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Notch Signaling and Brain Tumors

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Notch Signaling in Embryology and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 727))

Abstract

Human brain tumors are a heterogenous group of neoplasms occurring inside the cranium and the central spinal cord. In adults and children, astrocytic glioma and medulloblastoma are the most common subtypes of primary brain tumors. These tumor types are thought to arise from cells in which Notch signaling plays a fundamental role during development. Recent findings have shown that Notch signaling is dysregulated and contributes to the malignant potential of these tumors. Growing evidence point towards an important role for cancer stem cells in the initiation and maintenance of glioma and medulloblastoma. In this chapter we will cover the present findings of Notch signaling in human glioma and medulloblastoma and try to create an overall picture of its relevance in the pathogenesis of these tumors.

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Authors and Affiliations

  1. Department of Radiation Biology, The Finsen Center, Copenhagen University Hospital, Copenhagen, Denmark

    Marie-Thérése Stockhausen, Karina Kristoffersen & Hans Skovgaard Poulsen

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  1. Marie-Thérése Stockhausen
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  2. Karina Kristoffersen
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  3. Hans Skovgaard Poulsen
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Correspondence to Marie-Thérése Stockhausen .

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Editors and Affiliations

  1. Department of Dermatology, The Saarland University Hospital, Homburg, Germany

    Jörg Reichrath

  2. Department of Internal Medicine I, The Saarland University Hospital, Homburg, Germany

    Sandra Reichrath

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Stockhausen, MT., Kristoffersen, K., Poulsen, H.S. (2012). Notch Signaling and Brain Tumors. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 727. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0899-4_22

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