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The Measles Virus NTAIL-XD Complex: An Illustrative Example of Fuzziness

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Fuzziness

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 725))

Abstract

In this chapter, I focus on the biochemical and structural characterization of the complex between the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (NTAIL) and the C-terminal X domain (XD) of the viral phosphoprotein (P). I summarize the main experimental data available so far pointing out the prevalently disordered nature of NTAIL even after complex formation and the role of the flexible C-terminal appendage in the binding reaction. I finally discuss the possible functional role of these residual disordered regions within the complex in terms of their ability to capture other regulatory, binding partners.

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Authors and Affiliations

  1. Architecture et Fonction des Macromolécules Biologiques, Universités d’Aix-Marseille I et II, Marseille, France

    Sonia Longhi

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  1. Sonia Longhi
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Editors and Affiliations

  1. Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary

    Monika Fuxreiter PhD

  2. Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary

    Peter Tompa PhD

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Longhi, S. (2012). The Measles Virus NTAIL-XD Complex: An Illustrative Example of Fuzziness. In: Fuxreiter, M., Tompa, P. (eds) Fuzziness. Advances in Experimental Medicine and Biology, vol 725. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0659-4_8

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