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Autoimmune Biomarkers in Age-Related Macular Degeneration: A Possible Role Player in Disease Development and Progression

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Book cover Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 723))

Abstract

Age-related macular degeneration (AMD) is the leading cause of legal blindness among people over the age of 50. In recent years, a role for inflammation in the pathogenesis of both AMD in general and drusen in particular has been established at the biological, experimental, and genetic level. The purpose of this chapter is to (1) illustrate our rationale for the hypothesis that, in the aforementioned inflammatory context, auto-antibodies (auto-Abs) are biomarkers relevant to ocular disease status in AMD, based on a brief review of the literature; (2) present our preliminary data supporting this hypothesis from our ongoing investigations; and (3) propose a mechanistic framework for the formation of auto-Abs in AMD and their possible role in disease development and progression. Auto-Ab targets have the potential to be important disease biomarkers and may contribute significantly to AMD development and progression.

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Acknowledgments

Supported by the International Retinal Research Foundation, NIH grants K23 EY000409 and R21 EY018416, and an unrestricted grant from Research to Prevent Blindness.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

    Alessandro Iannaccone, Indira Neeli & Pratheebha Krishnamurthy

  2. Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

    Indira Neeli & Marko Z. Radic

  3. Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

    Nataliya I. Lenchik & Ivan C. Gerling

  4. Department of Neurology, Stout Mass Spectrometry Laboratory, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

    Haibao Wan & Dominic M. Desiderio

Authors
  1. Alessandro Iannaccone
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  2. Indira Neeli
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  3. Pratheebha Krishnamurthy
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  4. Nataliya I. Lenchik
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  5. Haibao Wan
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  6. Ivan C. Gerling
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  7. Dominic M. Desiderio
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  8. Marko Z. Radic
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Corresponding author

Correspondence to Alessandro Iannaccone .

Editor information

Editors and Affiliations

  1. University of California, San Francisco, n/a, San Francisco, 94143, USA

    Matthew M. LaVail

  2. University of Oklahoma Health Sciences C, Oklahoma City, 73104, USA

    John D. Ash

  3. Health Science Center, Dean A. McGee Eye Inst., University of Oklahoma, Stanton L. Young Blvd. 608, OKLAHOMA CITY, 73104, Oklahoma, USA

    Robert E. Anderson

  4. Division of Ophthalmology, Cole Eye Institute at the Cleveland Clin, Euclid Ave. 9500, Cleveland, 44195, Ohio, USA

    Joe G. Hollyfield

  5. Experimental Ophthalmology, University of Zurich, ZURICH, 8091, Switzerland

    Christian Grimm

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Iannaccone, A. et al. (2012). Autoimmune Biomarkers in Age-Related Macular Degeneration: A Possible Role Player in Disease Development and Progression. In: LaVail, M., Ash, J., Anderson, R., Hollyfield, J., Grimm, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 723. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0631-0_2

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