Advertisement

An Application for Mammalian Optic Nerve Repair by Fish Regeneration-Associated Genes

  • Yoshiki Koriyama
  • Kayo Sugitani
  • Toru Matsukawa
  • Satoru KatoEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)

Abstract

Nerve injury leads to retrograde neuronal degeneration and cell death in adult mammalian CNS neurons. The retinal ganglion cells (RGCs) of rat fail to regenerate and become apoptotic after optic nerve injury. In contrast, goldfish RGCs can survive and regrow their axons and recover their visual function after injury. One of the explanations for these different regenerative properties in both animals is that some regeneration-associated molecules can be induced in the fish visual system, but not in rat. Such regeneration-associated molecules derived from fish might exert cell survival and nerve regeneration in mammals. In this viewpoint, we sought candidate molecules from axotomized fish retinas by differential screening. In this paper, we summarize the optic nerve regeneration factors from goldfish retina which promote cell survival and/or neurite outgrowth. Finally, we used these molecules in an attempt to rescue mammalian RGCs and regenerate their optic nerve. Such regeneration-associated molecules derived from fish retina successfully induced optic nerve regeneration in rat. These molecules could potentially offer new avenues for developing treatments for human retinal degenerative disorders such as glaucoma.

Keywords

Optic nerve Regeneration Survival Retinal ganglion cell Repair Apoptosis 

References

  1. Filiano AJ, Bailey CD, Tucholski J et al (2008) Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling. FASEB J 22:2662–2675PubMedCrossRefGoogle Scholar
  2. Harvey AR, Hellström M, Rodger J (2009) Gene therapy and transplantation in the retinofugal pathway. Prog Brain Res 175:151–161PubMedCrossRefGoogle Scholar
  3. Kato S, Devadas M, Okada K et al (1999) Fast and slow recovery phases of goldfish behavior after transection of the optic nerve revealed by a computer image processing system. Neuroscience 93:907–914PubMedCrossRefGoogle Scholar
  4. Kato S, Koriyama Y, Matsukawa T et al (2007) Optic nerve regeneration in goldfish. In: Becker CG, Becker T (eds) Model Organisms in Spinal Cord Regeneration, Wiley-VCH, WeinheimGoogle Scholar
  5. Koriyama Y, Homma K, Sugitani K et al (2007) Upregulation of IGF-I in the goldfish retinal ganglion cells during the early stage of optic nerve regeneration. Neurochem Int 50:749–756PubMedCrossRefGoogle Scholar
  6. Koriyama Y, Yasuda R, Homma K et al (2009) nNOS, Nitric oxide-cGMP signaling regulates axonal elongation during optic nerve regeneration in the goldfish in vitro and in vivo. J Neurochem 110:890–901PubMedCrossRefGoogle Scholar
  7. Koriyama Y, Chiba K, Yamazaki M et al (2010) Long-acting genipin derivative protects retinal ganglion cells from oxidative stress models in vitro and in vivo through the Nrf2/antioxidant response element signaling pathway. J Neurochem 115:79–91PubMedCrossRefGoogle Scholar
  8. Matsukawa T, Sugitani K, Mawatari K et al (2004) Role of purpurin as a retinol-binding protein in goldfish retina during the early stage of optic nerve regeneration: its priming action on neurite outgrowth. J Neurosci 24:8346–8353PubMedCrossRefGoogle Scholar
  9. Mey J, Thanos S (1993) Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res 602:304–317PubMedCrossRefGoogle Scholar
  10. Schubert D, LaCorbiere M (1985) Isolation of an adhesion-mediating protein from chick neural retina adherons. J Cell Biol 101:1071–1077PubMedCrossRefGoogle Scholar
  11. Stuermer CA, Bastmeyer M, Bähr M et al (1992) Trying to understand axonal regeneration in the CNS of fish. J Neurobiol 23:537–550PubMedCrossRefGoogle Scholar
  12. Sugitani K, Matsukawa T, Koriyama Y et al (2006) Upregulation of retinal transglutaminase ­during the axonal elongation stage of goldfish optic nerve regeneration. Neuroscience 142:1081–1092PubMedCrossRefGoogle Scholar
  13. Turner JE, Delaney RK, Johnson JE (1980) Retinal ganglion cell response to nerve growth factor in the regenerating and intact visual system of the goldfish (Carassius auratus). Brain Res 197:319–330PubMedCrossRefGoogle Scholar
  14. Villegas-Pérez MP, Vidal-Sanz M, Rasminsky M (1993) Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats. J Neurobiol 24: 23–36PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Yoshiki Koriyama
    • 1
  • Kayo Sugitani
    • 2
  • Toru Matsukawa
    • 1
  • Satoru Kato
    • 1
    Email author
  1. 1.Department of Molecular NeurobiologyKanazawa UniversityKanazawaJapan
  2. 2.Division of Health SciencesKanazawa UniversityKanazawaJapan

Personalised recommendations