Looking into Eyes: Rhodopsin Pathologies in Drosophila
The detailed examination of eye structure and function in numerous Drosophila mutants has provided unprecedented insights into retinal physiology and pathology. Many Drosophila mutants that undergo retinal degeneration (RD) exhibit structural and/or dynamic alterations of the photon receptor rhodopsin, and similar defects cause retinitis pigmentosa (RP) in humans. Here, we consider how the use of Drosophila has advanced our understanding of RP and highlight new mechanisms underlying rhodopsin-mediated pathologies in the retina.
KeywordsRetinitis pigmentosa Retinal degeneration Rhodopsin Drosophila Photoreceptor Retina Phototransduction Autophagy ER stress
Work in the Ueffing laboratory is supported by the EU Grant NEUROTRAIN (MEST-CT-2005-020235), RETNET (MRTN-CT-2003-504003) and EVI-GENORET (LSHG-CT-2005-512036 to MU).
- Griciuc A, Aron L, Roux MJ et al (2010b) Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila. PLoS Genet 6Google Scholar