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HCN1 Channels Significantly Shape Retinal Photoresponses

  • Naoyuki TanimotoEmail author
  • Arne Brombas
  • Frank Müller
  • Mathias W. Seeliger
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)

Abstract

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and are widely expressed in the central and peripheral nervous system and in cardiac tissues. All types of HCN channels are also expressed in the retina. Due to their rapid activation, HCN1 channels, which are expressed most abundantly in the inner segments of the photoreceptors, are particularly well suited to modulate retinal responses to flashed light or background light. In vivo functional analysis of HCN1 knockout mice using electroretinography has shown that HCN1 channels shorten retinal light responses under scotopic conditions and thus play an important role for the responsiveness to high-frequency repetitive stimuli. This chapter summarizes the functional phenotype of HCN1 knockout mice.

Keywords

Photoreceptors HCN1 channels Electroretinography Knockout mice Retinal signal processing Flicker ERG 

Notes

Acknowledgments

We thank Dr. Eric Kandel (Columbia University, USA) for providing the HCN1 knockout line. This work was supported by the Deutsche Forschungsgemeinschaft (DFG, grants Se837/5-2, and 6-1) to M.W.S., the Kerstan Foundation to N.T., and the European Union (grant LSHG-CT-2005-512036) to A.B. and F.M.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Naoyuki Tanimoto
    • 1
    Email author
  • Arne Brombas
    • 2
  • Frank Müller
    • 2
  • Mathias W. Seeliger
    • 1
  1. 1.Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic ResearchUniversity of TübingenTübingenGermany
  2. 2.Institut für Strukturbiologie und Biophysik (ISB-1)Forschungszentrum JülichJülichGermany

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