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B Cell-Mediated Regulation of Immunity During Leishmania Infection

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Control of Innate and Adaptive Immune Responses during Infectious Diseases

Abstract

Intracellular pathogens cause a wide spectrum of clinical disease ranging from mild self-limiting infections to chronic diseases and even acute life-threatening illnesses. T cell-mediated immunity is central to effective immune control of Leishmania infection and the role that B cells and antibodies play in promoting immunopathology during disease associated with chronic Leishmania infection is becoming more clear. However, the role that B cells and antibodies play during a successful immune response may be subtle and range from protecting the host from a robust cell-mediated response to enhancing immune effectiveness. The B cell response may therefore be a significant component of both ineffective and effective immunity to Leishmania infection.

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Authors and Affiliations

  1. Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA, USA

    Katherine N. Gibson-Corley, Christine A. Petersen & Douglas E. Jones

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  1. Katherine N. Gibson-Corley
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  2. Christine A. Petersen
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  3. Douglas E. Jones
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Correspondence to Douglas E. Jones .

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  1. Medical Center, Div. Pulmonary Medicine, Cincinnati Children’s Hospital, Burnet Ave. 3333, Cincinnati, 45229-3039, Ohio, USA

    Julio Aliberti

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Gibson-Corley, K.N., Petersen, C.A., Jones, D.E. (2012). B Cell-Mediated Regulation of Immunity During Leishmania Infection. In: Aliberti, J. (eds) Control of Innate and Adaptive Immune Responses during Infectious Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0484-2_5

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