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In Vivo Models of ACL Injury (Central Defect, Porcine, Ovine, Canine)

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Abstract

Animal models are an indispensable tool for developing and testing new potential treatments of acute injuries and chronic diseases of all parts of the body, including the knee joint. However, when using animal models to study a particular disease or problem, careful attention to the similarities and differences of those models to the human condition is critical. With the understandings of the translational strengths and weaknesses of each model, the investigator can choose the model with the optimal human representation for the specific question being asked.

For ACL injury, there are several large animal models that have been reported and are still in use. Among these are the mouse, rabbit, dog, sheep, goat, and the pig. The following chapter will give insight into the different animal models for ACL injury, will detail the similarities and differences with the human condition, and will review what has been learned from studies in these animals to date for ACL injury and treatment.

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Acknowledgements

Research reported in this chapter was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Numbers RO1-AR054099 and RO1-AR056834. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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  1. Department of Orthopedic Surgery, Division of Sports Medicine, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA

    Benedikt Lorenz Proffen MD & Martha M. Murray MD

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  1. Benedikt Lorenz Proffen MD
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  2. Martha M. Murray MD
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Correspondence to Benedikt Lorenz Proffen MD .

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Editors and Affiliations

  1. Boston Children's Hospital, Harvard Medical School, Department of Orthopedic Surgery, Longwood Avenue 300, Boston, 02115, Massachusetts, USA

    Martha M. Murray

  2. Boston Children's Hospital, Harvard Medical School, Department of Orthopedic Surgery, Longwood Avenue 300, Boston, 02115, Massachusetts, USA

    Patrick Vavken

  3. Brown University, Rhode Island Hospital, Warren Alpert Medical School, Hoppin Street 1, Providence, 02903, Rhode Island, USA

    Braden Fleming

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Proffen, B.L., Murray, M.M. (2013). In Vivo Models of ACL Injury (Central Defect, Porcine, Ovine, Canine). In: Murray, M., Vavken, P., Fleming, B. (eds) The ACL Handbook. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0760-7_11

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