Fuzziness pp 15-26 | Cite as

Dynamic Fuzziness During Linker Histone Action

  • Steven J. McBryant
  • Jeffrey C. HansenEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 725)


Linker histones are multi-domain nucleosome binding proteins that stabilize higher order chromatin structures and engage in specific protein-protein interactions. Here we emphasize the structural and functional properties of the linker histone C-terminal domain (CTD), focusing on its intrinsic disorder, interaction-induced secondary structure formation and dynamic fuzziness. We argue that the fuzziness inherent in the CTD is a primary molecular mechanism underlying linker histone function in the nucleus.


Chromatin Structure Linker Histone High Order Chromatin Structure Secondary Structure Formation Dynamic Fuzziness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyColorado State UniversityColoradoUSA

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