PRC Estimation with Varying Width Intervals

  • Daniel G. Polhamus
  • Charles J. Wilson
  • Carlos A. Paladini
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI, volume 6)


The definition of the infinitesimal phase-resetting curve implies that the period of oscillation is known and constant for all values of the perturbation phase. Experimental estimation of the infinitesimal phase-resetting curve in neurons requires estimation of the unperturbed period of oscillation and the changes in the period in response to perturbations along the phase. Action potentials provide well-defined, yet stochastic endpoints of the cycle of oscillation. Experimental estimation of the phase-resetting curve is substantially complicated as a result. Here, we discuss a common problem with experimental PRC estimation caused by using the mean interspike interval (ISI) to describe the resting period. We propose a solution through truncated estimators of the firing period, conditioned upon observed phase: i.e., an estimate of the period given that we have experienced up to phase τ.


Mean Square Error Subthalamic Nucleus Periodic Estimate Conditional Sample Phase Reset 
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Daniel G. Polhamus
    • 1
  • Charles J. Wilson
    • 1
  • Carlos A. Paladini
    • 1
  1. 1.UTSA Neurosciences InstituteUniversity of Texas at San AntonioSan AntonioUSA

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