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PRC Estimation with Varying Width Intervals

  • Daniel G. Polhamus
  • Charles J. Wilson
  • Carlos A. Paladini
Chapter
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI, volume 6)

Abstract

The definition of the infinitesimal phase-resetting curve implies that the period of oscillation is known and constant for all values of the perturbation phase. Experimental estimation of the infinitesimal phase-resetting curve in neurons requires estimation of the unperturbed period of oscillation and the changes in the period in response to perturbations along the phase. Action potentials provide well-defined, yet stochastic endpoints of the cycle of oscillation. Experimental estimation of the phase-resetting curve is substantially complicated as a result. Here, we discuss a common problem with experimental PRC estimation caused by using the mean interspike interval (ISI) to describe the resting period. We propose a solution through truncated estimators of the firing period, conditioned upon observed phase: i.e., an estimate of the period given that we have experienced up to phase τ.

Keywords

Mean Square Error Subthalamic Nucleus Periodic Estimate Conditional Sample Phase Reset 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Daniel G. Polhamus
    • 1
  • Charles J. Wilson
    • 1
  • Carlos A. Paladini
    • 1
  1. 1.UTSA Neurosciences InstituteUniversity of Texas at San AntonioSan AntonioUSA

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