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Dark-Rearing the rd10 Mouse: Implications for Therapy

  • Therese CroninEmail author
  • Arkady Lyubarsky
  • Jean Bennett
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)

Abstract

The moderate rate of retinal degeneration in the rd10(PDE6β rd10 ) mouse makes it a valuable model for therapeutic studies in autosomal recessive retinitis pigmentosa. The peak period of photoreceptor apoptosis occurs between P18 and P25; however, this degeneration can be delayed if the animal is dark-reared from birth. In this study, we find that dark-rearing (DR) slows the course of degeneration more significantly than previously reported, with a long-term preservation of both retinal structure and function in the first 3 months of life. Further investigation of this protective effect may offer insights into disease management in patients.

Keywords

Dark-rearing Phosphodiesterase 6b rd10 Mouse model Rod ON-bipolar cells Electroretinogram 

Notes

Acknowledgments

We thank Wei Zhang for technical assistance. This study was supported by FFB Center Grant #C-GT-0607-0390-UPA02 and Hope for Vision.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Therese Cronin
    • 1
    Email author
  • Arkady Lyubarsky
    • 1
  • Jean Bennett
    • 1
  1. 1.F.M. Kirby Center for Molecular OphthalmologyUniversity of PennsylvaniaPhiladelphiaUSA

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