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Imaging the Photoreceptor Mosaic with Adaptive Optics: Beyond Counting Cones

  • Pooja Godara
  • Melissa Wagner-Schuman
  • Jungtae Rha
  • Thomas B. ConnorJr.
  • Kimberly E. Stepien
  • Joseph CarrollEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)

Abstract

Recent years have seen an explosion in the development of novel ophthalmic imaging devices, delivering noninvasive views of the living retina. Adaptive optics (AO) imaging systems enable resolution of individual cells in the living retina. Analysis of these images has been limited to measures of cone density and regularity. Here, we introduce a small case series where the information in the high-resolution image extends beyond these standard metrics. These images should serve as the basis for evolving discussion as to how best to interpret AO retinal images.

Keywords

Adaptive optics Cone degeneration Photoreceptor RPE Retinal imaging 

Notes

Acknowledgments

The authors thank B. Schroeder and P.M. Summerfelt for technical assistance. J. Carroll is the recipient of a Career Development Award from Research to Prevent Blindness. This study was supported by NIH grants P30EY001931 and R01EY017607, The Thomas M. Aaberg, Sr. Retina Research Fund, and an unrestricted grant from Research to Prevent Blindness. This investigation was conducted in a facility constructed with support from Research Facilities Improvement Program Grant Number C06 RR-RR016511 from the National Center for Research Resources, NIH. Additional support comes from the Clinical and Translational Science Institute and the Biotechnology Innovation Center, NIH CTSA Grant UL1 RR 031973.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Pooja Godara
    • 1
  • Melissa Wagner-Schuman
    • 1
    • 2
  • Jungtae Rha
    • 1
  • Thomas B. ConnorJr.
    • 1
  • Kimberly E. Stepien
    • 1
  • Joseph Carroll
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of OphthalmologyMedical College of WisconsinMilwaukeeUSA
  2. 2.Departments of Ophthalmology and BiophysicsMedical College of WisconsinMilwaukeeUSA
  3. 3.Departments of Ophthalmology and Biophysics, and Cell Biology, Neurobiology, and AnatomyMedical College of WisconsinMilwaukeeUSA

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