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Tumour-Associated Macrophages pp 105–115Cite as

Vascular Endothelial Growth Factor and Tumour-Associated Macrophages

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Abstract

Various epidemiological, clinical, and experimental studies have not only demonstrated a link between chronic inflammation and cancer onset, but also shown that myeloid cells from the bone marrow such as tumor-infiltrating macrophages significantly influence tumor progression (de Visser et al., Nature Rev. Cancer 6:24–37, 2006). Tumor angiogenesis is a crucial step in tumor development as tumors have to establish a blood supply to grow and metastasize. Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis, the use of transgenic mouse models and analysis of human tumor biopsies have shown that the tumor microenvironment with infiltrating macrophages are important for regulating the process of tumor angiogenesis (Murdoch et al., Nat Rev. Cancer 8:618–631, 2008). The pro-angiogenic vascular endothelial growth factor (VEGF) is known to be the master regulator of angiogenesis due to its strong mitogenic effect on endothelial cells (Keck et al., Science 246:1309–1312, 1989; Leung et al. 1999), and macrophages are capable of releasing large amounts of VEGF (Dirkx et al., J. Leukoc. Biol. 80:1183–1196, 2006).

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Acknowledgements

Acknowledgements and Competing Interests statement: We acknowledge the support of the Deutsche Forschungs Gemeinschaft to C.S. (STO 787/1-1 and STO 787/1-2) and NIH CA82515 to R.S.J.

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Authors and Affiliations

  1. Molecular Biology Section, Division of Biology, University of California, San Diego, CA, 92093, USA

    Christian Stockmann & Randall S. Johnson

  2. Institut für Physiologie, University of Duisburg-Essen, Duisburg-Essen, Germany

    Christian Stockmann

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  1. Christian Stockmann
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  2. Randall S. Johnson
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Correspondence to Randall S. Johnson .

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  1. Inserm-CNRS-Universitie de Mediteranee, Inflammation Biology Group, Centre d'Immunologie Marseille Luminy, Parc Scientifique de Luminy, Case 906, Marseille, Cedex 9, France

    Toby Lawrence

  2. Barts & The London Queen Mary's, School of Medicine & Dentistry, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

    Thorsten Hagemann

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Stockmann, C., Johnson, R.S. (2011). Vascular Endothelial Growth Factor and Tumour-Associated Macrophages. In: Lawrence, T., Hagemann, T. (eds) Tumour-Associated Macrophages. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0662-4_8

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