Correlation Between Spectral Domain OCT Retinal Nerve Fibre Layer Thickness and Multifocal Pattern Electroretinogram in Advanced Retinitis Pigmentosa

  • Ieva SliesoraityteEmail author
  • Eric Troeger
  • Antje Bernd
  • Anne Kurtenbach
  • Eberhart Zrenner
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)


Our aim is to assess the correlation between retinal nerve fibre layer thickness and ganglion cell function by electrophysiological means in advanced retinitis pigmentosa (RP) patients. A prospective observational case–control study enrolled 12 RP patients (age average 44 ± 14 years) with concentric visual field loss (≤10o) and 12 healthy age-matched control for testing. The peripapillary retinal nerve fibre layer (RNFL) thickness was assessed by spectral domain optical coherence tomography. The VERIS system was used to record multifocal pattern electroretinograms (mfPERG), a measure of inner retinal functional output. Amplitudes of P1N2 component were 42 ± 14, 53 ± 25 and 42 ± 17 nV within temporal superior, temporal, and temporal inferior region in RP, and 174 ± 52, 171 ± 46 and 144 ± 15 nV respectively in the control group (p < 0.01). RNFL thickness was 139 ± 46, 109 ± 34 and 153 ± 31 μm within temporal superior, temporal, and temporal inferior region in RP; and 131 ± 15, 79 ± 16 and 144 ± 15 μm respectively in the control group (p > 0.05). The diminution of photoreceptors sensory inputs in advanced RP patients corresponds with reduced amplitudes in mulitifocal pattern electroretinogram, although RNFL measurements indicate no detectable loss of RGC.


Retinitis pigmentosa Multifocal pattern electroretinography Retinal nerve fibre layer Ganglion cell Retinal cell survival 



We thank Pro-Retina (Achen, Germany) for providing financial support to IS.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Ieva Sliesoraityte
    • 1
    Email author
  • Eric Troeger
    • 1
  • Antje Bernd
    • 1
  • Anne Kurtenbach
    • 1
  • Eberhart Zrenner
    • 1
  1. 1.Centre for Ophthalmology, Institute for Ophthalmic ResearchUniversity of TuebingenTuebingenGermany

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