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Insulin-like Growth Factors and Cancer pp 179–191Cite as

Mouse Models of IGF-1R and Cancer

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

A variety of systems have been used to evaluate the role of the insulin-like growth factor (IGF) axis in cancer, including human tissue and serum, cell lines derived from spontaneous tumors from humans and other species, and genetically modified animals. As animal models of the IGF ligands (IGF-I, IGF-II) and IGF-binding proteins have been described elsewhere in this book, this chapter focuses on animal models of altered Igf1r gene expression.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada

    Craig I. Campbell, James J. Petrik & Roger A. Moorehead

Authors
  1. Craig I. Campbell
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  2. James J. Petrik
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  3. Roger A. Moorehead
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Corresponding author

Correspondence to Roger A. Moorehead .

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Editors and Affiliations

  1. , Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, NEW YORK, 10029, USA

    Derek LeRoith

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Campbell, C.I., Petrik, J.J., Moorehead, R.A. (2012). Mouse Models of IGF-1R and Cancer. In: LeRoith, D. (eds) Insulin-like Growth Factors and Cancer. Cancer Drug Discovery and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0598-6_9

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  • DOI: https://doi.org/10.1007/978-1-4614-0598-6_9

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