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Notch Signaling and the Developing Hair Follicle

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Notch Signaling in Embryology and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 727))

Abstract

Notch function in the hair follicle has been mainly studied by use of transgenic mice carrying either loss or gain of function mutations in various members of the pathway. These studies revealed that whereas embryonic development of the hair follicle can be achieved without Notch, its postnatal development requires an intact Notch signaling in the hair bulb and the outer root sheath. Among the many roles played by Notch in the hair follicle, two can be highlighted: in the bulge, Notch controls a cell fate switch in hair follicle stem cells or their progenitors, preventing them from adopting an epidermal fate. In the hair bulb, Notch controls cell differentiation, ensuring the proper development of every layer of the hair shaft and inner root sheath. Notch function in the hair follicle is both cell autonomous and cell non autonomous and involves intercellular communication between adjacent layers.

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Author information

Authors and Affiliations

  1. INRA, UMR955 Génétique Fonctionnelle et Médicale, Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France

    Geneviève Aubin-Houzelstein

  2. CNRS URA2578 Département de Biologie du Développement, Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Paris, France

    Geneviève Aubin-Houzelstein

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  1. Geneviève Aubin-Houzelstein
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Editors and Affiliations

  1. Department of Dermatology, The Saarland University Hospital, Homburg, Germany

    Jörg Reichrath

  2. Department of Internal Medicine I, The Saarland University Hospital, Homburg, Germany

    Sandra Reichrath

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© 2012 Landes Bioscience and Springer Science+Business Media

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Aubin-Houzelstein, G. (2012). Notch Signaling and the Developing Hair Follicle. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 727. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0899-4_11

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