Roles for AMP-Activated Protein Kinase in RPE Cell Function

  • Suofu QinEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)


AMP-activated protein kinase (AMPK) is a heterotrimer, comprising a catalytic α subunit and regulatory β and γ subunits, that senses cellular energy levels. When energy supply is compromised, activated AMPK limits energy utilization and promotes energy production to ensue cell survival. Intriguingly, recent findings show that AMPK is important in functions that go beyond the maintenance of energy homeostasis. In this mini-review, the role of AMPK in controlling retinal pigment epithelium cell phagocytosis, permeability, immune response, and survival under oxidative stress is discussed.


AMPK Barrier function Inflammation Phagocytosis RPE Survival 


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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Biological SciencesRetinal Disease Research, Allergan, Inc.IrvineUSA

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