ERG Critical Flicker Frequency Assessment in Humans

  • Kristen E. Bowles
  • Timothy W. KraftEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)


Scotopic and photopic critical flicker frequency (CFF) were measured in normal subjects between the ages 20–28 and 50–58 years. Flicker electroretinograms (ERG) were recorded with stimulus frequencies from 4 to 16 Hz for scotopic intensities and 25–72 Hz for photopic intensities. ERG responses were quantified by the fast Fourier transform (FFT) magnitude. CFF was determined by fitting a line to the log-FFT-response peak vs. frequency. The slope of the older group was very similar to that of the younger group. The younger group displayed a consistent trend of higher CFF at all intensities tested.


Critical flicker frequency Aging Electroretinogram Flicker Scotopic Photopic 


  1. Aguilar M, Stiles WS (1954) Saturation of the rod mechanism of the retina at high levels of stimulation. Optica Acta 1:59–65CrossRefGoogle Scholar
  2. Birch DG, Anderson JL (1992) Standardized full-field electroretinogram. Normal values and their variation with age. Arch Ophthalmol 110:1571–1576PubMedCrossRefGoogle Scholar
  3. Conner JD, MacLeod DI (1977) Rod photoreceptors detect rapid flicker. Science 195:698–699PubMedCrossRefGoogle Scholar
  4. Coppinger NW (1955) The relationship between critical flicker frequency and chronological age for varying levels of stimulus brightness. J Geront 10:48–52PubMedGoogle Scholar
  5. Curcio CA, Millican CL, Allen KA et al (1993) Aging of the human photoreceptor mosaic: Evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci 34:3278–3296PubMedGoogle Scholar
  6. Gao H, Hollyfield JG (1992) Aging of the human retina. Differential loss of neurons and retinal pigment epithelium cells. Invest Ophthalmol Vis Sci 33:1–17Google Scholar
  7. Hecht S, Smith EL (1936) Intermittent stimulation by light. VI. Area and the relation between critical frequency and intensity. J Gen Physiol 19: 979–991PubMedCrossRefGoogle Scholar
  8. Loranger AW (1959) Critical flicker frequency and some intellectual functions in old age. J Geront 14:323–327PubMedGoogle Scholar
  9. Marmor MF, Holder GE, Seeliger MW et al(2004) Standard for clinical electroretinography (2004 update) Doc Ophthalmol 108:107–114PubMedCrossRefGoogle Scholar
  10. Misiak H (1947) Age and sex differences in critical flicker frequency. J Exp Physiol 37:318–322Google Scholar
  11. Odom JV, Reits D, Burger N, et al (1992) Flicker electroretinograms: A systems analytic approach. Optom Vis Sci 69:106–116PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Vision SciencesUniversity of Alabama at BirminghamBirminghamUSA

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