Juvenile Neuronal Ceroid Lipofuscinoses

  • Shiyao Wang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 724)


Juvenile neuronal ceroid lipofuscinoses (JNCL) is the most common type of the neuronal ceroid lipofuscinoses (NCLs), a group of pediatric neurodegenerative diseases. In this chapter the genetic and biochemical basis, pathogenesis, clinical features, histopathological features, diagnosis and therapeutic strategies of the JNCL are reviewed. The premature death of the patients and subnormal life quality are inevitable due to the lack of understanding of pathogenesis and limitation in treatment. Hence we are still a long way to conquer the disease.


Neurodegenerative Disease Prenatal Care Enzyme Replacement Therapy Premature Death Stem Cell Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  • Shiyao Wang
    • 1
  1. 1.People’s HospitalPeking UniversityBeijingChina

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