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On Your Marks… Get Bound… Internalize!

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Book cover Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 723))

Abstract

Photoreceptor shedding and its phagocytosis by the retinal pigment epithelium is a crucial process in the renewal of the light-sensitive photoreceptor outer segments (POS). This internalization process shares many components used by macrophages in apoptotic cell clearance, but is unique in that this process is rhythmic. This chapter discusses the molecular mechanisms known so far to be involved in the journey of the POS that follows three sequential steps: particle recognition, binding, and internalization.

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Author information

Authors and Affiliations

  1. INSERM, U968, Paris, 75012, France

    Ah-Lai Law & Emeline F. Nandrot

  2. Genetics Department, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris, 75012, France

    Ah-Lai Law & Emeline F. Nandrot

  3. CNRS, UMR_7210, 17 rue Moreau, Paris, 75012, France

    Ah-Lai Law & Emeline F. Nandrot

Authors
  1. Ah-Lai Law
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  2. Emeline F. Nandrot
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Corresponding author

Correspondence to Emeline F. Nandrot .

Editor information

Editors and Affiliations

  1. University of California, San Francisco, n/a, San Francisco, 94143, USA

    Matthew M. LaVail

  2. University of Oklahoma Health Sciences C, Oklahoma City, 73104, USA

    John D. Ash

  3. Health Science Center, Dean A. McGee Eye Inst., University of Oklahoma, Stanton L. Young Blvd. 608, OKLAHOMA CITY, 73104, Oklahoma, USA

    Robert E. Anderson

  4. Division of Ophthalmology, Cole Eye Institute at the Cleveland Clin, Euclid Ave. 9500, Cleveland, 44195, Ohio, USA

    Joe G. Hollyfield

  5. Experimental Ophthalmology, University of Zurich, ZURICH, 8091, Switzerland

    Christian Grimm

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© 2012 Springer Science+Business Media, LLC

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Law, AL., Nandrot, E.F. (2012). On Your Marks… Get Bound… Internalize!. In: LaVail, M., Ash, J., Anderson, R., Hollyfield, J., Grimm, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 723. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0631-0_91

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