On Your Marks… Get Bound… Internalize!

  • Ah-Lai Law
  • Emeline F. NandrotEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)


Photoreceptor shedding and its phagocytosis by the retinal pigment epithelium is a crucial process in the renewal of the light-sensitive photoreceptor outer segments (POS). This internalization process shares many components used by macrophages in apoptotic cell clearance, but is unique in that this process is rhythmic. This chapter discusses the molecular mechanisms known so far to be involved in the journey of the POS that follows three sequential steps: particle recognition, binding, and internalization.


Retinal pigment epithelium Photoreceptor outer segments Phagocytosis Daily rhythm αvβ5 integrin MFG-E8 FAK MerTK Annexin 2 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.INSERM, U968ParisFrance
  2. 2.Genetics DepartmentUPMC Univ Paris 06, UMR_S 968, Institut de la VisionParisFrance
  3. 3.CNRS, UMR_7210ParisFrance

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