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Aerospace Toxicology Overview: Aerial Application and Cabin Air Quality

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Book cover Reviews of Environmental Contamination and Toxicology

Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 214))

Abstract

The environment extending above and beyond the surface of the planet Earth is referred to as aerospace (Blashfield and Johnson 1969). This word also symbolizes the joint fields of aeronautics and astronautics. The former is the art and science of flight through the atmosphere (Blashfield and Johnson 1969) and the latter is the art and science of space flight (Blashfield and Johnson 1968a). Another term frequently and interchangeably used with aerospace and aeronautics is aviation, which is defined as the art and science of operating powered aircraft (Chaturvedi 2010a, b; The Encyclopedia Americana 1989).

This document is disseminated under the sponsorship of the US Department of Transportation in the interest of information exchange. The US Government assumes no liability for the contents or use thereof. The work included in this paper is performed by a US employee as part of his official duty. Under the official duty, this paper has also been produced as a section of an internal technical report of the Office of Aerospace Medicine, Federal Aviation Administration, US Department of Transportation (DOT/FAA/AM-09/8) (Chaturvedi 2009). A part of this study was presented at the 80th Annual Scientific Meeting of the Aerospace Medical Association held during 3–7 May 2009 in Los Angeles, CA.

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References

  • Abeyratne R (2002) Forensic aspects of the aerotoxic syndrome. Med Law 21:179–199.

    Google Scholar 

  • AVOXimeter (2001) AVOXimeter 4000 Manual. A-VOX Systems, Inc., San Antonio, TX.

    Google Scholar 

  • Backman H, Haghighat F (2000) Air quality and ocular discomfort aboard commercial aircraft. Optometry 71:653–656.

    Google Scholar 

  • Bergau L (1999) [Radiation exposure and air quality aboard commercial airplanes]. Z Arztl Fortbild Qualitatssich 93:491–494.

    Google Scholar 

  • Blanke RV (1976a) Analysis of drugs and toxic substances. In: Tietz NW (ed) Fundamentals of Clinical Chemistry, 2nd Ed. W.B. Saunders Co., Philadelphia, PA pp 1105–1109.

    Google Scholar 

  • Blanke RV (1976b) Analysis of drugs and toxic substances. In: Tietz NW (ed) Fundamentals of Clinical Chemistry, 2nd Ed. W.B. Saunders Co., Philadelphia, PA pp 1116–1118.

    Google Scholar 

  • Blashfield JF, Johnson RJ (1968a) Above and Beyond: The Encyclopedia of Aviation and Space Sciences. New Horizons Publishers, Inc., Chicago, IL p 212.

    Google Scholar 

  • Blashfield JF, Johnson RJ (1968b) Above and Beyond: The Encyclopedia of Aviation and Space Sciences. New Horizons Publishers, Inc., Chicago, IL p 292.

    Google Scholar 

  • Blashfield JF, Johnson RJ (1969) Above and Beyond: The Encyclopedia of Aviation and Space Sciences. New Horizons Publishers, Inc., Chicago, IL p 26.

    Google Scholar 

  • Brown TP, Shuker LK, Rushton L, Warren F, Stevens J (2001) The possible effects on health, comfort and safety of aircraft cabin environments. J R Soc Health 121:177–184.

    Google Scholar 

  • Brundrett G (2001) Comfort and health in commercial aircraft: a literature review. J R Soc Health 121:29–37.

    Google Scholar 

  • CAA (2004) Safety Regulation Group: cabin air quality, Report No. CAA Paper 2004/04 (2004 Feb). Civil Aviation Authority (CAA), West Sussex, UK.

    Google Scholar 

  • Canfield DV, Smith M, Ritter RM, Chaturvedi AK (1999) Preparation of carboxyhemoglobin standards and calculation of spectrophotometric quantitation constants. J Forensic Sci 44:409–412.

    Google Scholar 

  • Canfield DV, Smith MD, Ritter RM, Chaturvedi AK (1998) Preparation of carboxyhemoglobin standards and calculation of spectrophotometric quantitation constants, Report No. DOT/FAA/AM-98/21 (1998 Aug). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Cardeal ZL, Pradeau D, Hamon M, Abdoulaye I, Pailler FM, Lejeune B (1993) New calibration method for gas chromatographic assay of carbon monoxide in blood. J Anal Toxicol 17:193–195.

    Google Scholar 

  • Case University (2008) Aerospace medicine. Retrieved 23 April 2008 from http://www.case.edu/med/epidbio/mphp439/Dictionary.htm.

  • Chaturvedi AK (1993a) Biochemical and toxicological studies on the mixtures of three commonly-used herbicides in mice. Arch Environ Contam Toxicol 24:449–454.

    Google Scholar 

  • Chaturvedi AK (1993b) Toxicological evaluation of mixtures of ten widely used pesticides. J Appl Toxicol 13:183–188.

    Google Scholar 

  • Chaturvedi AK (1995) Smoke!, Report No. AM-400-95/1. U.S. Department of Transportation, Federal Aviation Administration, Civil Aerospace Medical Institute, Aerospace Medical Education Division, Oklahoma City, OK.

    Google Scholar 

  • Chaturvedi AK (2009) Aerospace toxicology: an overview, Report No. DOT/FAA/AM-09/8 (2009 Apr). U.S. Department of Transportation, Federal Aviation Administration, Office of Aerospace Medicine, Washington, DC.

    Google Scholar 

  • Chaturvedi AK (2010a) Aviation combustion toxicology: an overview. J Anal Toxicol 34:1–16.

    Google Scholar 

  • Chaturvedi AK (2010b) Postmortem aviation forensic toxicology: an overview. J Anal Toxicol 34:169–176.

    Google Scholar 

  • Chaturvedi AK, Kuntz DJ, Rao NGS (1991) Metabolic aspects of the toxicology of mixtures of parathion, toxaphene and/or 2,4-D in mice. J Appl Toxicol 11:245–251.

    Google Scholar 

  • Chaturvedi AK, Rao NGS, McCoy FE (1983) A multi-chemical death involving caffeine, nicotine and malathion. Forensic Sci Int 23:265–275.

    Google Scholar 

  • Chaturvedi AK, Sanders DC (1995) Aircraft fires, smoke toxicity, and survival: an overview, Report No. DOT/FAA/AM-95/8 (1995 Feb). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Chaturvedi AK, Sanders DC (1996) Aircraft fires, smoke toxicity, and survival. Aviat Space Environ Med 67:275–278.

    Google Scholar 

  • Chaturvedi AK, Singh G, Rao NGS, Parker TM (1989) Toxicological evaluation of a poisoning attributed to ingestion of malathion insect spray and correlation with in vitro inhibition of cholinesterases. Hum Toxicol 8:11–18.

    Google Scholar 

  • Chaturvedi AK, Smith DR, Canfield DV (2001) Blood carbon monoxide and hydrogen cyanide concentrations in the fatalities of fire and non-fire associated civil aviation accidents, 1991–1998. Forensic Sci Int 121:183–188.

    Google Scholar 

  • Clark G (1966a) Problems in aerial application: a comparison of the acute effects of endrin and carbon tetrachloride on the livers of rats and of the residual effects one month after poisoning, Report No. FAA-AM-66-34 (1966 Jul). U.S. Department of Transportation, Federal Aviation Agency, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Clark G (1966b) Problems in aerial application: a comparison of the effects of dieldrin poisoning in cold-adapted and room-temperature mammals, Report No. FAA-AM-66-5 (1966 Apr). U.S. Department of Transportation, Federal Aviation Agency, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • CO-Oximeter (1978) Operator’s manual IL282 CO-Oximeter. Instrumentation Laboratory, Inc., Lexington, MA.

    Google Scholar 

  • Crane CR, Sanders DC, Abbot JK (1970a) A comparison of three serum cholinesterase methods, Report No. FAA-AM-70-13 (1970 Aug). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Crane CR, Sanders DC, Abbot JK (1970b) Studies on the storage stability of human blood cholinesterases: I, Report No. FAA-AM-70-4 (1970 Jan). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Crane CR, Sanders DC, Abbot JK (1972) A comparison of serum cholinesterase methods: II, Report No. FAA-AM-72-12 (1972 Mar). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Crane CR, Sanders DC, Endecott BR, Abbott JK (1983) Inhalation toxicology: III. evaluation of thermal degradation products from aircraft and automobile engine oils, aircraft hydraulic fluid, and mineral oil, Report No. FAA-AM-83-12 (1983 Apr). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Cullen SA, Hill IR (2006) Aviation pathology and toxicology. In: Rainford DJ, Gradwell DP (eds) Ernsting’s Aviation Medicine, 4th Ed. Hodder Arnold, London, UK pp 517–532.

    Google Scholar 

  • Daugherty JW, Lacey DE, Korty P (1962) Problems in aerial application: I. some biochemical effects of lindane and dieldrin on vertebrates, Report No. FAA-AM-62-10 (1962 May). U.S. Department of Transportation, Federal Aviation Agency, Civil Aeromedical Research Institute, Oklahoma City, OK.

    Google Scholar 

  • Daugherty JW, Lacey DE, Korty P (1963) Problems in aerial application: II. effects of chlorinated hydrocarbons on substrate-linked phosphorylation, Report No. FAA-AM-63-4 (1963 Mar). U.S. Department of Transportation, Federal Aviation Agency, Civil Aeromedical Research Institute, Oklahoma City, OK.

    Google Scholar 

  • Dechow M, Sohn H, Steinhanses J (1997) Concentrations of selected contaminants in cabin air of airbus aircrafts. Chemosphere 35:21–31.

    Google Scholar 

  • DeHart RL (2003) Health issues of air travel. Annu Rev Public Health 24:133–151.

    Google Scholar 

  • Dille JR, Mohler SR (1968) Drug and toxic hazards in general aviation, Report No. FAA-AM-68-16 (1968 Sep). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Dille JR, Morris EW (1966) Human factors in general aviation accidents, Report No. FAA-AM-66-27 (1966 Jul). U.S. Department of Transportation, Federal Aviation Agency, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Dille JR, Morris EW (1967) Human factors in general aviation accidents. Aerosp Med 38:1063–1066.

    Google Scholar 

  • Dille JR, Smith PW (1963) Central nervous system effects of chronic exposure to organophosphate insecticides, Report No. FAA-AM-63-24 (1963 Oct). U.S. Department of Transportation, Federal Aviation Agency, Civil Aeromedical Research Institute, Oklahoma City, OK.

    Google Scholar 

  • Dille JR, Smith PW (1964) Central nervous system effects of chronic exposure to organophosphate insecticides. Aerosp Med 35:474–478.

    Google Scholar 

  • Douglas TA (1962) The determination of carbon monoxide in blood. Ann Occup Hyg 5:211–216.

    Google Scholar 

  • Dunn WA, Siek TJ (1990) A rapid, sensitive, and specific screening technique for the determination of cyanide. J Anal Toxicol 14:256.

    Google Scholar 

  • Eaton DL, Klaassen CD (1996) Principles of toxicology. In: Klaassen CD, Amdur MO, Doull J (eds) Casarett & Doull’s Toxicology: The Basic Science of Poisons, 5th Ed. McGraw-Hill, New York, NY pp 13–33.

    Google Scholar 

  • Ecobichon DJ (1990) Chemical management of forest pest epidemics: a case study. Biomed Environ Sci 3:217–239.

    Google Scholar 

  • Ecobichon DJ (1996) Toxic effects of pesticides. In: Klaassen CD, Amdur MO, Doull J (eds) Casarett & Doull’s Toxicology: The Basic Science of Poisons, 5th Ed. McGraw-Hill, New York, NY pp 643–689.

    Google Scholar 

  • Emerson TE, Jr., Brake CM, Hinshaw LB (1963) Mechanism of action of the insecticide endrin, Report No. FAA-AM-63-16 (1963 Aug). U.S. Department of Transportation, Federal Aviation Agency, Civil Aeromedical Research Institute, Oklahoma City, OK.

    Google Scholar 

  • Endecott BR, Sanders DC, Chaturvedi AK (1996) Simultaneous gas chromatographic determination of four toxic gases generally present in combustion atmospheres. J Anal Toxicol 20:189–194.

    Google Scholar 

  • Feldstein M, Klendshoj NC (1957) The determination of volatile substances by microdiffusion analysis. J Forensic Sci 2:39–58.

    Google Scholar 

  • Felscher D, Wulfmeyer M (1998) A new specific method to detect cyanide in body fluids, especially whole blood, by fluorimetry. J Anal Toxicol 22:363–366.

    Google Scholar 

  • Fenner OH (1975) Chemical and environmental properties of plastics and elastomers (Chapter 4). In: Harper CA (ed) Handbook of Plastics and Elastomers. McGraw-Hill Book Company, New York, NY pp 4-1–81.

    Google Scholar 

  • Fowler PR, McKenzie JM (1967) Problems in aerial application: detection of mild poisoning by organophosphorus pesticides using an automated method for cholinesterase activity, Report No. FAA-AM-67-5 (1967 Apr). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Freireich A, Landau D, Dubowski KM, Jain NC (1975) Carbon Monoxide: type B procedure. In: Sunshine I (ed) Methodology for Analytical Toxicology. CRC Press, Inc., Boca Raton, FL pp 67–69.

    Google Scholar 

  • Fulton HB, Jr. (1985) A pilot’s guide to cabin air quality and fire safety. N Y State J Med 85:384–388.

    Google Scholar 

  • Gallo MA (1996) History and scope of toxicology. In: Klaassen CD, Amdur MO, Doull J (eds) Casarett & Doull’s Toxicology: The Basic Science of Poisons, 5th Ed. McGraw-Hill, New York, NY pp 3–11.

    Google Scholar 

  • Ginestet A, Pugnet D, Rowley J, Bull K, Yeomans H (2005) Development of a new photocatalytic oxidation air filter for aircraft cabin. Indoor Air 15:326–334.

    Google Scholar 

  • Gossel TA, Bricker JD (1994a) Principles of Clinical Toxicology, 3rd Ed. Raven Press, New York, NY pp 147–178.

    Google Scholar 

  • Gossel TA, Bricker JD (1994b) Principles of Clinical Toxicology, 3rd Ed. Raven Press, New York, NY pp 109–134.

    Google Scholar 

  • Griffin BR (1979) A sensitive method for the routine determination of carbon monoxide in blood using flame ionization gas chromatography. J Anal Toxicol 3:102–104.

    Google Scholar 

  • Guilbault GG, Kramer DN (1966) Ultra sensitive, specific method for cyanide using p-nitrobenzaldehyde and o-dinitrobenzene. Anal Chem 38:834–836.

    Google Scholar 

  • Haditsch M (2002) [Flying fitness of patients with infections]. Wien Med Wochenschr 152:469–472.

    Google Scholar 

  • Harding R (1994) Cabin air quality in aircraft. Bmj 308:427–428.

    Google Scholar 

  • Harper CA (1975) Fundamentals of plastics and elastomers (Chapter 1). In: Harper CA (ed) Handbook of Plastics and Elastomers. McGraw-Hill Book Company, New York, NY pp 1-1–121.

    Google Scholar 

  • Hetrick SM, Gould WD, Christensen DE (2000) Inflight cabin ozone aboard long duration C-5 airlift missions: a historical issue revisited. Aviat Space Environ Med 71:408–414.

    Google Scholar 

  • Hinshaw LB, Emerson TE, Jr., Rieger JA, Jr., Stavinoha WB, Solomon LA, Fiorica V, Reins DA, Holmes DD (1966) Problems in aerial application: I.-V., Report No. FAA-AM-66-11 (1966 Jun). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Hocking MB (1998) Indoor air quality: recommendations relevant to aircraft passenger cabins. Am Ind Hyg Assoc J 59:446–454.

    Google Scholar 

  • Hocking MB (2000) Passenger aircraft cabin air quality: trends, effects, societal costs, proposals. Chemosphere 41:603–615.

    Google Scholar 

  • Hocking MB (2002) Trends in cabin air quality of commercial aircraft: industry and passenger perspectives. Rev Environ Health 17:1–49.

    Google Scholar 

  • ISO International Standard (2008) Analysis of blood for asphyxiant toxicants—carbon monoxide and hydrogen cyanide, Report No. First Edition; ISO 27368:2008 (E) (15 Aug 2008). International Organization for Standardization (ISO), Geneva, Switzerland.

    Google Scholar 

  • Kuntz DJ, Rao NGS, Berg IE, Khattree R, Chaturvedi AK (1990) Toxicity of mixtures of parathion, toxaphene and/or 2,4-D in mice. J Appl Toxicol 10:257–266.

    Google Scholar 

  • Lacefield DJ, Roberts PA, Blossom CW (1975) Toxicological findings in fatal civil aviation accidents, fiscal years 1968–1974. Aviat Space Environ Med 46:1030–1032.

    Google Scholar 

  • Lacefield DJ, Roberts PA, Blossom CW (1978) Agricultural aviation versus other general aviation: toxicological findings in fatal accidents, Report No. FAA-AM-78-31. U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Landrock AH (1983) Handbook of Plastics Flammability and Combustion Toxicology: Principles, Materials, Testing, Safety, and Smoke Inhalation Effects. Noyes Publications, Park Ridge, NJ pp 18–22.

    Google Scholar 

  • Lauwerys RR (1996) Occupational toxicology. In: Klaassen CD, Amdur MO, Doull J (eds) Casarett & Doull’s Toxicology: The Basic Science of Poisons, 5th Ed. McGraw-Hill, New York, NY pp 987–1009.

    Google Scholar 

  • Leder K, Newman D (2005) Respiratory infections during air travel. Intern Med J 35:50–55.

    Google Scholar 

  • Lewis MF, Mertens HW, Jo Ann Steen BA (1972) Behavioral changes from chronic exposure to pesticides used in aerial application: effects of phosdrin on the performance of monkeys and pigeons on variable interval reinforcement schedules, Report No. FAA-AM-72-29 (1972 Aug). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Lewis RJ, Johnson RD, Canfield DV (2004) An accurate method for the determination of carboxyhemoglobin in postmortem blood using GC-TCD. J Anal Toxicol 28:59–62.

    Google Scholar 

  • Lindgren T, Norback D (2002) Cabin air quality: indoor pollutants and climate during intercontinental flights with and without tobacco smoking. Indoor Air 12:263–272.

    Google Scholar 

  • Lindgren T, Norback D (2005) Health and perception of cabin air quality among Swedish commercial airline crew. Indoor Air 15 Suppl 10:65–72.

    Google Scholar 

  • Lindgren T, Norback D, Andersson K, Dammstrom BG (2000) Cabin environment and perception of cabin air quality among commercial aircrew. Aviat Space Environ Med 71:774–782.

    Google Scholar 

  • Lindgren T, Norback D, Wieslander G (2007) Perception of cabin air quality in airline crew related to air humidification, on intercontinental flights. Indoor Air 17:204–210.

    Google Scholar 

  • Loomis TA (1978) Essentials of Toxicology, 3rd Ed. Lea & Febiger, Philadelphia, PA pp 1–12.

    Google Scholar 

  • McAuley F, Reive DS (1983) Rapid quantitation of cyanide in blood by gas chromatography. J Anal Toxicol 7:213–215.

    Google Scholar 

  • Meyer E (1977) Chemistry of Hazardous Materials. Prentice-Hall, Inc., Englewood Cliffs, NJ pp 78–99.

    Google Scholar 

  • Mohler SR, Harper CR (1966) Protecting the AG pilot, Report No. FAA-AM-66-30 (1966 Sep). U.S. Department of Transportation, Federal Aviation Agency, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Nagda NL, Hodgson M (2001) Low relative humidity and aircraft cabin air quality. Indoor Air 11:200–214.

    Google Scholar 

  • Nagda NL, Koontz MD (2003) Review of studies on flight attendant health and comfort in airliner cabins. Aviat Space Environ Med 74:101–109.

    Google Scholar 

  • Nagda NL, Rector HE (2003) A critical review of reported air concentrations of organic compounds in aircraft cabins. Indoor Air 13:292–301.

    Google Scholar 

  • National Library of Medicine (2008) Aerospace medicine. Retrieved 23 April 2008 from http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh.

  • Nicholson AN, Cummin AR, Giangrande PL (2003) The airline passenger: current medical issues. Travel Med Infect Dis 1:94–102.

    Google Scholar 

  • Odoul M, Fouillet B, Nouri B, Chambon R, Chambon P (1994) Specific determination of cyanide in blood by headspace gas chromatography. J Anal Toxicol 18:205–207.

    Google Scholar 

  • Pakhomova AA, Mukhamedieva LN, Mikos KN (2006) [Air quality monitoring on the International Space Station]. Aviakosm Ekolog Med 40:46–49.

    Google Scholar 

  • Patterson RE, Rayman RB (1996) Aerospace air pollution issues. Otolaryngol Head Neck Surg 114:277–280.

    Google Scholar 

  • Pearson DW, Clark G, Moore CM (1969) A comparison of the behavioral effects of various levels of chronic disulfoton poisoning, Report No. FAA-AM-69-19 (1969 Oct). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Rayman (2001) Aircraft cabin air quality and bills in Congress [editorial: executive director’s column]. Aviat Space Environ Med 72:1055.

    Google Scholar 

  • Rayman (2002) National Academy of Sciences report on cabin air quality [editorial: executive director’s column]. Aviat Space Environ Med 73:319.

    Google Scholar 

  • Rayman RB (1997) Passenger safety, health, and comfort: a review. Aviat Space Environ Med 68:432–440.

    Google Scholar 

  • Rayman RB (2001) Aircraft cabin air quality: an overview [correction of overview]. Uchu Koku Kankyo Igaku 38:9–15.

    Google Scholar 

  • Rayman RB (2002) Cabin air quality: an overview. Aviat Space Environ Med 73:211–215.

    Google Scholar 

  • Rayman RB, McNaughton GB (1983) Smoke/fumes in the cockpit. Aviat Space Environ Med 54:738–740.

    Google Scholar 

  • Reins DA, Holmes DD, Hinshaw LB (1963) Acute and chronic effects of the insecticide endrin on renal function and renal hemodynamics, Report No. FAA-AM-63-26 (1963 Oct). U.S. Department of Transportation, Federal Aviation Agency, Civil Aeromedical Research Institute, Oklahoma City, OK.

    Google Scholar 

  • Repace J (2004) Flying the smoky skies: secondhand smoke exposure of flight attendants. Tob Control 13 Suppl 1:i8–19.

    Google Scholar 

  • Revzin AM (1970) Some acute and chronic effects of endrin on the brain, Report No. FAA-AM-70-11 (1970 Jul). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Revzin AM (1973a) Subtle changes in brain functions produced by single doses of mevinphos (phosdrin), Report No. FAA-AM-73-3 (1973 Feb). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Revzin AM (1973b) Transient blindness due to the combined effects of mevinphos and atropine, Report No. FAA-AM-73-4 (1973 Feb). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Rieders F (1975a) Cyanide: type A procedure. In: Sunshine I (ed) Methodology for Analytical Toxicology, Vol I (5th Printing, 1987). CRC Press, Inc., Boca Raton, FL pp 113–114.

    Google Scholar 

  • Rieders F (1975b) Cyanide: type B procedure. In: Sunshine I (ed) Methodology for Analytical Toxicology, Vol I (5th Printing, 1987). CRC Press, Inc., Boca Raton, FL pp 114–115.

    Google Scholar 

  • Rodkey FL, Hill TA, Pitts LL, Robertson RF (1979) Spectrophotometric measurement of carboxyhemoglobin and methemoglobin in blood. Clin Chem 25:1388–1393.

    Google Scholar 

  • Ryan LC, Endecott BR, Hanneman GD, Smith DR (1970) Effects of an organophosphorus pesticide on reproduction in the rat, Report No. FAA-AM-70-3 (1970 Jan). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Sanders DC (2007) Combustion toxicology research in the Biochemistry Research Unit, CAMI, 1970–1992. In: Collins WE, Wayda ME (eds) Index of FAA Office of Aerospace Medicine Reports: 1961 Through 2006 (DOT/FAA/AM-07/1); 2007 Jan. U.S. Department of Transportation, Federal Aviation Administration, Office of Aerospace Medicine, Washington, DC pp iv–xiv.

    Google Scholar 

  • Sanders DC, Chaturvedi AK (1994) An overview of aircraft fires, smoke toxicity, and survival – part I. In: Federal Air Surgeon’s Medical Bulletin. U.S. Department of Transportation, Federal Aviation Administration, Civil Aeromedical Institute, Oklahoma City, OK p 1 & 6.

    Google Scholar 

  • Sanders DC, Chaturvedi AK, Hordinsky JR (1999) Melatonin: aeromedical, toxicopharmacological, and analytical aspects. J Anal Toxicol 23:159–167.

    Google Scholar 

  • Sanders DC, Endecott BR, Chaturvedi AK (1991) Inhalation toxicology: XII. comparison of toxicity rankings of six polymers by lethality and by incapacitation in rats, Report No. DOT/FAA/AM-91/17 (1991 Dec). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Sanders DC, Endecott BR, Chaturvedi AK (1992) Comparison of toxicity rankings of six aircraft cabin polymers by lethality and by incapacitation in rats. Aviat Space Environ Med 63:870–874.

    Google Scholar 

  • Sanderson JH, Sotheran MF, Stattersfield JP (1978) A new method of carboxyhaemoglobin determination. Br J Ind Med 35:67–72.

    Google Scholar 

  • Smith PW (1962) Toxic hazards in aerial application, Report No. FAA-AM-62-8 (1962 Apr). U.S. Department of Transportation, Federal Aviation Agency, Civil Aeromedical Research Institute, Oklahoma City, OK.

    Google Scholar 

  • Smith PW, Robinson CP, Zelenski JD, Endecott BR (1977) The role of monamine oxidase inhibition in the acute toxicity of chlordimeform, Report No. FAA-AM-77-19 (1977 Aug). U.S. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, Washington, DC.

    Google Scholar 

  • Smith PW, Stavinoha WB, Ryan LC (1968) Cholinesterase inhibition in relation to fitness to fly. Aerosp Med 39:754–758.

    Google Scholar 

  • Smyth KC, Norton TS, Miller JH, Smooke MD (1992) Comparison of experimental and computed species concentration and temperature profiles in laminar, two-dimensional CH4/air diffusion flames. In: Smith SB (ed) Abstracts: Annual Conference on Fire Research (NISTIR 4924), October 13–15, 1992. U.S. Department of Commerce, Technology Administration, National Institute of Standards and Technology, Building and Fire Research Laboratory, Rockville, MD pp 57–58.

    Google Scholar 

  • Solomon KR, Thompson DG (2003) Ecological risk assessment for aquatic organisms from over-water uses of glyphosate. J Toxicol Environ Health B Crit Rev 6:289–324.

    Google Scholar 

  • Strahle WC (1993) An Introduction to Combustion. Gordon and Breach Publishers, Amsterdam, Netherlands pp 41–52.

    Google Scholar 

  • Strom-Tejsen P, Weschler CJ, Wargocki P, Myśków D, Zarzycka J (2008) The influence of ozone on self-evaluation of symptoms in a simulated aircraft cabin. J Expo Sci Environ Epidemiol 18:272–281.

    Google Scholar 

  • Strom-Tejsen P, Wyon DP, Lagercrantz L, Fang L (2007) Passenger evaluation of the optimum balance between fresh air supply and humidity from 7-h exposures in a simulated aircraft cabin. Indoor Air 17:92–108.

    Google Scholar 

  • The Encyclopedia Americana (1989) Aviation - The Encyclopedia Americana International Edition. Grolier Incorporated, Danbury, CT p 859.

    Google Scholar 

  • Thibeault C (1997) Cabin air quality. Aerospace Medical Association. Aviat Space Environ Med 68:80–82.

    Google Scholar 

  • Thibeault C (2002) Airliner cabin air quality. Occup Med 17:279–292.

    Google Scholar 

  • Tietz NW, Fiereck EA (1973) The spectrophotometric measurement of carboxyhemoglobin. Ann Clin Lab Sci 3:36–42.

    Google Scholar 

  • Tracqui A, Raul JS, Géraut A, Berthelon L, Ludes B (2002) Determination of blood cyanide by HPLC-MS. J Anal Toxicol 26:144–148.

    Google Scholar 

  • U.S. National Aeronautics and Space Administration (1967) Apollo 1: the fire 27 January 1967. Retrieved 14 February 2008 from http://www.history.nasa.gov/SP-4029/Apollo_01a_Summary.htm.

  • U.S. National Toxicology Program (1999) NTP toxicology and carcinogenesis studies of ethylbenzene (CAS No. 100-41-4) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser 466:1–231.

    Google Scholar 

  • Uges DRA (2004) Hospital toxicology. In: Moffat AC, Osselton MD, Widdop B, Galichet LY (eds) Clarke’s Analysis of Drugs and Poisons in Pharmaceuticals, Body Fluids and Postmortem Material, 3rd Ed. Pharmaceutical Press, London, UK pp 3–36.

    Google Scholar 

  • Uva Ade S (2002) [Aircraft cabin air quality: exposure to ozone]. Acta Med Port 15:143–151.

    Google Scholar 

  • van Netten C (1999) Multi-elemental analysis of jet engine lubricating oils and hydraulic fluids and their implication in aircraft air quality incidents. Sci Total Environ 229:125–129.

    Google Scholar 

  • van Netten C, Leung V (2000) Comparison of the constituents of two jet engine lubricating oils and their volatile pyrolytic degradation products. Appl Occup Environ Hyg 15:277–283.

    Google Scholar 

  • van Netten C, Leung V (2001) Hydraulic fluids and jet engine oil: pyrolysis and aircraft air quality. Arch Environ Health 56:181–186.

    Google Scholar 

  • Vieillefond H, Fourn P, Auffret R (1977) Characteristics in the atmosphere of long-range transport aircraft cabins. Aviat Space Environ Med 48:503–507.

    Google Scholar 

  • Welch B, Navias R (1997) Small fire extinguished on Mir. Retrieved 14 February 2008 from http://www.nasa.gov/centers/johnson/news/releases/1996_1998/97-30.html.

  • Wick RL, Jr., Irvine LA (1995) The microbiological composition of airliner cabin air. Aviat Space Environ Med 66:220–224.

    Google Scholar 

  • Widdop B (2002) Analysis of carbon monoxide. Ann Clin Biochem 39:378–391.

    Google Scholar 

  • Wieslander G, Lindgren T, Norback D, Venge P (2000) Changes in the ocular and nasal signs and symptoms of aircrews in relation to the ban on smoking on intercontinental flights. Scand J Work Environ Health 26:514–522.

    Google Scholar 

  • Williams LA (1970) Toxicology. In: Frankel S, Reitman S, Sonnenwirth AC (eds) Gradwohl’s Clinical Laboratory Methods and Diagnosis, 7th Ed. C.V. Mosby Company, St. Louis, MO pp 303–305.

    Google Scholar 

  • Williams LA (1975) Carbon Monoxide: type A procedure. In: Sunshine I (ed) Methodology for Analytical Toxicology. CRC Press, Inc., Boca Raton, FL pp 64–66.

    Google Scholar 

  • Williams LA, Linn RA, Zak B (1960) Ultraviolet absorptiometry of palladium for determination of carbon monoxide hemoglobin. Am J Clin Pathol 34:334–337.

    Google Scholar 

  • Winek CL, Prex DM (1981) A comparative study of analytical methods to determine postmortem changes in carbon monoxide concentration. Forensic Sci Int 18:181–187.

    Google Scholar 

  • Wood W, Gabica J, Brown HW, Watson M, Benson WW (1971) Implication of organophosphate pesticide poisoning in the plane crash of a duster pilot. Aerosp Med 42:1111–1113.

    Google Scholar 

  • Wyss R, Stossel U, Muff S (2001) [Air travel--a disease risk?]. Ther Umsch 58:399–403.

    Google Scholar 

  • Zamecnik J, Tam J (1987) Cyanide in blood by gas chromatography with NP detector and acetonitrile as internal standard. Application on air accident fire victims. J Anal Toxicol 11:47–48.

    Google Scholar 

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Acknowledgments

The author is grateful to Kristi J. Craft for assisting in the compilation of references and for providing critical remarks and suggestions in the organizational and grammatical structures of the manuscript.

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Correspondence to Arvind K. Chaturvedi .

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Chaturvedi, A.K. (2012). Aerospace Toxicology Overview: Aerial Application and Cabin Air Quality. In: Whitacre, D. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 214. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0668-6_2

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