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Tumour-Associated Macrophages pp 167–181Cite as

Role of Hypoxia-Inducible Transcription Factors in TAM Function

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Abstract

Tumour progression is characterized by massive cellular proliferation associated with alterations of the tumour microenvironment. Hence, the tumour microenvironment is considered to be of great importance for tumourigenesis and, as a consequence, might influence the response to antitumour therapy. The microenvironmental alterations comprise hypoxia, acidosis, nutrient starvation, as well as increased interstitial fluid pressure (Denko 2008; Milosevic et al. 2004; Pouyssegur et al. 2006; Vaupel et al. 1989) and are largely the result of a defective and/or inadequate tumour vasculature which develops during rapid tumour growth (Bertout et al. 2008; Brown and Giaccia 1998; Vaupel et al. 1989; Vaupel 2004). Hypoxia is present in virtually every solid tumour and probably represents the most persistent of the microenvironmental hallmarks that sway tumour progression.

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  1. Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie and Molekulares Krebsforschungszentrum, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany

    Nadine Rohwer & Thorsten Cramer

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  1. Nadine Rohwer
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  2. Thorsten Cramer
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  1. Inserm-CNRS-Universitie de Mediteranee, Inflammation Biology Group, Centre d'Immunologie Marseille Luminy, Parc Scientifique de Luminy, Case 906, Marseille, Cedex 9, France

    Toby Lawrence

  2. Barts & The London Queen Mary's, School of Medicine & Dentistry, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

    Thorsten Hagemann

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Rohwer, N., Cramer, T. (2011). Role of Hypoxia-Inducible Transcription Factors in TAM Function. In: Lawrence, T., Hagemann, T. (eds) Tumour-Associated Macrophages. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0662-4_12

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