Imaging the Photoreceptor Mosaic with Adaptive Optics: Beyond Counting Cones
Recent years have seen an explosion in the development of novel ophthalmic imaging devices, delivering noninvasive views of the living retina. Adaptive optics (AO) imaging systems enable resolution of individual cells in the living retina. Analysis of these images has been limited to measures of cone density and regularity. Here, we introduce a small case series where the information in the high-resolution image extends beyond these standard metrics. These images should serve as the basis for evolving discussion as to how best to interpret AO retinal images.
KeywordsAdaptive optics Cone degeneration Photoreceptor RPE Retinal imaging
The authors thank B. Schroeder and P.M. Summerfelt for technical assistance. J. Carroll is the recipient of a Career Development Award from Research to Prevent Blindness. This study was supported by NIH grants P30EY001931 and R01EY017607, The Thomas M. Aaberg, Sr. Retina Research Fund, and an unrestricted grant from Research to Prevent Blindness. This investigation was conducted in a facility constructed with support from Research Facilities Improvement Program Grant Number C06 RR-RR016511 from the National Center for Research Resources, NIH. Additional support comes from the Clinical and Translational Science Institute and the Biotechnology Innovation Center, NIH CTSA Grant UL1 RR 031973.