Site Specific Controlled Release for Cardiovascular Disease: Translational Directions

  • Ilia Fishbein
  • Michael Chorny
  • Ivan S. Alferiev
  • Robert J. Levy
Part of the Advances in Delivery Science and Technology book series (ADST)


Cardiovascular diseases remain the leading cause of mortality worldwide. Despite tremendous progress in prophylaxis, diagnostics, and pharmacology of cardiovascular disorders, a number of disease states cannot be successfully treated even with the most sophisticated therapeutics. A significant part of the problem is a lack of adequate systems for the focal delivery of therapeutic agents to disease sites in the heart and blood vessels. Over the last 30 years, basic and translational research on the interface of pharmacology, pharmaceutics, physiology, biomaterials, and nanotechnology have made possible the emergence of clinical grade site specific controlled release devices, which have become standards of care in cardiovascular medicine. There are multiple advantages of controlled release systems for localized site specific treatments, including increased efficacy, reduced side effects, and favorable tissue scaffolding properties.


Endothelial Progenitor Cell Drug Elute Stents Bare Metal Stents Late Stent Thrombosis Control Release System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors thank Susan Kerns, the Children’s Hospital of Philadelphia, for her assistance in reviewing the manuscript and preparing materials for submission. The research at the Children’s Hospital of Philadelphia reported in this chapter was supported in part by a grant from the National Institutes of Health (HL72108), Scientist Development Grants from the American Heart Association, a QED-Grant from the University Science Center of Philadelphia, and The William J. Rashkind Endowment of The Children’s Hospital of Philadelphia.


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Copyright information

© Springer US 2012

Authors and Affiliations

  • Ilia Fishbein
    • 1
  • Michael Chorny
    • 1
  • Ivan S. Alferiev
    • 1
  • Robert J. Levy
    • 1
  1. 1.Abramson Research CenterThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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