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The ACL Handbook pp 73–89Cite as

The Role of Inflammation and Blood Cells in Wound Healing

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Abstract

Successful wound healing is a complex and elegant process, involving multiple cell types, hundreds of growth factors, and the time-dependent expression of thousands of genes. A basic understanding of this process will allow us to compare successful wound healing with the ineffective wound healing seen even after suture repair of the ACL. Comparing the two processes will allow us to determine where the problems lie in ACL healing so that we can come up with novel ways to improve healing. A review of the major phases of wound healing and key cell types involved in each phase is presented in this chapter.

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Acknowledgement

Research reported in this chapter was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Numbers RO1-AR052772 and RO1-AR054099. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Author information

Authors and Affiliations

  1. Department of Orthopedic Surgery, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA

    Linda H. Chao BA

  2. The Warren Alpert Medical School of Brown University, Providence, RI, USA

    Linda H. Chao BA

  3. Department of Orthopedic Surgery, Division of Sports Medicine, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA

    Martha M. Murray MD

Authors
  1. Linda H. Chao BA
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  2. Martha M. Murray MD
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Correspondence to Martha M. Murray MD .

Editor information

Editors and Affiliations

  1. Boston Children's Hospital, Harvard Medical School, Department of Orthopedic Surgery, Longwood Avenue 300, Boston, 02115, Massachusetts, USA

    Martha M. Murray

  2. Boston Children's Hospital, Harvard Medical School, Department of Orthopedic Surgery, Longwood Avenue 300, Boston, 02115, Massachusetts, USA

    Patrick Vavken

  3. Brown University, Rhode Island Hospital, Warren Alpert Medical School, Hoppin Street 1, Providence, 02903, Rhode Island, USA

    Braden Fleming

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Chao, L.H., Murray, M.M. (2013). The Role of Inflammation and Blood Cells in Wound Healing. In: Murray, M., Vavken, P., Fleming, B. (eds) The ACL Handbook. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0760-7_6

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  • DOI: https://doi.org/10.1007/978-1-4614-0760-7_6

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-0759-1

  • Online ISBN: 978-1-4614-0760-7

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