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Translational Vision Research Models Program

  • Jungyeon Won
  • Lan Ying Shi
  • Wanda Hicks
  • Jieping Wang
  • Juergen K. Naggert
  • Patsy M. NishinaEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)

Abstract

The TVRM program at The Jackson Laboratory (JAX) is tailored to provide genetically defined models of vision-associated diseases to the Research Community. It utilizes chemical mutagenesis to generate mutations, and indirect ophthalmoscopy, slit lamp biomicroscopy, fundus photography and electroretinography (ERG) to screen for disease phenotypes. To date 60 ocular models have been identified (Won et al. 2010). Three new mutant alleles that lead to retinal degeneration are described herein.

Keywords

Retinal degeneration Mouse ENU mutagenesis Translational vision research models Pde6a Tulp1 Rhodopsin 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Jungyeon Won
    • 1
  • Lan Ying Shi
    • 1
  • Wanda Hicks
    • 1
  • Jieping Wang
    • 1
  • Juergen K. Naggert
    • 1
  • Patsy M. Nishina
    • 1
    Email author
  1. 1.The Jackson LaboratoryBar HarborUSA

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