Particulating or mincing articular cartilage allows the chondrocytes to escape their lacunae and migrate. The freed chondrocytes are able to multiply and form new extracellular matrix. Over time, the new chondrocyte/matrix construct matures into hyaline-like cartilage. This technique has both autograft (Cartilage Autograft Implant System (CAIS™), DePuy Mitek, Raynham MA), and allograft (DeNovo® NT, Zimmer, Warsaw, IN) applications. Early positive animal outcomes have been followed by early positive clinical outcomes. The position for these techniques in the cartilage restoration/repair algorithm is under investigation, but initially it appears to be similar to current cell therapy techniques.
KeywordsParticulated cartilage Minced cartilage CAIS DeNovo NT
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