Abstract
AMP-activated protein kinase (AMPK) is a heterotrimer, comprising a catalytic α subunit and regulatory β and γ subunits, that senses cellular energy levels. When energy supply is compromised, activated AMPK limits energy utilization and promotes energy production to ensue cell survival. Intriguingly, recent findings show that AMPK is important in functions that go beyond the maintenance of energy homeostasis. In this mini-review, the role of AMPK in controlling retinal pigment epithelium cell phagocytosis, permeability, immune response, and survival under oxidative stress is discussed.
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Qin, S. (2012). Roles for AMP-Activated Protein Kinase in RPE Cell Function. In: LaVail, M., Ash, J., Anderson, R., Hollyfield, J., Grimm, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 723. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0631-0_95
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DOI: https://doi.org/10.1007/978-1-4614-0631-0_95
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