The moderate rate of retinal degeneration in the rd10(PDE6βrd10) mouse makes it a valuable model for therapeutic studies in autosomal recessive retinitis pigmentosa. The peak period of photoreceptor apoptosis occurs between P18 and P25; however, this degeneration can be delayed if the animal is dark-reared from birth. In this study, we find that dark-rearing (DR) slows the course of degeneration more significantly than previously reported, with a long-term preservation of both retinal structure and function in the first 3 months of life. Further investigation of this protective effect may offer insights into disease management in patients.
Dark-rearing Phosphodiesterase 6b rd10 Mouse model Rod ON-bipolar cells Electroretinogram
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We thank Wei Zhang for technical assistance. This study was supported by FFB Center Grant #C-GT-0607-0390-UPA02 and Hope for Vision.
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