. Hughes RA, Cornblath DR. Guillain–Barre syndrome. Lancet. 2005;366(9497):1653–66.

    CAS  PubMed  Google Scholar 

  130. Hughes RA, Swan AV, van Doorn PA. Corticosteroids for Guillain–Barre syndrome. Cochrane Database Syst Rev. 2010;2:CD001446.

    PubMed  Google Scholar 

  131. van der Meche FG, van Doorn PA. Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy: immune mechanisms and update on current therapies. Ann Neurol. 1995;37(Suppl 1):S14–31.

    PubMed  Google Scholar 

  132. Yang YR, Liu SL, Qin ZY, et al. Comparative proteomics analysis of cerebrospinal fluid of patients with Guillain-Barre syndrome. Cell Mol Neurobiol. 2008;28(5):737–44.

    CAS  PubMed  Google Scholar 

  133. Raphael JC, Chevret S, Hughes RA, Annane D. Plasma exchange for Guillain-Barre syndrome. Cochrane Database Syst Rev. 2002;2:CD001798.

    PubMed  Google Scholar 

  134. Hughes RA, Raphael JC, Swan AV, van Doorn PA. Intravenous immunoglobulin for Guillain-Barre syndrome. Cochrane Database Syst Rev. 2006(1):CD002063.

    Google Scholar 

  135. Tan H. Bilateral oculomotor palsy secondary to pseudotumor cerebri. Pediatr Neurol. 2010;42(2):141–2.

    PubMed  Google Scholar 

  136. Bahmani Kashkouli M, Khalatbari MR, Yahyavi ST, et al. Pituitary apoplexy presenting as acute painful isolated unilateral third cranial nerve palsy. Arch Iran Med. 2008;11(4):466–8.

    PubMed  Google Scholar 

  137. Beckmann YY, Deniz B, Gelal F, Secil Y. Third cranial nerve palsy as the presenting neuro-ophthalmic feature of nasopharyngeal carcinoma. J Neuroophthalmol. 2010;30(1):102–3.

    PubMed  Google Scholar 

  138. Beleza P, Machado A, Soares-Fernandes J, et al. Isolated oculomotor nerve paresis as the presenting sign of multiple sclerosis. Arq Neuropsiquiatr. 2008;66(2A):254–5.

    PubMed  Google Scholar 

  139. Brazis PW. Isolated palsies of cranial nerves III, IV, and VI. Semin Neurol. 2009;29(1):14–28.

    PubMed  Google Scholar 

  140. Akagi T, Miyamoto K, Kashii S, Yoshimura N. Cause and prognosis of neurologically isolated third, fourth, or sixth cranial nerve dysfunction in cases of oculomotor palsy. Jpn J Ophthalmol. 2008;52(1):32–5.

    PubMed  Google Scholar 

  141. Cullom ME, Savino PJ, Sergott RC, Bosley TM. Relative pupillary sparing third nerve palsies. To arteriogram or not? J Neuroophthalmol. 1995;15(3):136–40. discussion 40–1.

    CAS  PubMed  Google Scholar 

  142. Trobe JD. The evaluation of horner syndrome. J Neuroophthalmol. 2010;30(1):1–2.

    PubMed  Google Scholar 

  143. Jacobson DM. Pupil involvement in patients with diabetes-associated oculomotor nerve palsy. Arch Ophthalmol. 1998;116(6):723–7.

    CAS  PubMed  Google Scholar 

  144. Jacobson DM, Trobe JD. The emerging role of magnetic resonance angiography in the management of patients with third cranial nerve palsy. Am J Ophthalmol. 1999;128(1):94–6.

    CAS  PubMed  Google Scholar 

  145. Trobe JD. Searching for brain aneurysm in third cranial nerve palsy. J Neuroophthalmol. 2009;29(3):171–3.

    PubMed  Google Scholar 

  146. Wilker SC, Rucker JC, Newman NJ, et al. Pain in ischaemic ocular motor cranial nerve palsies. Br J Ophthalmol. 2009;93(12): 1657–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  147. Cogan DG, Lincoff HA. Unilateral headache and oculomotor paralysis not caused by aneurysm. AMA Arch Ophthalmol. 1957;57(2):181–9.

    CAS  PubMed  Google Scholar 

  148. Landau K. Discovering a dys-covering lid. Surv Ophthalmol. 1997;42(1):87–91.

    CAS  PubMed  Google Scholar 

  149. Carrasco JR, Savino PJ, Bilyk JR. Primary aberrant oculomotor nerve regeneration from a posterior communicating artery aneurysm. Arch Ophthalmol. 2002;120(5):663–5.

    PubMed  Google Scholar 

  150. Varma R, Miller NR. Primary oculomotor nerve synkinesis caused by an extracavernous intradural aneurysm. Am J Ophthalmol. 1994;118(1):83–7.

    CAS  PubMed  Google Scholar 

  151. Bartleson JD, Trautmann JC, Sundt Jr TM. Minimal oculomotor nerve paresis secondary to unruptured intracranial aneurysm. Arch Neurol. 1986;43(10):1015–20.

    CAS  PubMed  Google Scholar 

  152. Payne JW, Adamkiewicz Jr J. Unilateral internal ophthalmoplegia with intracranial aneurysm. Am J Ophthalmol. 1969;68(2):349–52.

    CAS  PubMed  Google Scholar 

  153. Chaudhary N, Davagnanam I, Ansari SA, et al. Imaging of intracranial aneurysms causing isolated third cranial nerve palsy. J Neuroophthalmol. 2009;29(3):238–44.

    PubMed  Google Scholar 

  154. Lee AG, Johnson MC, Policeni BA, Smoker WR. Imaging for neuro-ophthalmic and orbital disease – a review. Clin Exp Ophthalmol. 2009;37(1):30–53.

    Google Scholar 

  155. Lee AG, Hayman LA, Brazis PW. The evaluation of isolated third nerve palsy revisited: an update on the evolving role of magnetic resonance, computed tomography, and catheter angiography. Surv Ophthalmol. 2002;47(2):137–57.

    PubMed  Google Scholar 

  156. van Rooij WJ, Sprengers ME, de Gast AN, et al. 3D rotational angiography: the new gold standard in the detection of additional intracranial aneurysms. AJNR Am J Neuroradiol. 2008;29(5): 976–9.

    PubMed  Google Scholar 

  157. Mathew MR, Teasdale E, McFadzean RM. Multidetector computed tomographic angiography in isolated third nerve palsy. Ophthalmology. 2008;115(8):1411–5.

    PubMed  Google Scholar 

  158. White PM, Wardlaw JM, Lindsay KW, et al. The non-invasive detection of intracranial aneurysms: are neuroradiologists any better than other observers? Eur Radiol. 2003;13(2):389–96.

    PubMed  Google Scholar 

  159. Loevner LA, Sonners AI, Schulman BJ, et al. Reinterpretation of cross-sectional images in patients with head and neck cancer in the setting of a multidisciplinary cancer center. AJNR Am J Neuroradiol. 2002;23(10):1622–6.

    PubMed  Google Scholar 

  160. Beard C. Ptosis. 3rd ed. St. Louis: Mosby; 1981. ix, 276 p.

    Google Scholar 

  161. Duke-Elder S. System of ophthalmology. vol V. London: Kimpton; 1963.

    Google Scholar 

  162. Pratt SG, Beyer CK, Johnson CC. The Marcus Gunn phenomenon. A review of 71 cases. Ophthalmology. 1963;91(1):27–30.

    CAS  PubMed  Google Scholar 

  163. Demirci H, Frueh BR, Nelson CC. Marcus Gunn jaw-winking synkinesis: clinical features and management. Ophthalmology. 2010;117(7):1447–52.

    PubMed  Google Scholar 

  164. Bowyer JD, Sullivan TJ. Management of Marcus Gunn jaw winking synkinesis. Ophthal Plast Reconstr Surg. 2004;20(2):92–8.

    PubMed  Google Scholar 

  165. Dillman DB, Anderson RL. Levator myectomy in synkinetic ptosis. Arch Ophthalmol. 1984;102(3):422–3.

    CAS  PubMed  Google Scholar 

  166. Spillane J, Beeson DJ, Kullmann DM. Myasthenia and related disorders of the neuromuscular junction. J Neurol Neurosurg Psychiatry. 2010;81(8):850–7.

    Google Scholar 

  167. Elrod RD, Weinberg DA. Ocular myasthenia gravis. Ophthalmol Clin North Am. 2004;17(3):275–309; v.

    PubMed  Google Scholar 

  168. Seybold ME. Myasthenia gravis. A clinical and basic science review. JAMA. 1983;250(18):2516–21.

    CAS  PubMed  Google Scholar 

  169. Vincent A, Clover L, Buckley C, et al. Evidence of underdiagnosis of myasthenia gravis in older people. J Neurol Neurosurg Psychiatry. 2003;74(8):1105–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  170. Sommer N, Sigg B, Melms A, et al. Ocular myasthenia gravis: response to long-term immunosuppressive treatment. J Neurol Neurosurg Psychiatry. 1997;62(2):156–62.

    CAS  PubMed Central  PubMed  Google Scholar 

  171. Monsul NT, Patwa HS, Knorr AM, et al. The effect of prednisone on the progression from ocular to generalized myasthenia gravis. J Neurol Sci. 2004;217(2):131–3.

    CAS  PubMed  Google Scholar 

  172. Kupersmith MJ, Latkany R, Homel P. Development of generalized disease at 2 years in patients with ocular myasthenia gravis. Arch Neurol. 2003;60(2):243–8.

    PubMed  Google Scholar 

  173. Grob D, Brunner N, Namba T, Pagala M. Lifetime course of myasthenia gravis. Muscle Nerve. 2008;37(2):141–9.

    PubMed  Google Scholar 

  174. Bever Jr CT, Aquino AV, Penn AS, et al. Prognosis of ocular myasthenia. Ann Neurol. 1983;14(5):516–9.

    PubMed  Google Scholar 

  175. Gorelick PB, Rosenberg M, Pagano RJ. Enhanced ptosis in myasthenia gravis. Arch Neurol. 1981;38(8):531.

    CAS  PubMed  Google Scholar 

  176. Gay AJ, Salmon ML, Windsor CE. Hering’s law, the levators, and their relationship in disease states. Arch Ophthalmol. 1967;77(2):157–60.

    CAS  PubMed  Google Scholar 

  177. Cogan DG. Myasthenia gravis: a review of the disease and a description of lid twitch as a characteristic sign. Arch Ophthalmol. 1965;74:217–21.

    CAS  PubMed  Google Scholar 

  178. Kubis KC, Danesh-Meyer HV, Savino PJ, Sergott RC. The ice test versus the rest test in myasthenia gravis. Ophthalmology. 2000;107(11):1995–8.

    CAS  PubMed  Google Scholar 

  179. Sethi KD, Rivner MH, Swift TR. Ice pack test for myasthenia gravis. Neurology. 1987;37(8):1383–5.

    CAS  PubMed  Google Scholar 

  180. Golnik KC, Pena R, Lee AG, Eggenberger ER. An ice test for the diagnosis of myasthenia gravis. Ophthalmology. 1999;106(7):1282–6.

    CAS  PubMed  Google Scholar 

  181. Chatzistefanou KI, Kouris T, Iliakis E, et al. The ice pack test in the differential diagnosis of myasthenic diplopia. Ophthalmology. 2009;116(11):2236–43.

    PubMed  Google Scholar 

  182. Seybold ME. The office Tensilon test for ocular myasthenia gravis. Arch Neurol. 1986;43(8):842–3.

    CAS  PubMed  Google Scholar 

  183. Barton JJ, Fouladvand M. Ocular aspects of myasthenia gravis. Semin Neurol. 2000;20(1):7–20.

    CAS  PubMed  Google Scholar 

  184. Vincent A, Newsom-Davis J. Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays. J Neurol Neurosurg Psychiatry. 1985;48(12):1246–52.

    CAS  PubMed Central  PubMed  Google Scholar 

  185. Vrolix K, Fraussen J, Molenaar PC, et al. The auto-antigen repertoire in myasthenia gravis. Autoimmunity. 2010;43:380–400.

    CAS  PubMed  Google Scholar 

  186. Drachman DB. Myasthenia gravis. N Engl J Med. 1994;330(25):1797–810.

    CAS  PubMed  Google Scholar 

  187. Benatar M, Kaminski H. Medical and surgical treatment for ocular myasthenia. Cochrane Database Syst Rev 2006(2):CD005081.

    Google Scholar 

  188. Seybold ME, Drachman DB. Gradually increasing doses of prednisone in myasthenia gravis. Reducing the hazards of treatment. N Engl J Med. 1974;290(2):81–4.

    CAS  PubMed  Google Scholar 

  189. Wong VA, Beckingsale PS, Oley CA, Sullivan TJ. Management of myogenic ptosis. Ophthalmology. 2002;109(5):1023–31.

    PubMed  Google Scholar 

  190. Demartelaere SL, Blaydon SM, Shore JW. Tarsal switch levator resection for the treatment of blepharoptosis in patients with poor eye protective mechanisms. Ophthalmology. 2006;113(12):2357–63.

    PubMed  Google Scholar 

  191. Walton KA, Buono LM. Horner syndrome. Curr Opin Ophthalmol. 2003;14(6):357–63.

    PubMed  Google Scholar 

  192. Mughal M, Longmuir R. Current pharmacologic testing for Horner syndrome. Curr Neurol Neurosci Rep. 2009;9(5):384–9.

    PubMed  Google Scholar 

  193. Jacobson DM, Berg R, Grinstead GF, Kruse JR. Duration of positive urine for cocaine metabolite after ophthalmic administration: implications for testing patients with suspected Horner syndrome using ophthalmic cocaine. Am J Ophthalmol. 2001;131(6):742–7.

    CAS  PubMed  Google Scholar 

  194. Kawasaki A, Borruat FX. False negative apraclonidine test in two patients with Horner syndrome. Klin Monbl Augenheilkd. 2008;225(5):520–2.

    CAS  PubMed  Google Scholar 

  195. Dewan MA, Harrison AR, Lee MS. False-negative apraclonidine testing in acute Horner syndrome. Can J Ophthalmol. 2009;44(1):109–10.

    PubMed  Google Scholar 

  196. Almog Y, Gepstein R, Kesler A. Diagnostic value of imaging in horner syndrome in adults. J Neuroophthalmol. 2010;30(1):7–11.

    PubMed  Google Scholar 

  197. Thakker MM, Huang J, Possin DE, et al. Human orbital sympathetic nerve pathways. Ophthal Plast Reconstr Surg. 2008;24(5):360–6.

    PubMed  Google Scholar 

  198. Demetriades AM, Miller NR, Garibaldi DC. Bilateral internal carotid artery dissection presenting as isolated unilateral Horner syndrome. Ophthal Plast Reconstr Surg. 2009;25(6):485–6.

    PubMed  Google Scholar 

  199. Kerty E. The ophthalmology of internal carotid artery dissection. Acta Ophthalmol Scand. 1999;77(4):418–21.

    CAS  PubMed  Google Scholar 

  200. Rigamonti A, Iurlaro S, Reganati P, et al. Cluster headache and internal carotid artery dissection: two cases and review of the literature. Headache. 2008;48(3):467–70.

    PubMed  Google Scholar 

  201. Biousse V, Touboul PJ, D’Anglejan-Chatillon J, et al. Ophthalmologic manifestations of internal carotid artery dissection. Am J Ophthalmol. 1998;126(4):565–77.

    CAS  PubMed  Google Scholar 

  202. Reede DL, Garcon E, Smoker WR, Kardon R. Horner’s syndrome: clinical and radiographic evaluation. Neuroimaging Clin N Am. 2008;18(2):369–85, xi.

    PubMed  Google Scholar 

  203. Menon R, Kerry S, Norris JW, Markus HS. Treatment of cervical artery dissection: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2008;79(10):1122–7.

    CAS  PubMed  Google Scholar 

  204. Smith SJ, Diehl N, Leavitt JA, Mohney BG. Incidence of pediatric Horner syndrome and the risk of neuroblastoma: a population-based study. Arch Ophthalmol. 2010;128(3):324–9.

    PubMed Central  PubMed  Google Scholar 

  205. Jeffery AR, Ellis FJ, Repka MX, Buncic JR. Pediatric Horner syndrome. J AAPOS. 1998;2(3):159–67.

    CAS  PubMed  Google Scholar 

  206. Mahoney NR, Liu GT, Menacker SJ, et al. Pediatric horner syndrome: etiologies and roles of imaging and urine studies to detect neuroblastoma and other responsible mass lesions. Am J Ophthalmol. 2006;142(4):651–9.

    PubMed  Google Scholar 

  207. Pirouzian A, Holz HA, Ip KC, Sudesh R. Acquired infantile Horner syndrome and spontaneous internal carotid artery dissection: a case report and review of literature. J AAPOS. 2010;14(2):172–4.

    PubMed  Google Scholar 

  208. Sobel J. Botulism. Clin Infect Dis. 2005;41(8):1167–73.

    CAS  PubMed  Google Scholar 

  209. Caya JG. Clostridium botulinum and the ophthalmologist: a review of botulism, including biological warfare ramifications of botulinum toxin. Surv Ophthalmol. 2001;46(1):25–34.

    CAS  PubMed  Google Scholar 

  210. Capobianco DJ, Dodick DW. Diagnosis and treatment of cluster headache. Semin Neurol. 2006;26(2):242–59.

    PubMed  Google Scholar 

  211. Silberstein SD, Lipton RB, Dodick D, Wolff HG (eds). Wolff’s headache and other head pain. 8th ed. Oxford/New York: Oxford University Press, 2008; xx, 844 p

    Google Scholar 

  212. DaSilva AF, Goadsby PJ, Borsook D. Cluster headache: a review of neuroimaging findings. Curr Pain Headache Rep. 2007;11(2):131–6.

    PubMed  Google Scholar 

  213. Pinessi L, Rainero I, Rivoiro C, et al. Genetics of cluster headache: an update. J Headache Pain. 2005;6(4):234–6.

    PubMed Central  PubMed  Google Scholar 

  214. Schurks M, Diener HC. Cluster headache and lifestyle habits. Curr Pain Headache Rep. 2008;12(2):115–21.

    PubMed  Google Scholar 

  215. May A, Leone M, Afra J, et al. EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. Eur J Neurol. 2006;13(10):1066–77.

    CAS  PubMed  Google Scholar 

  216. Hansen SL, Borelli-Moller L, Strange P, et al. Ophthalmoplegic migraine: diagnostic criteria, incidence of hospitalization and possible etiology. Acta Neurol Scand. 1990;81(1):54–60.

    CAS  PubMed  Google Scholar 

  217. Levin M, Ward TN. Ophthalmoplegic migraine. Curr Pain Headache Rep. 2004;8(4):306–9.

    PubMed  Google Scholar 

  218. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988;8(Suppl 7):1–96.

    Google Scholar 

  219. Bek S, Genc G, Demirkaya S, et al. Ophthalmoplegic migraine. Neurologist. 2009;15(3):147–9.

    PubMed  Google Scholar 

  220. Carlow TJ. Oculomotor ophthalmoplegic migraine: is it really migraine? J Neuroophthalmol. 2002;22(3):215–21.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Oculoplastic & Orbital Surgery Service, Wills Eye Institute, Jefferson Medical College, Philadelphia, PA, USA

    Ann P. Murchison M.D., M.P.H. (Assistant Professor of Ophthalmology)

  2. Oculoplastic and Orbital Surgery Service, Wills Eye Institute, Jefferson Medical College, Philadelphia, PA, USA

    Jurij R. Bilyk M.D. (Associate Professor of Ophthalmology)

  3. Department of Ophthalmology, University of California, San Diego, La Jolla, CA, USA

    Peter J. Savino M.D.

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  1. Ann P. Murchison M.D., M.P.H.
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  3. Peter J. Savino M.D.
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Correspondence to Ann P. Murchison M.D., M.P.H. .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Associate Professor of Ophthalmology Wayne State University School of Med, Detroit, Michigan, USA

    Evan H. Black

  2. Oakland University William Beaumont, Clinical Professor of Ophthalmology Director, Oculoplastic Surgery, Southfield, Michigan, USA

    Frank A. Nesi

  3. Department of Ophthalmology, University of Central Florida, Orlando, USA

    Christopher J. Calvano

  4. William Beaumont School of Medicine, Clinical Professor of Ophthalmology Co-Director, Oculoplastic Surgery, Detroit, Michigan, USA

    Geoffrey J. Gladstone

  5. Former Chief of Ophthalmology, Emeritus Clinical Prof of Ophthalmology Case Western Reserve University, South Euclid, USA

    Mark R. Levine

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Murchison, A.P., Bilyk, J.R., Savino, P.J. (2012). Ptosis in Neurologic Disease. In: Black, E., Nesi, F., Calvano, C., Gladstone, G., Levine, M. (eds) Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0971-7_23

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