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Aqueous Suspensions

Chapter
Part of the Advances in Delivery Science and Technology book series (ADST)

Abstract

A good formulation of coarse particles dispersed in a liquid vehicle is facilitated by an understanding of the theory of particle technology and methodologies to assess physical properties of the resulting product. Formulation parameters include particle–vehicle interactions, sedimentation/flocculation kinetics, particle size and crystal form identity and stability, and appropriate suspension rheology to aid flocculation and minimize caking. The vehicle and stabilizers added must allow for creation of a flocculated system, prevent caking, and promote rapid redispersion. Additional delivery considerations include irritation and pain potential, in vitro vs. in vivo release methodologies, and the targeted delivery profile.

Keywords

Interfacial Tension Sustained Release Polymeric Micelle Sedimentation Volume Cortisone Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Controlled Release Society 2012

Authors and Affiliations

  1. 1.Pharmaceutical Sciences Veterinary Medicine R&D, Pfizer Inc.KalamazooUSA

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