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The Multiple Properties and Functions of Nucleolin

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The Nucleolus

Part of the book series: Protein Reviews ((PRON,volume 15))

Abstract

Nucleolin, one of the most abundant proteins of the nucleolus is a fascinating protein with multiple proposed functions within and outside the nucleoli. Since its discovery almost 40 years ago, it was proposed that nucleolin is involved in ribosome biogenesis but until recently the molecular mechanisms of this involvement were not known. Thanks to the development of new research strategies, it is now clear that nucleolin is an essential protein for RNA polymerase I transcription, ribosome assembly, cell cycle, and cell proliferation, but the mechanisms of these functions have just begun to be unraveled. In this review, we highlight the most recent data on nucleolin’s properties and functions in the nucleolus and nucleoplasm.

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Acknowledgments

The author’s work is supported by grants from Agence Nationale de la Recherche (ANR-07-BLAN-0062-01), Région Rhône-Alpes MIRA 2007 and 2010, Association pour la Recherche sur le Cancer n° ECL2010R01122, CEFIPRA n° 3803-1, and CNRS.

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  1. Ecole Normale Supérieure de Lyon, CNRS USR 3010, Laboratoire Joliot-Curie, Université de Lyon, Lyon, France

    Rong Cong & Sadhan Das

  2. The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China

    Rong Cong

  3. Ecole Normale Supérieure de Lyon, CNRS USR 3010, Laboratoire Joliot-Curie, Université de Lyon, 46 Allée d’Italie, 69007, Lyon, France

    Philippe Bouvet

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  1. Rong Cong
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  1. Dept. Biochemistry, University of Mississippi Medical Center, North State St. 2500, Jackson, 39216, Mississippi, USA

    Mark O. J. Olson

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Cong, R., Das, S., Bouvet, P. (2011). The Multiple Properties and Functions of Nucleolin. In: Olson, M. (eds) The Nucleolus. Protein Reviews, vol 15. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0514-6_9

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