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Zebrafish: A Model System for the Investigation of Novel Treatments for Retinal Disease

  • Cheryl Y. Gregory-EvansEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)

Abstract

Over the latter part of the twentieth century the zebrafish, Danio rerio, has emerged as a preeminent model system for studying developmental biology, physiology, toxicology, and disease. The key driver has been the genetic tractability of the zebrafish, enabling numerous mutant strains to become available for analysis. The large eyes and the optical transparency of zebrafish embryo make it especially suited for investigating diseases of the retina. Moreover, visual development is rapid and closely resembles that of human retina including an elaborate color visual system. With the ability to carry out high-throughput screens in vivo, this vertebrate model will likely emerge as a leader for the identification of novel drugs for the treatment of retinal disease.

Keywords

Zebrafish Retinal disease Treatment Chemical mutagenesis Morpholino Transgenic Embryogenesis Eye development Small molecule screen 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of OphthalmologyUniversity of British ColumbiaVancouverCanada

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